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References Suggestions


Standard Name


Gene Synonym(s)

ECK0764, b0775, JW0758, G8004[1][2]

Product Desc.

biotin synthase[2][3];

Component of biotin synthase[2][3]

Biotin synthase; dethiobiotin to biotin pathway; iron-sulfur enzyme[4]

Product Synonyms(s)

biotin synthase[1], B0775[2][1], BioB[2][1] , ECK0764, JW0758, b0775

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): bioBFCD[2], OP00157

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Radical SAM superfamily. BioB contains two distinct Fe-S cluster binding sites, one site accommodates a [2Fe-2S](2+) cluster with partial noncysteinyl ligation, the other site accommodates a [4Fe-4S](2+,+) cluster that binds S-adenosylmethionine (SAM) at a unique Fe site of the [4Fe-4S](2+) cluster and undergoes O(2)-induced degradation via a distinct type of [2Fe-2S](2+) cluster intermediate.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.