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| Standard Name |
alkB |
|---|---|
| Gene Synonym(s) |
ECK2204, b2212, JW2200, aidD[1], aidD |
| Product Desc. |
AlkB repair system for alkylated DNA and RNA[2][3] Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase[4]; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA[5] |
| Product Synonyms(s) |
oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions[1], B2212[2][1], AidD[2][1], AlkB[2][1] , aidD, ECK2204, JW2200, b2212 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| public |
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Falnes, PØ et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 178-82 PubMed
- ↑ Trewick, SC et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 174-8 PubMed
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