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References Suggestions


Standard Name


Gene Synonym(s)

ECK0352, b0355, JW0346, yaiM[1], yaiM

Product Desc.

S-formylglutathione hydrolase[2][3]

S-formylglutathione hydrolase, formaldehyde degradation[4]

Product Synonyms(s)

predicted esterase[1], B0355[2][1], YaiM[2][1], FrmB[2][1] , ECK0352, JW0346, yaiM, b0355

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): frmB[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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FrmB also has p-nitrophenyl C2-C6 fatty acid ester and a-naphthyl acetate carboxylesterase activities in vitro. The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. FrmB is 50% identical to P. denitrificans S-formylglutathione hydrolase. FrmB and YeiG are 50% identical paralogs; double mutant is formaldehyde sensitive; this may explain why an frmB single mutant did not have a formadehyde phenotype when tested on Biolog plates (Herring, 2004). The amino terminal half of FrmB is homologus to the C-terminal half of YieL. S9 peptidase family; YeiG or FrmB are not in MEROPS yet, but it has homologs.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.