cheY:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
cheY |
|---|---|
| Gene Synonym(s) |
ECK1883, b1882, JW1871[1], JW1871 |
| Product Desc. |
chemotaxis regulator transmitting signal to flagellar motor component[1] Response regulator for chemotactic signal transduction; CheA is the cognate sensor protein[2] |
| Product Synonyms(s) | |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): tar-tap-cheRBYZ[3] |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
CheY is acetylated at lysine residues 92 and 109 by acetyl-CoA synthase (Acs). Proposed mechanism for optimum chemotaxis suggests alteration of side chain signaling state by rotation of Tyr106 side chain; this is presumably modulated by phosphorylation state of the molecule. A mutation resulting in a tyrosine to tryptophan substitution at position 106 results in a hyperactive phenotype, while a double mutation T87I/Y106W resulted in loss of activity. Substitutions at ILE95 affect FliM binding. Flagellar regulon.[2]
References
- ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 3.0 3.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
