From EcoliWiki
(Redirected from b3208)
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions


Standard Name


Gene Synonym(s)

ECK3197, b3208, JW3175, yrbM, mgt[1], mgt

Product Desc.

biosynthetic peptidoglycan transglycosylase[2][3]

Monofunctional peptidoglycan glycosyltransferase; monofunctional biosynthetic peptidoglycan transglycosylase; GTase; TGase[4]

Product Synonyms(s)

biosynthetic peptidoglycan transglycosylase[1], B3208[2][1], Mgt[2][1], YrbM[2][1], MtgA[2][1] , ECK3197, JW3175, mgt, yrbM, b3208

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): mtgA[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>


[back to top]

MtgA has flavomycin-resistant peptidoglycan synthesis activity (Di Berardino, 1996 [5]; Derouaux, 2007). mtgA is a non-essential gene (Schiffer, 1999). MtgA localizes to the division site and interacts with FtsW, FtsN, and FtsI in mcrA(Ts) mrcB- strains, indicating a role for MtgA in peptidoglycan synthesis related to the cell cycle (Derouaux, 2007). The use of the term transglycolase is ambiguous as it can describe both lytic and synthetic peptidoglycan activities, therefore glycosyltransferase is preferred (Di Berardino, 1996). MtgA lacks a penicillin binding domain and therefore is penicillin-insensitive. MtgA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor (Di Berardino, 1996). MtgA may be the glycan polymerase characterized by Hara (1984), although it has an apparent MW larger than MtgA (Di Berardino, 1996).[4]


[back to top]

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Di Berardino, M et al. (1996) The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesising enzymes. FEBS Lett. 392 184-8 PubMed