alkB:Quickview

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Standard Name

alkB

Gene Synonym(s)

ECK2204, b2212, JW2200, aidD[1], aidD

Product Desc.

AlkB repair system for alkylated DNA and RNA[2][3]

Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase[4]; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA[5]

Product Synonyms(s)

oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions[1], B2212[2][1], AidD[2][1], AlkB[2][1] , aidD, ECK2204, JW2200, b2212

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ada-alkB[2], OP00100, alkB[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.[6]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. Falnes, PØ et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 178-82 PubMed
  5. Trewick, SC et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 174-8 PubMed
  6. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.