frc:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
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Standard Name

frc

Gene Synonym(s)

ECK2370, b2374, JW2371, yfdW[1], yfdW

Product Desc.

formyl-CoA transferase[2][3];

Component of predicted formyl-CoA transferase[3]

Formyl CoA transferase, oxalate catabolism; dimeric[4]
Product Synonyms(s)

formyl-CoA transferase, NAD(P)-binding[1], B2374[2][1], YfdW[2][1], Frc[2][1] , ECK2370, JW2371, yfdW, b2374

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): frc[2]

Regulation/Activity
Quick Links

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Notes

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Orthologous to O. formigenes Frc. EvgAS regulon. The frc-oxc-yfdVE operon is adjacent and convergent on evgAS. Uninduced level is probably low since Sidhu et al. found no activity in E. coli host cells. Two monomers of Frc assemble as interlaced rings, defining the CoA binding site at their interface. Frc binds formylCoA and oxalate. AFMB Structural Genomics ASG target No. 104 (http://afmb.cnrs-mrs.fr/article171.html).[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.