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References Suggestions


Standard Name


Gene Synonym(s)

ECK0030, b0029, JW0027, lytB, yaaE[1], yaaE

Product Desc.

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase[2][3]

Last, branched, step of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) synthesis from 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate; alternative nonmevalonate (DXP) pathway for terpenoid biosynthesis[4]

Product Synonyms(s)

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein[1], B0029[2][1], YaaE[2][1], LytB[2][1], IspH[2][1] , ECK0030, JW0027, lytB, yaaE, b0029

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): lsp-fkpB-ispH[2], ribF-ileS-lspA-fkpB-ispH[2], ileS-lsp, ileS-lspA-lytB, ribF-ileS-lspA-slpA-lytB

Quick Links

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The ispH gene is essential. IspH contains a [4Fe-4S] cluster. IspH affects penicillin tolerance and the stringent response.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.