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References Suggestions


Standard Name


Gene Synonym(s)

ECK3249, b3262, JW5543, ccrM[1], ccrM

Product Desc.

predicted methyltransferase[2]; DNA adenine methyltransferase[3]

DNA adenine methyltransferase, SAM-dependent[4]

Product Synonyms(s)

predicted methyltransferase[1], B3262[2][1], YhdJ[2][1], CcrM[2][1] , ccrM, ECK3249, JW5543, b3262

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): yhdJ[2]

Quick Links

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In vitro DNA adenine methyltransferase activity has been demonstrated for YhdJ; overexpression of YhdJ leads to protection of chromosomal DNA from NsiI digestion, but DNA from wild type cells is not protected (Broadbent (2007). DNA from a DNA methyltransferase deficient strain (dam-, dcm-, EcoK-) does not react with anti-N6-methylA or anti-N4-methylC antibodies when YhdJ is expressed from the pBR322 Tet promoter; the yhdJ-containing pBR322 derivative was not resistant to a variety of restriction (personal communication: R. Vaisvila, S. Stickel and R.J. Roberts, unpublished results, April, 2006). The Kossykh (2004) report describing yhdJ as ccrM, an adenine methyltransferase, has been retracted.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.