EcoliWiki - User contributions [en]

ftsL:Expression

2011-12-12T17:57:46Z

Whitley: /* Notes */

ftsL:Expression

2011-12-12T17:57:21Z

Whitley: /* Notes */

ftsL:Expression

2011-12-12T17:56:19Z

Whitley: /* Notes */

ftsW:Gene Product(s)

2011-12-09T14:56:07Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsW}}{{Tab|Gene|ftsW}}{{Tab On|Gene Product(s)|ftsW}}{{Tab|Expression|ftsW}}{{Tab|Evolution|ftsW}}{{Tab|On One Page|ftsW}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="Q46aa1b1819830" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsW
|-
!align=left {{table heading style}} |Synonyms
||
''integral membrane protein involved in stabilizing FstZ ring during cell division<ref name='LIB:Riley_2006'/>, B0089<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsW<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0090, JW0087, b0089''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsW<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Stabilizes FtsZ ring, membrane protein; faciltates septal petidoglycan synthesis by recruiting the cognate FtsI transpeptidase; SEDS protein<ref name='LIB:EcoGene'/>

During cell division FtsW is localized at the septum. <ref name='PMID:9603865'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19662.Q46aa1b1819830&page=19662&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="I46aa1b190dc84" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005515
|
protein binding
|
PMID:18165305
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007047
|
cellular cell wall organization
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0961
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000910
|
cytokinesis
|
PMID:9006034
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001182
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9006034
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018365
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0008360
|
regulation of cell shape
|
PMID:9006034
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032155
|
cell division site part
|
PMID:9603865
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0008360
|
regulation of cell shape
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0133
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9603865
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0009252
|
peptidoglycan biosynthetic process
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR013437
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:18165305
|
IDA: Inferred from Direct Assay
|

|
F
|
FtsW was shown to interact with [[mtgA:Gene_Product(s)|MtgA]] using a 2-hybrid system.
|
complete
|-
|

|
GO:0009252
|
peptidoglycan biosynthetic process
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0573
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0472
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001182
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR013437
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018365
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9909
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsN

|
F
|

|
complete

|- class="tableEdit_footer"
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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="P46aa1b1b91ec2" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
[[rpsP:Gene_Product(s)|rpsP]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[groS:Gene_Product(s)|groS]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[rpsT:Gene_Product(s)|rpsT]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[rplP:Gene_Product(s)|rplP]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[phoA:Gene_Product(s)|phoA]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
FtsI
|
FtsW activity in peptidoglycan synthesis at the septum is dependent on FtsI
|
PMID:11807049
|

|-
|
Protein
|
FtsZ
|
ftsW201 is hypersensitive to excess levels of FtsZ at permissive temperatures
|
PMID:7961485
|

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="Q46aa1b1c41983" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 10 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
plasma membrane
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19662.Q46aa1b1c41983&page=19662&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="T46aa1b1da6260" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10344-MONOMER at EcoCyc]
<pre>MRLSLPRLKM PRLPGFSILV WISTALKGWV MGSREKDTDS LIMYDRTLLW LTFGLAAIGF
IMVTSASMPI GQRLTNDPFF FAKRDGVYLI LAFILAIITL RLPMEFWQRY SATMLLGSII
LLMIVLVVGS SVKGASRWID LGLLRIQPAE LTKLSLFCYI ANYLVRKGDE VRNNLRGFLK
PMGVILVLAV LLLAQPDLGT VVVLFVTTLA MLFLAGAKLW QFIAIIGMGI SAVVLLILAE
PYRIRRVTAF WNPWEDPFGS GYQLTQSLMA FGRGELWGQG LGNSVQKLEY LPEAHTDFIF
AIIGEELGYV GVVLALLMVF FVAFRAMSIG RKALEIDHRF SGFLACSIGI WFSFQALVNV
GAAAGMLPTK GLTLPLISYG GSSLLIMSTA IMMLLRIDYE TRLEKAQAFV RGSR</pre>
|-
!align=left {{table heading style}} |Length
||
414
|-
!align=left {{table heading style}} |Mol. Wt
||
45.989 kDa
|-
!align=left {{table heading style}} |pI
||
10.2 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
71,390 - 71,640 (calc based on 11 Y, 10 W, and 2 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19662.T46aa1b1da6260&page=19662&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa1b1e0a119" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
46..403
|
[http://pfam.janelia.org/family/PF01098 PF01098 Cell cycle protein]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsW}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="T46a730c5b9d56" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsW
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0ABG4 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19662.T46a730c5b9d56&page=19662&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="M46aa1b1e9c845" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19662.M46aa1b1e9c845&page=19662&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="B46aa1b1ee5434" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128082 GI:16128082]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_414631.1 GeneID:946322]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0000320&formSubmitReturn=1 ASAP:ABE-0000320]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0ABG4 UniProtKB/Swiss-Prot:P0ABG4]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10344 ECOCYC:EG10344]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG10344 EcoGene:EG10344]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=946322 GeneID:946322]
|
Escherichia coli str. K-12 substr. MG1655

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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="M46a730c81fe60" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19662.M46a730c81fe60&page=19662&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsW:Quickview

2011-12-09T14:56:06Z

Whitley: Updating New_Quickview_Table table.

ftsW:Quickview

2011-12-09T14:56:05Z

Whitley: Updating New_Quickview_Table table.

ftsI:Expression

2011-12-09T14:51:35Z

Whitley: /* Notes */

ftsK:Expression

2011-12-06T18:53:54Z

Whitley: /* Notes */

ftsK:Expression

2011-12-06T18:50:32Z

Whitley: /* Notes */

ftsK:Gene Product(s)

2011-12-06T18:48:29Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab|Gene|ftsK}}{{Tab On|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="R46aa4982a88b9" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsK
|-
!align=left {{table heading style}} |Synonyms
||
''DNA-binding membrane protein required for chromosome resolution and partitioning<ref name='LIB:Riley_2006'/>, B0890<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DinH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dinH, ECK0881, JW0873, b0890''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsK <ref name='PMID:9723913'/><ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]<ref name='LIB:EcoCyc11.1'/><ref name='PMID:12034757'/>

DNA translocase at septal ring sorting daughter chromsomes<ref name='LIB:EcoGene'/><ref name='PMID:12034757'/>

Couples cell division and chromosome segregation. <ref name='PMID:1596604'/>

Required at an early step in septation. <ref name='PMID:9723913'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21613.R46aa4982a88b9&page=21613&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="S46aa49840dbe9" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051301
|
cell division
|
PMID:9721304
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:7592387
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:17805344
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in ''parC(ts)'' and ''parE(ts)'' cells
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:10922461
|
EXP: Inferred from Experiment
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0159
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minC EcoliWiki:minD EcoliWiki:minE
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:16301526
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17041598
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17057717
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:9723913
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0071236
|
cellular response to antibiotic
|
PMID:9723913
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
mitomycin C
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:xerC
EcoliWiki:xerD

|
P
|

|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
increases P''uspA'' activity in stationary phase
|
complete
|-
|
Contributes to
|
GO:0006265
|

|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|

|
stimulates Topo IV's ability to relax positively supercoiled DNA
|
complete
|-
|

|
GO:0009651
|
response to salt stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|
Contributes to
|
GO:0007059
|
chromosome segregation
|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|
P
|
stimulates Topo IV's decatenation ability
|
complete
|-
|

|
GO:0000920
|
cytokinetic cell separation
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki: minC | EcoliWiki: minD | EcoliWiki: minE
|
P
|

|
complete

|- class="tableEdit_footer"
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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aa498d2fdf4" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]
|
could be indirect
|

|

|-
|
Protein
|
aceE 
|

|
PMID:15690043
|
Experiment(s):EBI-888719 
|-
|
Protein
|
[[rpsJ:Gene_Product(s)|rpsJ]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[yfiD:Gene_Product(s)|yfiD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
ParC subunit of Topo IV
|
PMID:12939258
|

|

|-
|
Protein
|
Either subunit of the XerCD Recombinase
|

|
PMID:19854947
|
Triplex Displacement Assays
|-
|
Protein
|
FtsZ and FtsA
|
FtsK localization depends on FtsZ and FtsA prior localization
|
PMID:9723913
|

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| {{Prettytable}} id="M46aa498e3f43d" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
Inner membrane
|
GFP fusion localization
|
PMID:9495771
|
Signal sequence in the N-terminal domain of the protein
|

|-
|
Inner membrane
|
PhoA and beta-gal assays
|
PMID:10922461
|

|

|-
|
Cytosol
|
FtsK (818-1329)
|
Microscopy
|
PMID:11114887
|

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa498fab9bb" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6464-MONOMER at EcoCyc]
<pre>MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD</pre>
|-
!align=left {{table heading style}} |Length
||
1,329
|-
!align=left {{table heading style}} |Mol. Wt
||
146.661 kDa
|-
!align=left {{table heading style}} |pI
||
4.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

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|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa4990131be" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
947..1161
|
[http://pfam.janelia.org/family/PF01580 PF01580 FtsK/SpoIIIE family]
|

|
PMID:19920124
|-
|
Domain
|
1261..1327
|
[http://pfam.janelia.org/family/PF09397 PF09397 Ftsk gamma domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsK}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="S46a7db57eacb5" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsK
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P46889 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
* Membrane topology studies using ''phoA'' and ''lacZ'' fusions are described in Dorazi ''et al.''(2000)<ref name='PMID:10922461'/>

* Crystal structure of ''P. aeruginosa'' FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe ''et al.'' (2008)<ref name='PMID:18722176'/>.

*FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation<ref name='PMID:17511809'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa4990ac348" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
raised against FtsK(447-729)
|
isolated from rabbit <ref name='PMID:9723913'/>
|-
|
Purification protocol
|

|
*PMID:18722176
*PMID:20081205
*PMID:12939258
*PMID:11832210

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa499104897" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128857 GI:16128857]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415410.1 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003027&formSubmitReturn=1 ASAP:ABE-0003027]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P46889 UniProtKB/Swiss-Prot:P46889]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="R46a7db5b75b2f" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsK:Gene Product(s)

2011-12-06T18:33:04Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab|Gene|ftsK}}{{Tab On|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="R46aa4982a88b9" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsK
|-
!align=left {{table heading style}} |Synonyms
||
''DNA-binding membrane protein required for chromosome resolution and partitioning<ref name='LIB:Riley_2006'/>, B0890<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DinH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dinH, ECK0881, JW0873, b0890''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsK <ref name='PMID:9723913'/><ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]<ref name='LIB:EcoCyc11.1'/><ref name='PMID:12034757'/>

DNA translocase at septal ring sorting daughter chromsomes<ref name='LIB:EcoGene'/><ref name='PMID:12034757'/>

