PMID:16630628 - Revision history

imported>Wikientrybot: change PMID template to TableEdit version

2013-09-15T04:30:10Z

change PMID template to TableEdit version

← Older revision		Revision as of 04:30, 15 September 2013
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	!align=left \|Citation		!align=left \|Citation
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	'''~~No author listed~~''' (2006) The type III flagellar export specificity switch is dependent on FliK ruler and a molecular clock. ''J. Mol. Biol.'' '''359''':466-77		'''Moriya, N, Minamino, T, Hughes, KT, Macnab, RM and Namba, K''' (2006) The type III flagellar export specificity switch is dependent on FliK ruler and a molecular clock. ''J. Mol. Biol.'' '''359''':466-77
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	!align=left \|Abstract		!align=left \|Abstract

imported>Wikientrybot: replace GO_table_reference with annotationlinks

2013-09-01T18:53:07Z

replace GO_table_reference with annotationlinks

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+<annotationlinks/>
 ==EcoliWiki Links {{HelpIcon|Help:Literature}} ==

imported>Wikientrybot: change PMID template to TableEdit version

2013-09-01T18:53:07Z

change PMID template to TableEdit version

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-|{{TableHeadingColor}} |'''Abstract''' || Salmonella flagellar hook length is controlled at the level of export substrate specificity of the FlhB component of the type III flagellar export apparatus. FliK is believed to be the hook length sensor and interacts with FlhB to change its export specificity upon hook completion. To find properties of FliK expected of such a molecular ruler, we assayed binding of FliK to the hook and found that the N-terminal domain of FliK (FliK(N)) bound to the hook-capping protein FlgD with high affinity and to the hook protein FlgE with low affinity. To investigate a possible role of FlgE in hook length control, flgE mutants with partially impaired motility were isolated and analyzed. Eight flgE mutants obtained all formed flagellar filaments. The mutants produced significantly shorter hooks while the hook-type substrates such as FlgE, FliK and FlgD were secreted in large amounts, suggesting defective hook assembly with the mutant FlgE proteins. Upon overexpression, mutant FlgEs produced hooks of normal length and wild-type FlgE produced longer hooks. These results suggest that hook length is dependent on the hook polymerization rate and that the start of hook polymerization initiates a "time countdown" for the specificity switch to occur or for significant slow down of rod/hook-type export after hook length reaches around 55 nm for later infrequent FliK(C)-FlhB(C) interaction. We propose that FliK(N) acts as a flexible tape measure, but that hook length is also dependent on the hook elongation rate and a switch timing mechanism.
+!align=left  |Citation
-</noinclude>
+||
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-|{{TableHeadingColor}} nowrap |'''Links''' ||  [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16630628 PubMed]
+!align=left  |Keywords
 |}
+<!--box uid=d41d8cd98f00b204e9800998ecf8427e.59501.D52238d1327dd9-->
 ==Significance {{HelpIcon|Help:Literature}} ==
 {{LitSignificance}}

127.0.0.1: /Volumes/r3/t3/ul/working/touchTables/touch_all_tables.php

2010-06-17T20:33:47Z

/Volumes/r3/t3/ul/working/touchTables/touch_all_tables.php

← Older revision		Revision as of 20:33, 17 June 2010
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	\|-		\|- {{table heading style}}
	!\|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status		!\|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

127.0.0.1: Update TableEdit tables.

2010-01-09T04:26:32Z

Update TableEdit tables.

← Older revision		Revision as of 04:26, 9 January 2010
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	\|- ~~{{table heading style}}~~		\|-
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imported>Wikientrybot: Fix links due to TableEditLinks.php changes.

2009-02-20T03:32:20Z

Fix links due to TableEditLinks.php changes.

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+<!--
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127.0.0.1: Edited by wikibot

2008-04-30T11:54:59Z

Edited by wikibot

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	==Annotations {{HelpIcon\|Help:Literature}}==		==Annotations {{HelpIcon\|Help:Literature}}==
	<!--box uid=63ce1649aab8b3180235b0af7618f667.0.B46a6337b2cc6f-->		<!--box uid=63ce1649aab8b3180235b0af7618f667.0.B46a6337b2cc6f-->
	[{{SERVER}}~~/colipedia~~/index.php/Special:TableEdit?id=63ce1649aab8b3180235b0af7618f667.0.B46a6337b2cc6f&page=0&pagename={{FULLPAGENAMEE}}&type=0 Add GO annotations]		[{{SERVER}}{{SCRIPTPATH}}/index.php/Special:TableEdit?id=63ce1649aab8b3180235b0af7618f667.0.B46a6337b2cc6f&page=0&pagename={{FULLPAGENAMEE}}&type=0 Add GO annotations]
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127.0.0.1: Edited by wikibot

2008-04-25T22:03:42Z

Edited by wikibot

← Older revision		Revision as of 22:03, 25 April 2008
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	\|{{TableHeadingColor}} nowrap \|'''Links''' \|\| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16630628 PubMed]		\|{{TableHeadingColor}} nowrap \|'''Links''' \|\| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16630628 PubMed]
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	==Significance {{HelpIcon\|Help:Literature}} ==		==Significance {{HelpIcon\|Help:Literature}} ==
	{{LitSignificance}}		{{LitSignificance}}
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	==Annotations {{HelpIcon\|Help:Literature}}==		==Annotations {{HelpIcon\|Help:Literature}}==
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	==EcoliWiki Links {{HelpIcon\|Help:Literature}} ==		==EcoliWiki Links {{HelpIcon\|Help:Literature}} ==

66.249.70.172: New PMID: Page!

2007-07-24T17:14:35Z

New PMID: Page!

New page

<protect>
{{RightTOC}}

<span style = 'font-size: large'> '''Moriya, N, Minamino, T, Hughes, KT, Macnab, RM and Namba, K''' (2006) The type III flagellar export specificity switch is dependent on FliK ruler and a molecular clock.''J. Mol. Biol.'' '''359''':466-77</span>

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || Salmonella flagellar hook length is controlled at the level of export substrate specificity of the FlhB component of the type III flagellar export apparatus. FliK is believed to be the hook length sensor and interacts with FlhB to change its export specificity upon hook completion. To find properties of FliK expected of such a molecular ruler, we assayed binding of FliK to the hook and found that the N-terminal domain of FliK (FliK(N)) bound to the hook-capping protein FlgD with high affinity and to the hook protein FlgE with low affinity. To investigate a possible role of FlgE in hook length control, flgE mutants with partially impaired motility were isolated and analyzed. Eight flgE mutants obtained all formed flagellar filaments. The mutants produced significantly shorter hooks while the hook-type substrates such as FlgE, FliK and FlgD were secreted in large amounts, suggesting defective hook assembly with the mutant FlgE proteins. Upon overexpression, mutant FlgEs produced hooks of normal length and wild-type FlgE produced longer hooks. These results suggest that hook length is dependent on the hook polymerization rate and that the start of hook polymerization initiates a "time countdown" for the specificity switch to occur or for significant slow down of rod/hook-type export after hook length reaches around 55 nm for later infrequent FliK(C)-FlhB(C) interaction. We propose that FliK(N) acts as a flexible tape measure, but that hook length is also dependent on the hook elongation rate and a switch timing mechanism.
</noinclude>
|-
|{{TableHeadingColor}} nowrap |'''Links''' || [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16630628 PubMed]
|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>
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</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==References==
{{RefHelp}}
<references/>