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References Suggestions


Standard Name


Gene Synonym(s)

ECK0253, b0251, JW0240[1], JW0240

Product Desc.

inner membrane lipoprotein YafY[2][3]

Inner membrane lipoprotein, function unknown; overproduction stimulates degP expression; CP4-6; putative prophage remnant[4]

Product Synonyms(s)

CP4-6 prophage; predicted DNA-binding transcriptional regulator[1], B0251[2][1], YafY[2][1] , ECK0253, JW0240, b0251

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): ykfI[2]

Quick Links

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yfjS and yafY are homologs. The first 17 aa of YafY are a type II signal peptide (Matsuyama, unpublished, cited in Miyadai, 2004). Although overproduction of YafY induces degP expression, YjfS does not; chimeric protein experiments demonstrate that the N- and C- termini of YafY have the degP stimulatory determinants (Miyadai, 2004). Originally, the annotation of yafY was fused to the upstream pseudogene ykfK. It is possible that a YkfK-YafW chimeric pseudogene product is made in vivo, but no function would be expected since cleavage of the type II signal is likely to be blocked in any chimeric protein synthesized. Expression of the native YafY lipoprotein gene in the chromosome has not yet been reported. E. coli B has a third protein in this family (UniProtKB:A2UFU7), 55% identical to YafY and YfjS, that demonstrates conservation of the shorter ORFs and their lipoprotein signals in this novel prophage gene family.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.