Couples cell division and chromosome segregation. <ref name='PMID:1596604'/>

Required at an early step in septation. <ref name='PMID:9723913'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="S46aa49840dbe9" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051301
|
cell division
|
PMID:9721304
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:7592387
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:17805344
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in ''parC(ts)'' and ''parE(ts)'' cells
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:10922461
|
EXP: Inferred from Experiment
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0159
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minC EcoliWiki:minD EcoliWiki:minE
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:16301526
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17041598
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17057717
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:9723913
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0071236
|
cellular response to antibiotic
|
PMID:9723913
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
mitomycin C
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:xerC
EcoliWiki:xerD

|
P
|

|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
increases P''uspA'' activity in stationary phase
|
complete
|-
|
Contributes to
|
GO:0006265
|

|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|

|
stimulates Topo IV's ability to relax positively supercoiled DNA
|
complete
|-
|

|
GO:0009651
|
response to salt stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|
Contributes to
|
GO:0007059
|
chromosome segregation
|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|
P
|
stimulates Topo IV's decatenation ability
|
complete
|-
|

|
GO:0000920
|
cytokinetic cell separation
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki: minC | EcoliWiki: minD | EcoliWiki: minE
|
P
|

|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aa498d2fdf4" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]
|
could be indirect
|

|

|-
|
Protein
|
aceE 
|

|
PMID:15690043
|
Experiment(s):EBI-888719 
|-
|
Protein
|
[[rpsJ:Gene_Product(s)|rpsJ]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[yfiD:Gene_Product(s)|yfiD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
ParC subunit of Topo IV
|
PMID: 12939258
|

|

|-
|
Protein
|
Either subunit of the XerCD Recombinase
|

|
PMID:19854947
|
Triplex Displacement Assays

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| {{Prettytable}} id="M46aa498e3f43d" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
Inner membrane
|
GFP fusion localization
|
PMID:9495771
|
Signal sequence in the N-terminal domain of the protein
|

|-
|
Inner membrane
|
PhoA and beta-gal assays
|
PMID:10922461
|

|

|-
|
Cytosol
|
FtsK (818-1329)
|
Microscopy
|
PMID:11114887
|

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa498fab9bb" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6464-MONOMER at EcoCyc]
<pre>MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD</pre>
|-
!align=left {{table heading style}} |Length
||
1,329
|-
!align=left {{table heading style}} |Mol. Wt
||
146.661 kDa
|-
!align=left {{table heading style}} |pI
||
4.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa4990131be" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
947..1161
|
[http://pfam.janelia.org/family/PF01580 PF01580 FtsK/SpoIIIE family]
|

|
PMID:19920124
|-
|
Domain
|
1261..1327
|
[http://pfam.janelia.org/family/PF09397 PF09397 Ftsk gamma domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsK}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="S46a7db57eacb5" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsK
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P46889 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
* Membrane topology studies using ''phoA'' and ''lacZ'' fusions are described in Dorazi ''et al.''(2000)<ref name='PMID:10922461'/>

* Crystal structure of ''P. aeruginosa'' FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe ''et al.'' (2008)<ref name='PMID:18722176'/>.

*FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation<ref name='PMID:17511809'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa4990ac348" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
raised against FtsK(447-729)
|
isolated from rabbit <ref name='PMID:9723913'/>
|-
|
Purification protocol
|

|
*PMID:18722176
*PMID:20081205
*PMID:12939258
*PMID:11832210

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa499104897" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128857 GI:16128857]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415410.1 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003027&formSubmitReturn=1 ASAP:ABE-0003027]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P46889 UniProtKB/Swiss-Prot:P46889]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="R46a7db5b75b2f" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsK:Quickview

2011-12-06T18:32:58Z

Whitley: Updating New_Quickview_Table table.

ftsN:Gene Product(s)

2011-12-06T17:43:52Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsN}}{{Tab|Gene|ftsN}}{{Tab On|Gene Product(s)|ftsN}}{{Tab|Expression|ftsN}}{{Tab|Evolution|ftsN}}{{Tab|On One Page|ftsN}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="N46ab0eb18107e" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsN
|-
!align=left {{table heading style}} |Synonyms
||
''essential cell division protein<ref name='LIB:Riley_2006'/>, B3933<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsgA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3925, JW3904, msgA, b3933''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Cell division and growth; multicopy suppresses ftsA12<ref name='LIB:EcoGene'/>

Enhances the integrity and activity of Z ring. <ref name='PMID:17542921'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="W46ab0eb2a71da" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000910
|
cytokinesis
|
PMID:9282742
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9282742
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
PMID:9282742
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:8509333
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:18165305
|
IGI: Inferred from Genetic Interaction
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0005624
|
membrane fraction
|
PMID:8509333
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:18165305
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:mtgA

|
F
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0472
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|

|

|

|
P
|

|
Missing: evidence, reference
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9906
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0033205
|
cell cycle cytokinesis
|
PMID:8509333
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0044457
|
cell septum part
|
PMID:9282742
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsN

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:zapA

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsW

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsI

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28505.W46ab0eb2a71da&page=28505&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="F46ab0eb5e98e2" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
ynaE 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
rpsI 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
rraA 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
yhaJ 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
ydfK 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
rhaD 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
gadW 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
rplQ 
|

|
PMID:16606699
|
Experiment(s):EBI-1147095 
|-
|
Protein
|
ftsA12(ts), ftsQ1(ts), and ftsI23(ts)
|
FtsN suppresses these mutations suggesting that FtsN interacts and stabilizes these parts of division
|
PMID:8631709
PMID:9282742
PMID:8509333
|

|-
|
Protein
|
ftsK
|
FtsN suppresses mutations of ftsK allowing cell division to occur
|
PMID:9721304
|

|-
|
Protein
|
FtsI and FtsQ

|
these proteins are required for the recruiting of FtsN

Septal ring localization depends on FtsI
|
PMID:9282742
|

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="I46ab0eb6c3e6c" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|

|

|

|

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="C46ab0eb876b7d" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11529-MONOMER at EcoCyc]
<pre>MAQRDYVRRS QPAPSRRKKS TSRKKQRNLP AVSPAMVAIA AAVLVTFIGG LYFITHHKKE
ESETLQSQKV TGNGLPPKPE ERWRYIKELE SRQPGVRAPT EPSAGGEVKT PEQLTPEQRQ
LLEQMQADMR QQPTQLVEVP WNEQTPEQRQ QTLQRQRQAQ QLAEQQRLAQ QSRTTEQSWQ
QQTRTSQAAP VQAQPRQSKP ASSQQPYQDL LQTPAHTTAQ SKPQQAAPVA RAADAPKPTA
EKKDERRWMV QCGSFRGAEQ AETVRAQLAF EGFDSKITTN NGWNRVVIGP VKGKENADST
LNRLKMAGHT NCIRLAAGG</pre>
|-
!align=left {{table heading style}} |Length
||
319
|-
!align=left {{table heading style}} |Mol. Wt
||
35.791 kDa
|-
!align=left {{table heading style}} |pI
||
10.6 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
33,460 - 33,710 (calc based on 4 Y, 5 W, and 2 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="F46ab0eb8edc2e" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
244..315
|
[http://pfam.janelia.org/family/PF05036 PF05036 Sporulation related domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="N46ab0eb95d1c1" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsN
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P29131 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="I46ab0eba51655" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28505.I46ab0eba51655&page=28505&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="J46ab0ebabac0d" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16131771 GI:16131771]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_418368.1 GeneID:948428]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0012850&formSubmitReturn=1 ASAP:ABE-0012850]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P29131 UniProtKB/Swiss-Prot:P29131]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11529 ECOCYC:EG11529]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG11529 EcoGene:EG11529]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=948428 GeneID:948428]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="E46a896d0acbec" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28505.E46a896d0acbec&page=28505&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsZ:Expression

2011-12-05T19:22:31Z

Whitley: /* Notes */

ftsL:Expression

2011-12-05T18:46:13Z

Whitley: /* Notes */

ftsL:Gene Product(s)

2011-12-05T18:40:16Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsL}}{{Tab|Gene|ftsL}}{{Tab On|Gene Product(s)|ftsL}}{{Tab|Expression|ftsL}}{{Tab|Evolution|ftsL}}{{Tab|On One Page|ftsL}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="O46aa1aa40f3d4" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsL
|-
!align=left {{table heading style}} |Synonyms
||
''membrane bound cell division protein at septum containing leucine zipper motif<ref name='LIB:Riley_2006'/>, B0083<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YabD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MraR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0084, JW0081, mraR, yabD, b0083''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Cell division and growth, membrane protein<ref name='LIB:EcoGene'/>

Localizes proteins to septal machinery during cell division. <ref name='PMID:21708137'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="C46aa1aa50a86a" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007082
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011922
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0472
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007082
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011922
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9906
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011922
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="I46aa1aa78eff7" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
[[rplD:Gene_Product(s)|rplD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[rluA:Gene_Product(s)|rluA]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="I46aa1aa83e5cd" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|-
|
Inner membrane
|

|
PMID:1332942
|
[http://www.york.ac.uk/res/thomas/Echolocation.cfm?EB_SubLocID=EB1078 EchoLocation:ftsL]
|
Membrane anchored

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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa1aa9a1cbf" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11086-MONOMER at EcoCyc]
<pre>MISRVTEALS KVKGSMGSHE RHALPGVIGD DLLRFGKLPL CLFICIILTA VTVVTTAHHT
RLLTAQREQL VLERDALDIE WRNLILEENA LGDHSRVERI ATEKLQMQHV DPSQENIVVQ K</pre>
|-
!align=left {{table heading style}} |Length
||
121
|-
!align=left {{table heading style}} |Mol. Wt
||
13.626 kDa
|-
!align=left {{table heading style}} |pI
||
6.9 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
5,500 - 5,750 (calc based on Y, 1 W, and 2 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19647.R46aa1aa9a1cbf&page=19647&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="Q46aa1aaa05984" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
24..120
|
[http://pfam.janelia.org/family/PF04999 PF04999 Cell division protein FtsL]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="H46a73058d7ade" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsL
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0AEN4 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="P46aa1aaa97f00" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19647.P46aa1aaa97f00&page=19647&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aa1aaae0a89" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128076 GI:16128076]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_414625.1 GeneID:944803]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0000306&formSubmitReturn=1 ASAP:ABE-0000306]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0AEN4 UniProtKB/Swiss-Prot:P0AEN4]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11086 ECOCYC:EG11086]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG11086 EcoGene:EG11086]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=944803 GeneID:944803]
|
Escherichia coli str. K-12 substr. MG1655

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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Z46a7305b3acca" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19647.Z46a7305b3acca&page=19647&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsL:Quickview

2011-12-05T18:40:12Z

Whitley: Updating New_Quickview_Table table.

ftsL:Quickview

2011-12-05T18:40:03Z

Whitley: Updating New_Quickview_Table table.

ftsK:Gene

2011-12-05T18:35:04Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab On|Gene|ftsK}}{{Tab|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Interactions | Genetic Interactions]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="D46a9bb0157a6c" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''ftsK''
|-
!align=left {{table_heading_style}} |Mnemonic
||
filamentation temperature sensitive
Filamentation, temperature sensitive
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>, dinH'',
usoM <ref name='PMID:9294449'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.D46a9bb0157a6c&page=12339&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="V46a9bb01cfcb0" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
20.1 minutes 
|
MG1655: 932447..936436 <gbrowseImage>
name=NC_000913:932447..936436
source=MG1655
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=G6464 EcoCyc]
{{GBrowseLink|MG1655|NC_000913|931447|937436|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|MG1655|NC_000913|932447|936436|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=G6464 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 950282..954310 <gbrowseImage>
name=NC_012967:950282..954310
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|950282|954310|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|950282|954310|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 835415..839404 <gbrowseImage>
name=NC_012759:835415..839404
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|NC_012759|835415|839404|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|NC_012759|835415|839404|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 933646..937635 <gbrowseImage>
name=AC_000091:933646..937635
source=W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|W3110|AC_000091|932646|938635|GBrowse(W3110)}}
|
{{GBrowseFastaLink|W3110|AC_000091|933646|937635|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 986375..990364 <gbrowseImage>
name=NC_010473:986375..990364
source=DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|DH10B|NC_010473|978397|998342|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|DH10B|NC_010473|978397|998342|FASTA Dump}}

