yafQ:Quickview

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References Suggestions

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Standard Name

yafQ

Gene Synonym(s)

ECK0226, b0225, JW0215[1], JW0215

Product Desc.

predicted toxin of the YafQ-DinJ toxin-antitoxin system[2]; toxin of the YafQ-DinJ toxin-antitoxin system[3]

Toxin of TA pair YafQ/DinJ, inhibitor of translation[4]

Product Synonyms(s)

predicted toxin of the YafQ-DinJ toxin-antitoxin system[1], B0225[2][1], YafQ[2][1] , ECK0226, JW0215, b0225

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yafQ[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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YafQ is homologous to the RelE toxin, which inhibits translation as a sequence-specific mRNA endoribonuclease. Coexpression of DinJ with YafQ blocks the growth inhibitory effect of YafQ (Motiejunaite, 2007; Szekeres, 2007). YafQ overexpression does not inhibit rich media growth completely (but does block growth on M9 glycerol plates) or cause a loss in CFU, as do the other toxins (Motiejunaite, 2007). DinJ and YafQ form a complex (Motiejunaite, 2007).[4] YafQ associates with ribosomes and stimulates mRNA cleavage at the A site[5]



References

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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Prysak, MH et al. (2009) Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Mol. Microbiol. 71 1071-87 PubMed