bacA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
bacA |
|---|---|
| Gene Synonym(s) |
ECK3047, b3057, JW3029, uppP[1], uppP |
| Product Desc. |
undecaprenyl pyrophosphate phosphatase[2][3] Undecaprenyl pyrophosphate phosphatase BacA(UppP); overexpression confers bacitracin resistance[4] |
| Product Synonyms(s) |
undecaprenyl pyrophosphate phosphatase[1], B3057[2][1], BacA[2][1], UppP[2][1] , ECK3047, JW3029, uppP, b3057 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
BacA(UppP) encodes 75% of the cell's UppP activity. The bacA gene is not essential, but UppP activity is essential to synthesize undecaprenyl phosphate, a C55 lipid carrier for cell wall synthesis, so a ybjG pgpB bacA triple mutant is lethal; overexpression, but not wildtype levels, of the LpxT(YeiU) UppP activity rescues the triple mutant (El Ghachi, 2005). BacA does not encode undecaprenol phosphokinase activity as previously hypothesized. ybjG and bacA are not involved in lipid A modification (Touze, 2008).[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