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="U46a9bb0279a81" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.U46a9bb0279a81&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="B46a9bb02b9f16" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔLC
|

|

|

|

|
PMID:15522074
|

|
Carries a deletion of FtsK L and FtsK C
|-
|
''ftsK''G80A
|

|
G80A
|

|
In Toe44; loss of function under extreme conditions
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
ftsKE58A
|

|
E58A
|

|
Loss of function
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
NC
|

|

|

|

|
PMID:15522074
|
Barre
|
Deletion of the FtsK Linker
|-
|
NL hi C
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H. influenzae'' FtsK regions
|-
|
ftsK A
|

|
K997A
|

|

|
PMID:15522074
|
Barre
|
Carries a single point mutation in the walker A motif of FtsK C
|-
|
NLC hi
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H.influenzae'' FtsK regions
|-
|
ftsk::cat1
|

|

|

|

|
PMID:9721304
|
Donachie
Sheratt

|
only expresses the NTD due to a Cm resistance cassette at nt 678 of ''ftsK''
|-
|
''ftsk44''
|
missense mutation
|
G80A
|
Growth Phenotype
|
temperature sensitive late stage block in division, but does not affect chromosome replication or segregation

forms long filamentous cells at 42C

|
PMID:7592387

PMID:9721304
|
Donachie
|
this is the allele from the TOE44 strain listed in this table.
|-
|
''ftsK1::cat''
|

|

|

|
abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation
|
* PMID:9294448
* PMID:9829960
|

|
defect in the C-terminus of FtsK
|-
|
''ftsK1::cat ΔmukB''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:9829960
|

|
shown that it must be complemented in trans
|-
|
''ftsK::cat-2''
|
Δ54-2201
|

|

|

|
PMID:9721304
|

|
almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the ''cat'' gene. Lethal- must be complemented ''in trans''
|-
|
''ftsK::cat-Δ5''
|
Δ54-3651
|

|

|

|
PMID:9721304
|

|
this is a deletion of 90% of ''ftsK''
|-
|
''ftsK3531''
|
missense mutation
|

|
Growth Phenotype
|
same phenotype as ''ftsK44''- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:9721304
|

|
suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the ''dacA'' gene, encoding PBP5.
|-
|
''ftsK::cat-Δ2 ΔdacA::kan''
|

|

|
Cell Shape
|
*forms small colonies on plates grows well
*produces a population of misshapen cells in liquid culture
|
PMID:9721304
|

|

|-
|
''ftsK::cat-Δ5 Δdac::kan''
|

|

|

|
synthetically lethal
|
PMID:9721304
|

|

|-
|
''ftsKC priA2::kan''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:11459954

|

|

|-
|
''ftsK1::cat ΔminB''
|

|

|
Growth Phenotype
|
chains of minicells generated (many of which contained DNA)
|
PMID:9829960
|

|

|-
|
''ftsK100''
|

|
K997A
|

|
ATP mutant
|
PMID:18363794
|

|

|-
|
ftsK10
|

|

|
Growth Phenotype
|
affects expression form the uspA promoter, results in salt sensitivity, stationary-phase survival is impaired, and cell-cell separation is blocked
|
PMID:9294449
|

|
Also called usoM10
|-
|
ftsK
|
deletion in the c-terminal
|

|
Growth Phenotype
|
inhibits FtsK activity and increases recombination near dif
|
PMID:15916604
PMID:9294449
|

|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===
Deletions that leave the membrane segments intact are viable<ref name='PMID: 9721304'/>. Suppressors of the ''ftsK'' chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.

==Genetic Interactions==
{{BacktoTop}}
<protect>
{{Genetic_interaction_help}}
{| id="X4e04bb9e6c34f" class=" tableEdit Genetic_interaction_table dataTable"
|- {{table_heading_style}}
!|Interactor!!Interaction!!Allele!!Score(s)!!Reference(s)!!Accessions!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.12339.X4e04bb9e6c34f&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Genetic_interaction_table edit table] || || || || || ||
|}
</protect>


===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="R46a9bb0364216" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW0873
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG
|-
|
[[:Category:Kohara_Phage:1F10|1F10]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=214 Genobase]
|
PMID:3038334
|-
|
[[:Category:Kohara_Phage:E6H3|E6H3]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=215 Genobase]
|
PMID:3038334
|-
|
zbh-29::Tn10
|
Linked marker
|
CAG18493 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39400 CGSC7353]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: % <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbi-29::Tn10
|-
|
zca-1230::Tn10
|
Linked marker
|
CAG18478 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39407 CGSC7356]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 61% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbj-1230::Tn10
|-
|
W3110::P''lac-ftsK''
|
Strain
|

|
Depletion Strain<ref name='PMID:9723913'/>
|-
|
pWL71
|
Plasmid Clone
|
Pbad-FtsK(1-202)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain<ref name='PMID:9723913'/>
|-
|
pWL72
|
Plasmid Clone
|
Pbad-FtsK(1-211)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL73
|
Plasmid Clone
|
Pbad-FtsK(1-251)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL74
|
Plasmid Clone
|
Pbad-FtsK(1-644)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL75
|
Plasmid Clone
|
Pbad-FtsK(1-1329)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL76
|
Plasmid Clone
|
Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK
|
Cannot complement the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pFtsK-PhoA plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''phoA'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFtsK-LacZ plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''lacZ'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFLAG-FtsK plasmids
|
Plasmid Clone
|

|
This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG<ref name='PMID:11114887'/>.
|-
|
MA3
|
Strain
|
AB1157''ftsK''
|
PMID:10523315
|-
|
GR51
|
Strain
|
AB1157''xerCftsK''
|
PMID:10523315
|-
|
GR59
|
Strain
|
AB1157''ftsK recA56 srl::Tn10''
|
PMID:10523315
|-
|
FC1
|
Strain
|
AB1157, ''ftsK100'' K997A (ATP mutant), CmR
|
PMID:18363794
|-
|
FtsK-YFP
|
Plasmid Clone
|
*low-copy expression vectors derived from pSC101
*Spectinomycin resistance gene
|
PMID:18363794
|-
|
FtsKΔγ
|
Plasmid Clone
|
FtsK50C deleted from residue 1248
|
PMID:19854947

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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46a9bb03edc16" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI] ([[NCBI|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

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<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Y46a6d85840482" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

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|}


<noinclude><protect>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Genes not in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:fts genes]][[Category:Gene_List:DH10B]][[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]

ftsK:Gene Product(s)

2011-12-05T18:29:17Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab|Gene|ftsK}}{{Tab On|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="R46aa4982a88b9" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsK
|-
!align=left {{table heading style}} |Synonyms
||
''DNA-binding membrane protein required for chromosome resolution and partitioning<ref name='LIB:Riley_2006'/>, B0890<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DinH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dinH, ECK0881, JW0873, b0890''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsK <ref name='PMID:9723913'/><ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]<ref name='LIB:EcoCyc11.1'/><ref name='PMID:12034757'/>

DNA translocase at septal ring sorting daughter chromsomes<ref name='LIB:EcoGene'/><ref name='PMID:12034757'/>

Couples cell division and chromosome segregation. <ref name='PMID:1596604'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="S46aa49840dbe9" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051301
|
cell division
|
PMID:9721304
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:7592387
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:17805344
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in ''parC(ts)'' and ''parE(ts)'' cells
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:10922461
|
EXP: Inferred from Experiment
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0159
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minC EcoliWiki:minD EcoliWiki:minE
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:16301526
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17041598
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17057717
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:9723913
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0071236
|
cellular response to antibiotic
|
PMID:9723913
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
mitomycin C
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:xerC
EcoliWiki:xerD

|
P
|

|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
increases P''uspA'' activity in stationary phase
|
complete
|-
|
Contributes to
|
GO:0006265
|

|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|

|
stimulates Topo IV's ability to relax positively supercoiled DNA
|
complete
|-
|

|
GO:0009651
|
response to salt stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|
Contributes to
|
GO:0007059
|
chromosome segregation
|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|
P
|
stimulates Topo IV's decatenation ability
|
complete
|-
|

|
GO:0000920
|
cytokinetic cell separation
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki: minC | EcoliWiki: minD | EcoliWiki: minE
|
P
|

|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aa498d2fdf4" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]
|
could be indirect
|

|

|-
|
Protein
|
aceE 
|

|
PMID:15690043
|
Experiment(s):EBI-888719 
|-
|
Protein
|
[[rpsJ:Gene_Product(s)|rpsJ]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[yfiD:Gene_Product(s)|yfiD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
ParC subunit of Topo IV
|
PMID: 12939258
|

|

|-
|
Protein
|
Either subunit of the XerCD Recombinase
|

|
PMID:19854947
|
Triplex Displacement Assays

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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| {{Prettytable}} id="M46aa498e3f43d" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
Inner membrane
|
GFP fusion localization
|
PMID:9495771
|
Signal sequence in the N-terminal domain of the protein
|

|-
|
Inner membrane
|
PhoA and beta-gal assays
|
PMID:10922461
|

|

|-
|
Cytosol
|
FtsK (818-1329)
|
Microscopy
|
PMID:11114887
|

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<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa498fab9bb" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6464-MONOMER at EcoCyc]
<pre>MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD</pre>
|-
!align=left {{table heading style}} |Length
||
1,329
|-
!align=left {{table heading style}} |Mol. Wt
||
146.661 kDa
|-
!align=left {{table heading style}} |pI
||
4.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

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|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa4990131be" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
947..1161
|
[http://pfam.janelia.org/family/PF01580 PF01580 FtsK/SpoIIIE family]
|

|
PMID:19920124
|-
|
Domain
|
1261..1327
|
[http://pfam.janelia.org/family/PF09397 PF09397 Ftsk gamma domain]
|

|
PMID:19920124

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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsK}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="S46a7db57eacb5" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsK
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P46889 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
* Membrane topology studies using ''phoA'' and ''lacZ'' fusions are described in Dorazi ''et al.''(2000)<ref name='PMID:10922461'/>

* Crystal structure of ''P. aeruginosa'' FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe ''et al.'' (2008)<ref name='PMID:18722176'/>.

*FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation<ref name='PMID:17511809'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa4990ac348" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
raised against FtsK(447-729)
|
isolated from rabbit <ref name='PMID:9723913'/>
|-
|
Purification protocol
|

|
*PMID:18722176
*PMID:20081205
*PMID:12939258
*PMID:11832210

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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa499104897" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128857 GI:16128857]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415410.1 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003027&formSubmitReturn=1 ASAP:ABE-0003027]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P46889 UniProtKB/Swiss-Prot:P46889]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="R46a7db5b75b2f" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsK:Quickview

2011-12-05T18:28:51Z

Whitley: Updating New_Quickview_Table table.

ftsK:Gene Product(s)

2011-11-28T19:42:35Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab|Gene|ftsK}}{{Tab On|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="R46aa4982a88b9" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsK
|-
!align=left {{table heading style}} |Synonyms
||
''DNA-binding membrane protein required for chromosome resolution and partitioning<ref name='LIB:Riley_2006'/>, B0890<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DinH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dinH, ECK0881, JW0873, b0890''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsK <ref name='PMID:9723913'/><ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]<ref name='LIB:EcoCyc11.1'/><ref name='PMID:12034757'/>

DNA translocase at septal ring sorting daughter chromsomes<ref name='LIB:EcoGene'/><ref name='PMID:12034757'/>

|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="S46aa49840dbe9" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051301
|
cell division
|
PMID:9721304
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:7592387
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:17805344
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in ''parC(ts)'' and ''parE(ts)'' cells
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:10922461
|
EXP: Inferred from Experiment
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0159
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minC EcoliWiki:minD EcoliWiki:minE
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:16301526
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17041598
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17057717
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:9723913
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0071236
|
cellular response to antibiotic
|
PMID:9723913
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
mitomycin C
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:xerC
EcoliWiki:xerD

|
P
|

|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
increases P''uspA'' activity in stationary phase
|
complete
|-
|
Contributes to
|
GO:0006265
|

|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|

|
stimulates Topo IV's ability to relax positively supercoiled DNA
|
complete
|-
|

|
GO:0009651
|
response to salt stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|
Contributes to
|
GO:0007059
|
chromosome segregation
|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|
P
|
stimulates Topo IV's decatenation ability
|
complete
|-
|

|
GO:0000920
|
cytokinetic cell separation
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki: minC | EcoliWiki: minD | EcoliWiki: minE
|
P
|

|
complete

|- class="tableEdit_footer"
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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aa498d2fdf4" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]
|
could be indirect
|

|

|-
|
Protein
|
aceE 
|

|
PMID:15690043
|
Experiment(s):EBI-888719 
|-
|
Protein
|
[[rpsJ:Gene_Product(s)|rpsJ]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[yfiD:Gene_Product(s)|yfiD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
ParC subunit of Topo IV
|
PMID: 12939258
|

|

|-
|
Protein
|
Either subunit of the XerCD Recombinase
|

|
PMID:19854947
|
Triplex Displacement Assays

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| {{Prettytable}} id="M46aa498e3f43d" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
Inner membrane
|
GFP fusion localization
|
PMID:9495771
|
Signal sequence in the N-terminal domain of the protein
|

|-
|
Inner membrane
|
PhoA and beta-gal assays
|
PMID:10922461
|

|

|-
|
Cytosol
|
FtsK (818-1329)
|
Microscopy
|
PMID:11114887
|

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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa498fab9bb" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6464-MONOMER at EcoCyc]
<pre>MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD</pre>
|-
!align=left {{table heading style}} |Length
||
1,329
|-
!align=left {{table heading style}} |Mol. Wt
||
146.661 kDa
|-
!align=left {{table heading style}} |pI
||
4.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa4990131be" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
947..1161
|
[http://pfam.janelia.org/family/PF01580 PF01580 FtsK/SpoIIIE family]
|

|
PMID:19920124
|-
|
Domain
|
1261..1327
|
[http://pfam.janelia.org/family/PF09397 PF09397 Ftsk gamma domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsK}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="S46a7db57eacb5" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsK
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P46889 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
* Membrane topology studies using ''phoA'' and ''lacZ'' fusions are described in Dorazi ''et al.''(2000)<ref name='PMID:10922461'/>

* Crystal structure of ''P. aeruginosa'' FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe ''et al.'' (2008)<ref name='PMID:18722176'/>.

*FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation<ref name='PMID:17511809'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa4990ac348" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
raised against FtsK(447-729)
|
isolated from rabbit <ref name='PMID:9723913'/>
|-
|
Purification protocol
|

|
*PMID:18722176
*PMID:20081205
*PMID:12939258
*PMID:11832210

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<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa499104897" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128857 GI:16128857]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415410.1 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003027&formSubmitReturn=1 ASAP:ABE-0003027]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P46889 UniProtKB/Swiss-Prot:P46889]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

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<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="R46a7db5b75b2f" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsK:Quickview

2011-11-28T19:42:27Z

Whitley: Updating New_Quickview_Table table.

secY:Gene

2011-11-28T19:04:42Z

Whitley: Table edited by Whitley via TableEdit

ftsH:Expression

2011-11-28T18:22:34Z

Whitley: /* Notes */

ftsH:Gene

2011-11-28T15:46:28Z

Whitley: Table edited by Whitley via TableEdit

ftsH:Gene Product(s)

2011-11-23T17:21:03Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsH}}{{Tab|Gene|ftsH}}{{Tab On|Gene Product(s)|ftsH}}{{Tab|Expression|ftsH}}{{Tab|Evolution|ftsH}}{{Tab|On One Page|ftsH}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="E46aad652e7553" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsH
|-
!align=left {{table heading style}} |Synonyms
||
''protease, ATP-dependent zinc-metallo<ref name='LIB:Riley_2006'/>, B3178<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Std<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TolZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrsC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HflB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsH<ref name='LIB:EcoCyc11.1'/><ref name='LIB:Riley_2006'/> , ECK3167, hflB, JW3145, mrsC, std, tolZ, b3178''
|-
!align=left {{table heading style}} |Product description
||
FtsH<ref name='LIB:EcoCyc10.6'/>; HflB<ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:HflB, integral membrane ATP-dependent zinc metallopeptidase|HflB, integral membrane ATP-dependent zinc metallopeptidase]]<ref name='LIB:EcoCyc11.1'/>

Maintains proper balance of lipopolysaccharide and phospholipid biosunthesis. <ref name='PMID:11523792'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.- 3.4.24.-]<ref name='LIB:Riley_2006'/>

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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="C46aad654732d1" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003593
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0004222
|
metalloendopeptidase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000642
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0004222
|
metalloendopeptidase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005936
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0004222
|
metalloendopeptidase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011546
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000642
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003959
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003960
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011546
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006508
|
proteolysis
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000642
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0008233
|
peptidase activity
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0645
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0008237
|
metallopeptidase activity
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0482
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0008270
|
zinc ion binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011546
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0008270
|
zinc ion binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0862
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011546
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9909
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:7781608
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0006508
|
proteolysis
|
PMID:7781608
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0043273
|
CTPase activity
|
PMID:7781608
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0008270
|
zinc ion binding
|
PMID:7781608
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0030145
|
manganese ion binding
|
PMID:7781608
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
PMID:8444797
|
IDA: Inferred from Direct Assay
|

|
C
|
immunoelectron microscopy
|
complete

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<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="X46aad668ebccf" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:HflB, integral membrane ATP-dependent zinc metallopeptidase|HflB, integral membrane ATP-dependent zinc metallopeptidase]]
|
could be indirect
|

|

|-
|
Protein
|
hflC 
|

|
PMID:15690043
|
Experiment(s):EBI-894532 
|-
|
Protein
|
nfi 
|

|
PMID:15690043
|
Experiment(s):EBI-894532 
|-
|
Protein
|
rplD 
|

|
PMID:15690043
|
Experiment(s):EBI-894532 
|-
|
Protein
|
rplL 
|

|
PMID:15690043
|
Experiment(s):EBI-894532 
|-
|
Protein
|
rplU 
|

|
PMID:15690043
|
Experiment(s):EBI-894532 
|-
|
Protein
|
rpsG 
|

|
PMID:15690043
|
Experiment(s):EBI-894532 
|-
|
Protein
|
[[rplU:Gene_Product(s)|rplU]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[nfi:Gene_Product(s)|nfi]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[rplD:Gene_Product(s)|rplD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[hflC:Gene_Product(s)|hflC]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[rplL:Gene_Product(s)|rplL]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6

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</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="J46aad66a31f1a" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 2 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
plasma membrane
|

|

|

|

|-
|
Inner Membrane
|

|
PMID:8444797, PMID:1925026, PMID:8106505, PMID:7781608
|
[http://www.york.ac.uk/res/thomas/Echolocation.cfm?EB_SubLocID=EB1469 EchoLocation:ftsH]
|

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<protect></protect>

===Notes===
There is an estimated 400 mc/cell<ref name='PMID:8444797'/>

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="C46aad66bca3a6" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11506-MONOMER at EcoCyc]
<pre>MAKNLILWLV IAVVLMSVFQ SFGPSESNGR KVDYSTFLQE VNNDQVREAR INGREINVTK
KDSNRYTTYI PVQDPKLLDN LLTKNVKVVG EPPEEPSLLA SIFISWFPML LLIGVWIFFM
RQMQGGGGKG AMSFGKSKAR MLTEDQIKTT FADVAGCDEA KEEVAELVEY LREPSRFQKL
GGKIPKGVLM VGPPGTGKTL LAKAIAGEAK VPFFTISGSD FVEMFVGVGA SRVRDMFEQA
KKAAPCIIFI DEIDAVGRQR GAGLGGGHDE REQTLNQMLV EMDGFEGNEG IIVIAATNRP
DVLDPALLRP GRFDRQVVVG LPDVRGREQI LKVHMRRVPL APDIDAAIIA RGTPGFSGAD
LANLVNEAAL FAARGNKRVV SMVEFEKAKD KIMMGAERRS MVMTEAQKES TAYHEAGHAI
IGRLVPEHDP VHKVTIIPRG RALGVTFFLP EGDAISASRQ KLESQISTLY GGRLAEEIIY
GPEHVSTGAS NDIKVATNLA RNMVTQWGFS EKLGPLLYAE EEGEVFLGRS VAKAKHMSDE
TARIIDQEVK ALIERNYNRA RQLLTDNMDI LHAMKDALMK YETIDAPQID DLMARRDVRP
PAGWEEPGAS NNSGDNGSPK APRPVDEPRT PNPGNTMSEQ LGDK</pre>
|-
!align=left {{table heading style}} |Length
||
644
|-
!align=left {{table heading style}} |Mol. Wt
||
70.708 kDa
|-
!align=left {{table heading style}} |pI
||
6.2 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
42,400 - 42,650 (calc based on 10 Y, 5 W, and 2 C residues)

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|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="H46aad66c48335" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
188..321
|
[http://pfam.janelia.org/family/PF00004 PF00004 ATPase family associated with various cellular activities (AAA)]
|

|
PMID:19920124
|-
|
Domain
|
381..592
|
[http://pfam.janelia.org/family/PF01434 PF01434 Peptidase family M41]
|

|
PMID:19920124
|-
|
Domain
|
5..93
|
[http://pfam.janelia.org/family/PF06480 PF06480 FtsH Extracellular]
|

|
PMID:19920124

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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|hflB}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="Q46aad66ca85b2" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsH
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0AAI3 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.26790.Q46aad66ca85b2&page=26790&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="B46aad66d94ffe" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
from rabbit
|
PMID:8444797

