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References Suggestions


Standard Name


Gene Synonym(s)

ECK2681, b2687, JW2662, ygaG[1], ygaG

Product Desc.

autoinducer 2 (AI-2) synthase; acts in quorum sensing[2]; S-ribosylhomocysteine lyase (AI-2 synthesis protein)[3]

S-ribosylhomocysteine lyase, autoinducer 2 (AI-2) synthesis; functions in quorum sensing; acid-inducible[4]

Product Synonyms(s)

S-ribosylhomocysteinase[1], B2687[2][1], LuxS[2][1], YgaG[2][1] , ECK2681, JW2662, ygaG, b2687

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): luxS[2]

Quick Links

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E. coli luxS is capable of inducing V. harveyi luminescence. The products of LuxS are homocysteine and the AI-2 precursor 4,5-dihydroxy-2,3-pentadione (DPD). DPD is unstable and reacts with water to form AI-2, a hydroxymethylfuran. LuxS may be involved in the recycling of S-adenosylhomocysteine. LuxS also makes AI-3. LuxS is regulated by cyaR sRNA (De Lay, 2009).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.