clpS:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
clpS |
|---|---|
| Gene Synonym(s) |
ECK0872, b0881, JW0865, yljA[1], yljA |
| Product Desc. |
specificity factor for ClpA-ClpP chaperone-protease complex[2][3] Substrate modulator for ClpAP; directs protease activity towards aggregated proteins[4] |
| Product Synonyms(s) |
regulatory protein for ClpA substrate specificity[1], ClpS[2][1], YljA[2][1], B0881[2][1] , ECK0872, JW0865, yljA, b0881 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): |
| Regulation/Activity | |
| Quick Links |
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Notes
ClpS is involved in degradation of N-end rule substrates by the ClpAP protease[5][6]
ClpS is needed for the degradation of N-end rule substrates by ClpAP. clpS is a non-essential gene. ClpS is homologous to eukaryotic E3 ubiquitin ligase n-recognin (Lupas, 2003).[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Erbse, A et al. (2006) ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature 439 753-6 PubMed
- ↑ Wang, KH et al. (2007) ClpS modulates but is not essential for bacterial N-end rule degradation. Genes Dev. 21 403-8 PubMed