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.26790.B46aad66d94ffe&page=26790&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="E46aad66e01df4" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16131068 GI:16131068]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_417645.1 GeneID:947690]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0010444&formSubmitReturn=1 ASAP:ABE-0010444]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0AAI3 UniProtKB/Swiss-Prot:P0AAI3]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11506 ECOCYC:EG11506]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG11506 EcoGene:EG11506]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=947690 GeneID:947690]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.26790.E46aad66e01df4&page=26790&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="O46a869b377998" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.26790.O46a869b377998&page=26790&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

ftsH:Gene

2011-11-23T17:05:52Z

Whitley: Table edited by Whitley via TableEdit

ftsH:Expression

2011-11-23T17:02:59Z

Whitley: /* Notes */

sulA:Gene Product(s)

2011-11-23T16:29:24Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|sulA}}{{Tab|Gene|sulA}}{{Tab On|Gene Product(s)|sulA}}{{Tab|Expression|sulA}}{{Tab|Evolution|sulA}}{{Tab|On One Page|sulA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa4e4fd3837" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SulA
|-
!align=left {{table heading style}} |Synonyms
||
''SOS cell division inhibitor<ref name='LIB:Riley_2006'/>, B0958<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Suf<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfiA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SulA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0949, JW0941, sfiA, b0958''
|-
!align=left {{table heading style}} |Product description
||
suppressor of lon; inhibits cell division and ftsZ ring formation<ref name='LIB:EcoCyc10.6'/>; SOS cell division inhibitor<ref name='LIB:EcoCyc11.1'/>

Inhibits cell division and ftsZ ring formation; lexA regulon<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.B46aa4e4fd3837&page=21787&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="K46aa4e50d3b8a" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0717
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0032466
|
negative regulation of cytokinesis
|
PMID:6087326
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsZ
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006281
|
DNA repair
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0234
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006974
|
response to DNA damage stimulus
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01179
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006974
|
response to DNA damage stimulus
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0227
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009276
|
Gram-negative-bacterium-type cell wall
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004596
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009432
|
SOS response
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01179
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009432
|
SOS response
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004596
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009432
|
SOS response
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0742
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051782
|
negative regulation of cell division
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01179
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051782
|
negative regulation of cell division
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004596
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009432
|
SOS response
|
PMID:6998947
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051782
|
negative regulation of cell division
|
PMID:6998947
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0006974
|
response to DNA damage stimulus
|
PMID:11967071
|
IEP: Inferred from Expression Pattern
|

|
P
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|
EcoliWiki: ftsZ
|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.K46aa4e50d3b8a&page=21787&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="L46aa4e5f34c99" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ full length
|
FtsZ and SulA interact directly causing SulA to block cell division
|
PMID:8752322

|
2 hybrid screen
|-
|
Protein
|
FtsZ2
|

|
PMID:8752322
|
2 hybrid screen
|-
|
Protein
|
FtsZ ring
|
sulA blocks formation of FtsZ ring and leads to filamentation
|
PMID:8432706
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.L46aa4e5f34c99&page=21787&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===
FtsZ contains a fairly strong activation domain (AD) and cannot be used as the bait in 2 hybrid screens.<ref name='PMID:8752322'/>

==Localization==

{{Product_localization_help}}
{| id="B46a7e07435edb" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.B46a7e07435edb&page=21787&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="K46aa4e60edf32" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10984-MONOMER at EcoCyc]
<pre>MYTSGYAHRS SSFSSAASKI ARVSTENTTA GLISEVVYRE DQPMMTQLLL LPLLQQLGQQ
SRWQLWLTPQ QKLSREWVQA SGLPLTKVMQ ISQLSPCHTV ESMVRALRTG NYSVVIGWLA
DDLTEEEHAE LVDAANEGNA MGFIMRPVSA SSHATRQLSG LKIHSNLYH</pre>
|-
!align=left {{table heading style}} |Length
||
169
|-
!align=left {{table heading style}} |Mol. Wt
||
18.8 kDa
|-
!align=left {{table heading style}} |pI
||
7.1 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
29,450 - 29,575 (calc based on 5 Y, 4 W, and 1 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.K46aa4e60edf32&page=21787&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="S46aa4e61562a3" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
2..120
|
[http://pfam.janelia.org/family/PF03846 PF03846 Cell division inhibitor SulA]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.S46aa4e61562a3&page=21787&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="W46a7e075c802d" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=sulA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0AFZ5 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.W46a7e075c802d&page=21787&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="X46aa4e61f0572" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.X46aa4e61f0572&page=21787&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa4e6248bda" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128925 GI:16128925]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415478.1 GeneID:947335]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003244&formSubmitReturn=1 ASAP:ABE-0003244]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0AFZ5 UniProtKB/Swiss-Prot:P0AFZ5]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10984 ECOCYC:EG10984]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG10984 EcoGene:EG10984]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=947335 GeneID:947335]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.R46aa4e6248bda&page=21787&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="S46a7e0795cccc" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21787.S46a7e0795cccc&page=21787&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

zipA:Gene Product(s)

2011-11-21T19:12:18Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|zipA}}{{Tab|Gene|zipA}}{{Tab On|Gene Product(s)|zipA}}{{Tab|Expression|zipA}}{{Tab|Evolution|zipA}}{{Tab|On One Page|zipA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="J46aaa61b42d84" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
ZipA
|-
!align=left {{table heading style}} |Synonyms
||
''cell division protein involved in Z ring assembly<ref name='LIB:Riley_2006'/>, B2412<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ZipA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2407, JW2404, b2412''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein ZipA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
Septal ring structural protein for cell division and growth; anchors and stabilizes FtsZ ring<ref name='LIB:EcoGene'/><ref name='PMID:9008158'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.J46aaa61b42d84&page=25052&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="F46aaa61c4e7e3" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000910
|
cytokinesis
|
PMID:9008158
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00509
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007449
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011919
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0717
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007449
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00509
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
PMID:9008158
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011919
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009276
|
Gram-negative-bacterium-type cell wall
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007449
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0009276
|
Gram-negative-bacterium-type cell wall
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011919
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IPI: Inferred from Physical Interaction
|

|
F
|

|
Missing: with/from
|-
|

|
GO:0032155
|
cell division site part
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.F46aaa61c4e7e3&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="G46aaa61f50cb1" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|
Overexpression of FtsZ counteracts the blocked cell division that occurs when there is an overexpression of ZipA
|
PMID:9008158
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.G46aaa61f50cb1&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="H46aaa620165b4" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
Inner membrane
|

|
PMID:9008158
|
[http://www.york.ac.uk/res/thomas/Echolocation.cfm?EB_SubLocID=EB3921 EchoLocation:zipA]
|
Membrane associated
|-
|
plasma membrane
|

|

|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.H46aaa620165b4&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="X46aaa621a722c" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G7258-MONOMER at EcoCyc]
<pre>MMQDLRLILI IVGAIAIIAL LVHGFWTSRK ERSSMFRDRP LKRMKSKRDD DSYDEDVEDD
EGVGEVRVHR VNHAPANAQE HEAARPSPQH QYQPPYASAQ PRQPVQQPPE AQVPPQHAPH
PAQPVQQPAY QPQPEQPLQQ PVSPQVAPAP QPVHSAPQPA QQAFQPAEPV AAPQPEPVAE
PAPVMDKPKR KEAVIIMNVA AHHGSELNGE LLLNSIQQAG FIFGDMNIYH RHLSPDGSGP
ALFSLANMVK PGTFDPEMKD FTTPGVTIFM QVPSYGDELQ NFKLMLQSAQ HIADEVGGVV
LDDQRRMMTP QKLREYQDII REVKDANA</pre>
|-
!align=left {{table heading style}} |Length
||
328
|-
!align=left {{table heading style}} |Mol. Wt
||
36.474 kDa
|-
!align=left {{table heading style}} |pI
||
6.0 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
15,930 (calc based on 7 Y, 1 W, and C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.X46aaa621a722c&page=25052&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="C46aaa622213e4" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
191..320
|
[http://pfam.janelia.org/family/PF04354 PF04354 ZipA, C-terminal FtsZ-binding domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.C46aaa622213e4&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="Z46aaa6227e44d" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=zipA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P77173 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.Z46aaa6227e44d&page=25052&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="N46aaa626199b3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.N46aaa626199b3&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="M46aaa62677340" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16130338 GI:16130338]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_416907.1 GeneID:946869]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0007942&formSubmitReturn=1 ASAP:ABE-0007942]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P77173 UniProtKB/Swiss-Prot:P77173]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7258 ECOCYC:G7258]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG14169 EcoGene:EG14169]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=946869 GeneID:946869]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.M46aaa62677340&page=25052&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Q46a83e8eb2374" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.Q46a83e8eb2374&page=25052&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

zipA:Quickview

2011-11-21T19:12:15Z

Whitley: Updating New_Quickview_Table table.

zipA:Gene Product(s)

2011-11-21T15:46:49Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|zipA}}{{Tab|Gene|zipA}}{{Tab On|Gene Product(s)|zipA}}{{Tab|Expression|zipA}}{{Tab|Evolution|zipA}}{{Tab|On One Page|zipA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="J46aaa61b42d84" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
ZipA
|-
!align=left {{table heading style}} |Synonyms
||
''cell division protein involved in Z ring assembly<ref name='LIB:Riley_2006'/>, B2412<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ZipA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2407, JW2404, b2412''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein ZipA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Septal ring structural protein for cell division and growth; anchors and stabilizes FtsZ ring<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.J46aaa61b42d84&page=25052&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="F46aaa61c4e7e3" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000910
|
cytokinesis
|
PMID:9008158
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00509
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007449
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011919
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0717
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007449
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00509
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
PMID:9008158
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011919
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009276
|
Gram-negative-bacterium-type cell wall
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007449
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0009276
|
Gram-negative-bacterium-type cell wall
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011919
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IPI: Inferred from Physical Interaction
|

|
F
|

|
Missing: with/from
|-
|

|
GO:0032155
|
cell division site part
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.F46aaa61c4e7e3&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="G46aaa61f50cb1" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|
Overexpression of FtsZ counteracts the blocked cell division that occurs when there is an overexpression of ZipA
|
PMID:9008158
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.G46aaa61f50cb1&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="H46aaa620165b4" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
Inner membrane
|

|
PMID:9008158
|
[http://www.york.ac.uk/res/thomas/Echolocation.cfm?EB_SubLocID=EB3921 EchoLocation:zipA]
|
Membrane associated
|-
|
plasma membrane
|

|

|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.H46aaa620165b4&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="X46aaa621a722c" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G7258-MONOMER at EcoCyc]
<pre>MMQDLRLILI IVGAIAIIAL LVHGFWTSRK ERSSMFRDRP LKRMKSKRDD DSYDEDVEDD
EGVGEVRVHR VNHAPANAQE HEAARPSPQH QYQPPYASAQ PRQPVQQPPE AQVPPQHAPH
PAQPVQQPAY QPQPEQPLQQ PVSPQVAPAP QPVHSAPQPA QQAFQPAEPV AAPQPEPVAE
PAPVMDKPKR KEAVIIMNVA AHHGSELNGE LLLNSIQQAG FIFGDMNIYH RHLSPDGSGP
ALFSLANMVK PGTFDPEMKD FTTPGVTIFM QVPSYGDELQ NFKLMLQSAQ HIADEVGGVV
LDDQRRMMTP QKLREYQDII REVKDANA</pre>
|-
!align=left {{table heading style}} |Length
||
328
|-
!align=left {{table heading style}} |Mol. Wt
||
36.474 kDa
|-
!align=left {{table heading style}} |pI
||
6.0 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
15,930 (calc based on 7 Y, 1 W, and C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="C46aaa622213e4" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
191..320
|
[http://pfam.janelia.org/family/PF04354 PF04354 ZipA, C-terminal FtsZ-binding domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="Z46aaa6227e44d" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=zipA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P77173 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="N46aaa626199b3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.N46aaa626199b3&page=25052&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="M46aaa62677340" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16130338 GI:16130338]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_416907.1 GeneID:946869]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0007942&formSubmitReturn=1 ASAP:ABE-0007942]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P77173 UniProtKB/Swiss-Prot:P77173]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7258 ECOCYC:G7258]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG14169 EcoGene:EG14169]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=946869 GeneID:946869]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Q46a83e8eb2374" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25052.Q46a83e8eb2374&page=25052&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

zipA:Expression

2011-11-21T15:43:48Z

Whitley: /* Notes */

ftsE:Gene Product(s)

