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References Suggestions


Standard Name


Gene Synonym(s)

ECK1959, b1961, JW1944, mec[1], mec

Product Desc.

DNA cytosine methylase[2][3]

DNA cytosine methyltransferase; internal cytosine methylated[4]

Product Synonyms(s)

DNA cytosine methylase[1], B1961[2][1], Mec[2][1], Dcm[2][1] , ECK1959, JW1944, mec, b1961

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): dcm-vsr[2]

Quick Links

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Method of Mutagenesis: Log-phase cultures of strain GM 1 were treated with Alkylating agent (N-methyl-N-nitro-nitrosoguanidine)[5]

Phenotype Observed: Mutants were tested for S-adenosylmethionine methyltransferase activity by measuring the levels of DNA-cytosine (S-adenosylmethionine and DNA-adenine. The mutants showed reduced or absent activity. Also, deficient in methylcytosine in DNA. [5]

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 Marinus, MG & Morris, NR (1973) Isolation of deoxyribonucleic acid methylase mutants of Escherichia coli K-12. J. Bacteriol. 114 1143-50 PubMed