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Browse and analyze data from Al Mamun et al. (Science 2012) Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks 338:1344-1348

This dataset of 93 genes was constructed by screening E. coli for mutants deficient in mutagenic repair of DNA breaks under stress, followed by secondary screens for genes that participate in activation of stress responses. This study identifies a network of genes involved in stress-induced mutagenesis (the SIM Network). This data browser allows you to examine the classification of SIM network genes and explore the data from different assays on individual network genes. You can also download excel versions of the supplemental tables from the paper.

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SIM Network Genes that confer a UVS Phenotype when Mutated

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Excel versions of supplemental tables:

ClassUV-sensitive SIM network genesConfirmed upstream of the SOS response
RegulatorshdfR
Electron transferhemL
Chaperones and proteaseshfq
Electron transferhscB
Chaperones and proteasesldcA
RegulatorslexA+
DNA replication and repair-relatedligA
Chaperones and proteaseslon
RegulatorsnusA
Electron transferpgi+
Metabolismpgl
Cellular processespstB
DNA replication and repairrecA+
DNA replication and repairrecB+
DNA replication and repairrecC+
DNA replication and repairrecF
RegulatorsrpoS
DNA replication and repairruvA
DNA replication and repairruvB
DNA replication and repairruvC
Electron transferubiA
DNA replication and repairumuC
RegulatorsuvrY+
UnknownyifE
UnknownyjcC
UnknownyqgE