2011-11-17T20:32:18Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsE}}{{Tab|Gene|ftsE}}{{Tab On|Gene Product(s)|ftsE}}{{Tab|Expression|ftsE}}{{Tab|Evolution|ftsE}}{{Tab|On One Page|ftsE}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="N46aaec2271131" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsE
|-
!align=left {{table heading style}} |Synonyms
||
''predicted transporter subunit: ATP-binding component of ABC superfamily<ref name='LIB:Riley_2006'/>, B3463<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3447, JW3428, b3463''
|-
!align=left {{table heading style}} |Product description
||
cell division protein FtsE<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:FtsE/FtsX ABC transporter|FtsE/FtsX ABC transporter]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

ATP-binding protein associated with the inner membrane via FtsX; cell division, null mutant has filamentous growth and requires high salt for viability<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="V46aaec23ebff5" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003593
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:10048040
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
PMID:10048040
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003439
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000300
|
peripheral to membrane of membrane fraction
|
PMID:10048040
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005286
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:10048040
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsX|EcoliWiki:ftsE
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:4583216
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR013505
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
PMID:10048040
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0046677
|
response to antibiotic
|
PMID:4583216
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR017871
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9658012
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000910
|
cytokinesis
|
PMID:9658012
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsZ
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003439
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032155
|
cell division site part
|
PMID:14729705
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR017871
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0017111
|
nucleoside-triphosphatase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003593
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="G46aaec2c25197" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:FtsE/FtsX ABC transporter|FtsE/FtsX ABC transporter]]
|
could be indirect
|

|

|-
|
Protein
|
groL 
|

|
PMID:16606699
|
Experiment(s):EBI-1145961 
|-
|
Protein
|
rsmD 
|

|
PMID:16606699
|
Experiment(s):EBI-1145961 
|-
|
Protein
|
hchA 
|

|
PMID:16606699
|
Experiment(s):EBI-1145961 
|-
|
Protein
|
prs 
|

|
PMID:16606699
|
Experiment(s):EBI-1145961 
|-
|
Protein
|
slyD 
|

|
PMID:16606699
|
Experiment(s):EBI-1145961 
|-
|
Protein
|
groL 
|

|
PMID:15690043
|
Experiment(s):EBI-881078, EBI-888030 
|-
|
Protein
|
hldD 
|

|
PMID:15690043
|
Experiment(s):EBI-881078 
|-
|
Protein
|
rpsB 
|

|
PMID:15690043
|
Experiment(s):EBI-881078 
|-
|
Protein
|
tufA 
|

|
PMID:15690043
|
Experiment(s):EBI-881078 
|-
|
Protein
|
ynaA 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
yfjV 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
cdd 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
ibpA 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rplB 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rplP 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rplR 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rplU 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rplV 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rpmC 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rpsE 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rpsG 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rpsI 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rpsJ 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rpsP 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
sbcC 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
ushA 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
rplK 
|

|
PMID:15690043
|
Experiment(s):EBI-888030 
|-
|
Protein
|
[[groL:Gene_Product(s)|groL]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6 MALDI(Z-score):17.053160
|-
|
Protein
|
[[ibpA:Gene_Product(s)|ibpA]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
[[groS:Gene_Product(s)|groS]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160
|-
|
Protein
|
[[murC:Gene_Product(s)|murC]]
|

|
PMID:19402753
|
MALDI(Z-score):28.655358
|-
|
Protein
|
[[sbcC:Gene_Product(s)|sbcC]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
[[ushA:Gene_Product(s)|ushA]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
[[cdd:Gene_Product(s)|cdd]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
[[murB:Gene_Product(s)|murB]]
|

|
PMID:19402753
|
MALDI(Z-score):37.523561
|-
|
Protein
|
FtsZ
|
interacts directly and is independent of FtsX
|
PMID:17307852
|

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="X46aaec2d6ac79" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="E46aaec2f1e59f" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=FTSE-MONOMER at EcoCyc]
<pre>MIRFEHVSKA YLGGRQALQG VTFHMQPGEM AFLTGHSGAG KSTLLKLICG IERPSAGKIW
FSGHDITRLK NREVPFLRRQ IGMIFQDHHL LMDRTVYDNV AIPLIIAGAS GDDIRRRVSA
ALDKVGLLDK AKNFPIQLSG GEQQRVGIAR AVVNKPAVLL ADEPTGNLDD ALSEGILRLF
EEFNRVGVTV LMATHDINLI SRRSYRMLTL SDGHLHGGVG HE</pre>
|-
!align=left {{table heading style}} |Length
||
222
|-
!align=left {{table heading style}} |Mol. Wt
||
24.439 kDa
|-
!align=left {{table heading style}} |pI
||
9.7 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,095 (calc based on 3 Y, 1 W, and 1 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="L46aaec2f94d17" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
42..166
|
[http://pfam.janelia.org/family/PF00005 PF00005 ABC transporter]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="W46a87b7031986" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsE
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0A9R7 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27434.W46a87b7031986&page=27434&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="W46aaec306b2a3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27434.W46aaec306b2a3&page=27434&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46aaec30d0e2e" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16131335 GI:16131335]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_417920.1 GeneID:947968]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0011313&formSubmitReturn=1 ASAP:ABE-0011313]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0A9R7 UniProtKB/Swiss-Prot:P0A9R7]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10340 ECOCYC:EG10340]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG10340 EcoGene:EG10340]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=947968 GeneID:947968]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27434.G46aaec30d0e2e&page=27434&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="C46a87b73b3ca0" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27434.C46a87b73b3ca0&page=27434&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsE:Gene

2011-11-17T20:16:29Z

Whitley: Table edited by Whitley via TableEdit

ftsK:Gene

2011-11-17T18:48:31Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab On|Gene|ftsK}}{{Tab|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Interactions | Genetic Interactions]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="D46a9bb0157a6c" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''ftsK''
|-
!align=left {{table_heading_style}} |Mnemonic
||
filamentation temperature sensitive
Filamentation, temperature sensitive
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>, dinH'',
usoM <ref name='PMID:9294449'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.D46a9bb0157a6c&page=12339&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="V46a9bb01cfcb0" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
20.1 minutes 
|
MG1655: 932447..936436 <gbrowseImage>
name=NC_000913:932447..936436
source=MG1655
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=G6464 EcoCyc]
{{GBrowseLink|MG1655|NC_000913|931447|937436|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|MG1655|NC_000913|932447|936436|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=G6464 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 950282..954310 <gbrowseImage>
name=NC_012967:950282..954310
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|950282|954310|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|950282|954310|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 835415..839404 <gbrowseImage>
name=NC_012759:835415..839404
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|NC_012759|835415|839404|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|NC_012759|835415|839404|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 933646..937635 <gbrowseImage>
name=AC_000091:933646..937635
source=W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|W3110|AC_000091|932646|938635|GBrowse(W3110)}}
|
{{GBrowseFastaLink|W3110|AC_000091|933646|937635|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 986375..990364 <gbrowseImage>
name=NC_010473:986375..990364
source=DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|DH10B|NC_010473|978397|998342|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|DH10B|NC_010473|978397|998342|FASTA Dump}}

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.V46a9bb01cfcb0&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="U46a9bb0279a81" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.U46a9bb0279a81&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="B46a9bb02b9f16" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔLC
|

|

|

|

|
PMID:15522074
|

|
Carries a deletion of FtsK L and FtsK C
|-
|
''ftsK''G80A
|

|
G80A
|

|
In Toe44; loss of function under extreme conditions
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
ftsKE58A
|

|
E58A
|

|
Loss of function
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
NC
|

|

|

|

|
PMID:15522074
|
Barre
|
Deletion of the FtsK Linker
|-
|
NL hi C
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H. influenzae'' FtsK regions
|-
|
ftsK A
|

|
K997A
|

|

|
PMID:15522074
|
Barre
|
Carries a single point mutation in the walker A motif of FtsK C
|-
|
NLC hi
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H.influenzae'' FtsK regions
|-
|
ftsk::cat1
|

|

|

|

|
PMID:9721304
|
Donachie
Sheratt

|
only expresses the NTD due to a Cm resistance cassette at nt 678 of ''ftsK''
|-
|
''ftsk44''
|
missense mutation
|
G80A
|
Growth Phenotype
|
temperature sensitive late stage block in division, but does not affect chromosome replication or segregation

forms long filamentous cells at 42C

|
PMID:7592387

PMID:9721304
|
Donachie
|
this is the allele from the TOE44 strain listed in this table.
|-
|
''ftsK1::cat''
|

|

|

|
abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation
|
* PMID:9294448
* PMID:9829960
|

|
defect in the C-terminus of FtsK
|-
|
''ftsK1::cat ΔmukB''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:9829960
|

|
shown that it must be complemented in trans
|-
|
''ftsK::cat-2''
|
Δ54-2201
|

|

|

|
PMID:9721304
|

|
almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the ''cat'' gene. Lethal- must be complemented ''in trans''
|-
|
''ftsK::cat-Δ5''
|
Δ54-3651
|

|

|

|
PMID:9721304
|

|
this is a deletion of 90% of ''ftsK''
|-
|
''ftsK3531''
|
missense mutation
|

|
Growth Phenotype
|
same phenotype as ''ftsK44''- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:9721304
|

|
suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the ''dacA'' gene, encoding PBP5.
|-
|
''ftsK::cat-Δ2 ΔdacA::kan''
|

|

|
Cell Shape
|
*forms small colonies on plates grows well
*produces a population of misshapen cells in liquid culture
|
PMID:9721304
|

|

|-
|
''ftsK::cat-Δ5 Δdac::kan''
|

|

|

|
synthetically lethal
|
PMID:9721304
|

|

|-
|
''ftsKC priA2::kan''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:11459954

|

|

|-
|
''ftsK1::cat ΔminB''
|

|

|
Growth Phenotype
|
chains of minicells generated (many of which contained DNA)
|
PMID:9829960
|

|

|-
|
''ftsK100''
|

|
K997A
|

|
ATP mutant
|
PMID:18363794
|

|

|-
|
ftsK10
|

|

|
Growth Phenotype
|
affects expression form the uspA promoter, results in salt sensitivity, stationary-phase survival is impaired, and cell-cell separation is blocked
|
PMID:9294449
|

|
Also called usoM10

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.B46a9bb02b9f16&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_allele_table edit table] || || || || || || ||
|}


<protect></protect>
===Notes===
Deletions that leave the membrane segments intact are viable<ref name='PMID: 9721304'/>. Suppressors of the ''ftsK'' chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.

