basR:Quickview

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Standard Name

basR

Gene Synonym(s)

ECK4106, b4113, JW4074, pmrA[1], pmrA

Product Desc.

DNA-binding response regulator in two-component regulatory system with BasS[1]

Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)[2]

Product Synonyms(s)

PmrA[3][1], B4113[3][1], ECK4106, JW4074, pmrA, b4113

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): basRS[3]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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Notes

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BasS is the cognate sensor protein of the BasSR two-component system. Constitutive allele basR53 (pmrA53) confers polymyxin B resistance and deoxycholate hypersensitivity. EvgAS regulon. BasSR confers resistance to Fe(III)-mediated killing.The BasSR regulon has been primarily characterized in Salmonella; unlike E. coli, Salmonella also activates PmrAB(BasSR) in low Mg(2+), mediated by PhoPQ and the PmrD protein.[2]



References

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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. 3.0 3.1 3.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7