==Genetic Interactions==
{{BacktoTop}}
<protect>
{{Genetic_interaction_help}}
{| id="X4e04bb9e6c34f" class=" tableEdit Genetic_interaction_table dataTable"
|- {{table_heading_style}}
!|Interactor!!Interaction!!Allele!!Score(s)!!Reference(s)!!Accessions!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.12339.X4e04bb9e6c34f&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Genetic_interaction_table edit table] || || || || || ||
|}
</protect>


===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="R46a9bb0364216" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW0873
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG
|-
|
[[:Category:Kohara_Phage:1F10|1F10]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=214 Genobase]
|
PMID:3038334
|-
|
[[:Category:Kohara_Phage:E6H3|E6H3]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=215 Genobase]
|
PMID:3038334
|-
|
zbh-29::Tn10
|
Linked marker
|
CAG18493 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39400 CGSC7353]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: % <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbi-29::Tn10
|-
|
zca-1230::Tn10
|
Linked marker
|
CAG18478 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39407 CGSC7356]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 61% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbj-1230::Tn10
|-
|
W3110::P''lac-ftsK''
|
Strain
|

|
Depletion Strain<ref name='PMID:9723913'/>
|-
|
pWL71
|
Plasmid Clone
|
Pbad-FtsK(1-202)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain<ref name='PMID:9723913'/>
|-
|
pWL72
|
Plasmid Clone
|
Pbad-FtsK(1-211)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL73
|
Plasmid Clone
|
Pbad-FtsK(1-251)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL74
|
Plasmid Clone
|
Pbad-FtsK(1-644)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL75
|
Plasmid Clone
|
Pbad-FtsK(1-1329)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL76
|
Plasmid Clone
|
Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK
|
Cannot complement the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pFtsK-PhoA plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''phoA'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFtsK-LacZ plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''lacZ'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFLAG-FtsK plasmids
|
Plasmid Clone
|

|
This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG<ref name='PMID:11114887'/>.
|-
|
MA3
|
Strain
|
AB1157''ftsK''
|
PMID:10523315
|-
|
GR51
|
Strain
|
AB1157''xerCftsK''
|
PMID:10523315
|-
|
GR59
|
Strain
|
AB1157''ftsK recA56 srl::Tn10''
|
PMID:10523315
|-
|
FC1
|
Strain
|
AB1157, ''ftsK100'' K997A (ATP mutant), CmR
|
PMID:18363794
|-
|
FtsK-YFP
|
Plasmid Clone
|
*low-copy expression vectors derived from pSC101
*Spectinomycin resistance gene
|
PMID:18363794
|-
|
FtsKΔγ
|
Plasmid Clone
|
FtsK50C deleted from residue 1248
|
PMID:19854947

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.R46a9bb0364216&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_resource_table edit table] || || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46a9bb03edc16" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI] ([[NCBI|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.G46a9bb03edc16&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Y46a6d85840482" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.Y46a6d85840482&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude><protect>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Genes not in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:fts genes]][[Category:Gene_List:DH10B]][[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]

ftsK:Gene Product(s)

2011-11-17T18:44:36Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab|Gene|ftsK}}{{Tab On|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="R46aa4982a88b9" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsK
|-
!align=left {{table heading style}} |Synonyms
||
''DNA-binding membrane protein required for chromosome resolution and partitioning<ref name='LIB:Riley_2006'/>, B0890<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DinH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dinH, ECK0881, JW0873, b0890''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsK <ref name='PMID:9723913'/><ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]<ref name='LIB:EcoCyc11.1'/>

DNA translocase at septal ring sorting daughter chromsomes<ref name='LIB:EcoGene'/>

|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="S46aa49840dbe9" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051301
|
cell division
|
PMID:9721304
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:7592387
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:17805344
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in ''parC(ts)'' and ''parE(ts)'' cells
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:10922461
|
EXP: Inferred from Experiment
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0159
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minC EcoliWiki:minD EcoliWiki:minE
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:16301526
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17041598
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17057717
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:9723913
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0071236
|
cellular response to antibiotic
|
PMID:9723913
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
mitomycin C
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:xerC
EcoliWiki:xerD

|
P
|

|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
increases P''uspA'' activity in stationary phase
|
complete
|-
|
Contributes to
|
GO:0006265
|

|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|

|
stimulates Topo IV's ability to relax positively supercoiled DNA
|
complete
|-
|

|
GO:0009651
|
response to salt stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|
Contributes to
|
GO:0007059
|
chromosome segregation
|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|
P
|
stimulates Topo IV's decatenation ability
|
complete
|-
|

|
GO:0000920
|
cytokinetic cell separation
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki: minC | EcoliWiki: minD | EcoliWiki: minE
|
P
|

|
complete

|- class="tableEdit_footer"
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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aa498d2fdf4" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]
|
could be indirect
|

|

|-
|
Protein
|
aceE 
|

|
PMID:15690043
|
Experiment(s):EBI-888719 
|-
|
Protein
|
[[rpsJ:Gene_Product(s)|rpsJ]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[yfiD:Gene_Product(s)|yfiD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
ParC subunit of Topo IV
|
PMID: 12939258
|

|

|-
|
Protein
|
Either subunit of the XerCD Recombinase
|

|
PMID:19854947
|
Triplex Displacement Assays

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| {{Prettytable}} id="M46aa498e3f43d" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
Inner membrane
|
GFP fusion localization
|
PMID:9495771
|
Signal sequence in the N-terminal domain of the protein
|

|-
|
Inner membrane
|
PhoA and beta-gal assays
|
PMID:10922461
|

|

|-
|
Cytosol
|
FtsK (818-1329)
|
Microscopy
|
PMID:11114887
|

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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa498fab9bb" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6464-MONOMER at EcoCyc]
<pre>MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD</pre>
|-
!align=left {{table heading style}} |Length
||
1,329
|-
!align=left {{table heading style}} |Mol. Wt
||
146.661 kDa
|-
!align=left {{table heading style}} |pI
||
4.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

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<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa4990131be" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
947..1161
|
[http://pfam.janelia.org/family/PF01580 PF01580 FtsK/SpoIIIE family]
|

|
PMID:19920124
|-
|
Domain
|
1261..1327
|
[http://pfam.janelia.org/family/PF09397 PF09397 Ftsk gamma domain]
|

|
PMID:19920124

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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsK}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="S46a7db57eacb5" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsK
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P46889 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
* Membrane topology studies using ''phoA'' and ''lacZ'' fusions are described in Dorazi ''et al.''(2000)<ref name='PMID:10922461'/>

* Crystal structure of ''P. aeruginosa'' FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe ''et al.'' (2008)<ref name='PMID:18722176'/>.

*FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation<ref name='PMID:17511809'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa4990ac348" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
raised against FtsK(447-729)
|
isolated from rabbit <ref name='PMID:9723913'/>
|-
|
Purification protocol
|

|
*PMID:18722176
*PMID:20081205
*PMID:12939258
*PMID:11832210

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<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa499104897" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128857 GI:16128857]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415410.1 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003027&formSubmitReturn=1 ASAP:ABE-0003027]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P46889 UniProtKB/Swiss-Prot:P46889]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

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<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="R46a7db5b75b2f" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsK:Quickview

2011-11-17T18:44:33Z

Whitley: Updating New_Quickview_Table table.

ftsK:Gene Product(s)

2011-11-17T18:44:09Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab|Gene|ftsK}}{{Tab On|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="R46aa4982a88b9" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsK
|-
!align=left {{table heading style}} |Synonyms
||
''DNA-binding membrane protein required for chromosome resolution and partitioning<ref name='LIB:Riley_2006'/>, B0890<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DinH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , dinH, ECK0881, JW0873, b0890''
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsK <ref name='PMID:9723913'/><ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]<ref name='LIB:EcoCyc11.1'/>

DNA translocase at septal ring sorting daughter chromsomes<ref name='LIB:EcoGene'/>

Causes a late-stage block in division that is temperature sensitive <ref name='pmid:7592387'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="S46aa49840dbe9" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051301
|
cell division
|
PMID:9721304
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:7592387
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:17805344
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in ''parC(ts)'' and ''parE(ts)'' cells
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
PMID:10922461
|
EXP: Inferred from Experiment
|

|
C
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005887
|
integral to plasma membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:18722176
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR002543
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0159
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minC EcoliWiki:minD EcoliWiki:minE
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:16301526
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17041598
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043565
|
sequence-specific DNA binding
|
PMID:17057717
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:9723913
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0016020
|
membrane
|
PMID:10922461
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0071236
|
cellular response to antibiotic
|
PMID:9723913
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
mitomycin C
|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0015616
|
DNA translocase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:9829960
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:19854947
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:xerC
EcoliWiki:xerD

|
P
|

|
complete
|-
|

|
GO:0045941
|
positive regulation of transcription
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
increases P''uspA'' activity in stationary phase
|
complete
|-
|
Contributes to
|
GO:0006265
|

|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|

|
stimulates Topo IV's ability to relax positively supercoiled DNA
|
complete
|-
|

|
GO:0009651
|
response to salt stress
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|
Contributes to
|
GO:0007059
|
chromosome segregation
|
PMID:20081205
|
IDA: Inferred from Direct Assay
|

|
P
|
stimulates Topo IV's decatenation ability
|
complete
|-
|

|
GO:0000920
|
cytokinetic cell separation
|
PMID:9294448
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0007059
|
chromosome segregation
|
PMID:12034757
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki: minC | EcoliWiki: minD | EcoliWiki: minE
|
P
|

|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aa498d2fdf4" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:Xer site-specific recombination system|Xer site-specific recombination system]]
|
could be indirect
|

|

|-
|
Protein
|
aceE 
|

|
PMID:15690043
|
Experiment(s):EBI-888719 
|-
|
Protein
|
[[rpsJ:Gene_Product(s)|rpsJ]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
[[yfiD:Gene_Product(s)|yfiD]]
|

|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
ParC subunit of Topo IV
|
PMID: 12939258
|

|

|-
|
Protein
|
Either subunit of the XerCD Recombinase
|

|
PMID:19854947
|
Triplex Displacement Assays

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</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| {{Prettytable}} id="M46aa498e3f43d" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 6 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|-
|
Inner membrane
|
GFP fusion localization
|
PMID:9495771
|
Signal sequence in the N-terminal domain of the protein
|

|-
|
Inner membrane
|
PhoA and beta-gal assays
|
PMID:10922461
|

|

|-
|
Cytosol
|
FtsK (818-1329)
|
Microscopy
|
PMID:11114887
|

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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aa498fab9bb" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6464-MONOMER at EcoCyc]
<pre>MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD</pre>
|-
!align=left {{table heading style}} |Length
||
1,329
|-
!align=left {{table heading style}} |Mol. Wt
||
146.661 kDa
|-
!align=left {{table heading style}} |pI
||
4.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

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|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa4990131be" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
947..1161
|
[http://pfam.janelia.org/family/PF01580 PF01580 FtsK/SpoIIIE family]
|

|
PMID:19920124
|-
|
Domain
|
1261..1327
|
[http://pfam.janelia.org/family/PF09397 PF09397 Ftsk gamma domain]
|

|
PMID:19920124

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</td>
<td>


<motif_map/>
{{TMHMM Picture|ftsK}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="S46a7db57eacb5" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsK
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P46889 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
* Membrane topology studies using ''phoA'' and ''lacZ'' fusions are described in Dorazi ''et al.''(2000)<ref name='PMID:10922461'/>

* Crystal structure of ''P. aeruginosa'' FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe ''et al.'' (2008)<ref name='PMID:18722176'/>.

*FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation<ref name='PMID:17511809'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa4990ac348" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Antibody
|
raised against FtsK(447-729)
|
isolated from rabbit <ref name='PMID:9723913'/>
|-
|
Purification protocol
|

|
*PMID:18722176
*PMID:20081205
*PMID:12939258
*PMID:11832210

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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="R46aa499104897" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128857 GI:16128857]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415410.1 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0003027&formSubmitReturn=1 ASAP:ABE-0003027]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P46889 UniProtKB/Swiss-Prot:P46889]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21613.R46aa499104897&page=21613&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="R46a7db5b75b2f" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21613.R46a7db5b75b2f&page=21613&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsK:Quickview

2011-11-17T18:44:06Z

Whitley: Updating New_Quickview_Table table.

ftsK:Quickview

2011-11-17T18:44:05Z

Whitley: Updating New_Quickview_Table table.

ftsA:Gene

2011-11-17T18:40:15Z

Whitley: Table edited by Whitley via TableEdit

ftsK:Gene

2011-11-14T19:33:29Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab On|Gene|ftsK}}{{Tab|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Interactions | Genetic Interactions]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="D46a9bb0157a6c" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''ftsK''
|-
!align=left {{table_heading_style}} |Mnemonic
||
filamentation temperature sensitive
Filamentation, temperature sensitive
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>, dinH'',
usoM <ref name='PMID:9294449'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.D46a9bb0157a6c&page=12339&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="V46a9bb01cfcb0" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
20.1 minutes 
|
MG1655: 932447..936436 <gbrowseImage>
name=NC_000913:932447..936436
source=MG1655
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=G6464 EcoCyc]
{{GBrowseLink|MG1655|NC_000913|931447|937436|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|MG1655|NC_000913|932447|936436|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=G6464 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 950282..954310 <gbrowseImage>
name=NC_012967:950282..954310
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|950282|954310|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|950282|954310|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 835415..839404 <gbrowseImage>
name=NC_012759:835415..839404
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|NC_012759|835415|839404|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|NC_012759|835415|839404|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 933646..937635 <gbrowseImage>
name=AC_000091:933646..937635
source=W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|W3110|AC_000091|932646|938635|GBrowse(W3110)}}
|
{{GBrowseFastaLink|W3110|AC_000091|933646|937635|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 986375..990364 <gbrowseImage>
name=NC_010473:986375..990364
source=DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|DH10B|NC_010473|978397|998342|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|DH10B|NC_010473|978397|998342|FASTA Dump}}

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.V46a9bb01cfcb0&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="U46a9bb0279a81" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.U46a9bb0279a81&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="B46a9bb02b9f16" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔLC
|

|

|

|

|
PMID:15522074
|

|
Carries a deletion of FtsK L and FtsK C
|-
|
''ftsK''G80A
|

|
G80A
|

|
In Toe44; loss of function under extreme conditions
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
ftsKE58A
|

|
E58A
|

|
Loss of function
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
NC
|

|

|

|

|
PMID:15522074
|
Barre
|
Deletion of the FtsK Linker
|-
|
NL hi C
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H. influenzae'' FtsK regions
|-
|
ftsK A
|

|
K997A
|

|

|
PMID:15522074
|
Barre
|
Carries a single point mutation in the walker A motif of FtsK C
|-
|
NLC hi
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H.influenzae'' FtsK regions
|-
|
ftsk::cat1
|

|

|

|

|
PMID:9721304
|
Donachie
Sheratt

|
only expresses the NTD due to a Cm resistance cassette at nt 678 of ''ftsK''
|-
|
''ftsk44''
|
missense mutation
|
G80A
|
Growth Phenotype
|
temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:7592387

PMID:9721304
|
Donachie
|
this is the allele from the TOE44 strain listed in this table.
|-
|
''ftsK1::cat''
|

|

|

|
abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation
|
* PMID:9294448
* PMID:9829960
|

|
defect in the C-terminus of FtsK
|-
|
''ftsK1::cat ΔmukB''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:9829960
|

|
shown that it must be complemented in trans
|-
|
''ftsK::cat-2''
|
Δ54-2201
|

|

|

|
PMID:9721304
|

|
almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the ''cat'' gene. Lethal- must be complemented ''in trans''
|-
|
''ftsK::cat-Δ5''
|
Δ54-3651
|

|

|

|
PMID:9721304
|

|
this is a deletion of 90% of ''ftsK''
|-
|
''ftsK3531''
|
missense mutation
|

|
Growth Phenotype
|
same phenotype as ''ftsK44''- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:9721304
|

|
suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the ''dacA'' gene, encoding PBP5.
|-
|
''ftsK::cat-Δ2 ΔdacA::kan''
|

|

|
Cell Shape
|
*forms small colonies on plates grows well
*produces a population of misshapen cells in liquid culture
|
PMID:9721304
|

|

|-
|
''ftsK::cat-Δ5 Δdac::kan''
|

|

|

|
synthetically lethal
|
PMID:9721304
|

|

|-
|
''ftsKC priA2::kan''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:11459954

|

|

|-
|
''ftsK1::cat ΔminB''
|

|

|
Growth Phenotype
|
chains of minicells generated (many of which contained DNA)
|
PMID:9829960
|

|

|-
|
''ftsK100''
|

|
K997A
|

|
ATP mutant
|
PMID:18363794
|

|

|-
|
ftsK10
|

|

|
Growth Phenotype
|
affects expression form the uspA promoter, results in salt sensitivity, stationary-phase survival is impaired, and cell-cell separation is blocked
|
PMID:9294449
|

|
Also called usoM10

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.B46a9bb02b9f16&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_allele_table edit table] || || || || || || ||
|}


<protect></protect>
===Notes===
Deletions that leave the membrane segments intact are viable<ref name='PMID: 9721304'/>. Suppressors of the ''ftsK'' chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.

==Genetic Interactions==
{{BacktoTop}}
<protect>
{{Genetic_interaction_help}}
{| id="X4e04bb9e6c34f" class=" tableEdit Genetic_interaction_table dataTable"
|- {{table_heading_style}}
!|Interactor!!Interaction!!Allele!!Score(s)!!Reference(s)!!Accessions!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.12339.X4e04bb9e6c34f&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Genetic_interaction_table edit table] || || || || || ||
|}
</protect>


===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="R46a9bb0364216" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW0873
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG
|-
|
[[:Category:Kohara_Phage:1F10|1F10]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=214 Genobase]
|
PMID:3038334
|-
|
[[:Category:Kohara_Phage:E6H3|E6H3]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=215 Genobase]
|
PMID:3038334
|-
|
zbh-29::Tn10
|
Linked marker
|
CAG18493 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39400 CGSC7353]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: % <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbi-29::Tn10
|-
|
zca-1230::Tn10
|
Linked marker
|
CAG18478 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39407 CGSC7356]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 61% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbj-1230::Tn10
|-
|
W3110::P''lac-ftsK''
|
Strain
|

|
Depletion Strain<ref name='PMID:9723913'/>
|-
|
pWL71
|
Plasmid Clone
|
Pbad-FtsK(1-202)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain<ref name='PMID:9723913'/>
|-
|
pWL72
|
Plasmid Clone
|
Pbad-FtsK(1-211)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL73
|
Plasmid Clone
|
Pbad-FtsK(1-251)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL74
|
Plasmid Clone
|
Pbad-FtsK(1-644)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL75
|
Plasmid Clone
|
Pbad-FtsK(1-1329)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL76
|
Plasmid Clone
|
Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK
|
Cannot complement the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pFtsK-PhoA plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''phoA'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFtsK-LacZ plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''lacZ'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFLAG-FtsK plasmids
|
Plasmid Clone
|

|
This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG<ref name='PMID:11114887'/>.
|-
|
MA3
|
Strain
|
AB1157''ftsK''
|
PMID:10523315
|-
|
GR51
|
Strain
|
AB1157''xerCftsK''
|
PMID:10523315
|-
|
GR59
|
Strain
|
AB1157''ftsK recA56 srl::Tn10''
|
PMID:10523315
|-
|
FC1
|
Strain
|
AB1157, ''ftsK100'' K997A (ATP mutant), CmR
|
PMID:18363794
|-
|
FtsK-YFP
|
Plasmid Clone
|
*low-copy expression vectors derived from pSC101
*Spectinomycin resistance gene
|
PMID:18363794
|-
|
FtsKΔγ
|
Plasmid Clone
|
FtsK50C deleted from residue 1248
|
PMID:19854947

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.R46a9bb0364216&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_resource_table edit table] || || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46a9bb03edc16" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI] ([[NCBI|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.G46a9bb03edc16&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Y46a6d85840482" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.Y46a6d85840482&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude><protect>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Genes not in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:fts genes]][[Category:Gene_List:DH10B]][[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]

ftsK:Gene

2011-11-14T19:30:23Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab On|Gene|ftsK}}{{Tab|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Interactions | Genetic Interactions]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="D46a9bb0157a6c" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''ftsK''
|-
!align=left {{table_heading_style}} |Mnemonic
||
filamentation temperature sensitive
Filamentation, temperature sensitive
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>, dinH'',
usoM <ref name='PMID:9294449'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.D46a9bb0157a6c&page=12339&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="V46a9bb01cfcb0" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
20.1 minutes 
|
MG1655: 932447..936436 <gbrowseImage>
name=NC_000913:932447..936436
source=MG1655
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=G6464 EcoCyc]
{{GBrowseLink|MG1655|NC_000913|931447|937436|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|MG1655|NC_000913|932447|936436|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=G6464 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 950282..954310 <gbrowseImage>
name=NC_012967:950282..954310
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|950282|954310|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|950282|954310|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 835415..839404 <gbrowseImage>
name=NC_012759:835415..839404
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|NC_012759|835415|839404|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|NC_012759|835415|839404|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 933646..937635 <gbrowseImage>
name=AC_000091:933646..937635
source=W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|W3110|AC_000091|932646|938635|GBrowse(W3110)}}
|
{{GBrowseFastaLink|W3110|AC_000091|933646|937635|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 986375..990364 <gbrowseImage>
name=NC_010473:986375..990364
source=DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|DH10B|NC_010473|978397|998342|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|DH10B|NC_010473|978397|998342|FASTA Dump}}

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.V46a9bb01cfcb0&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="U46a9bb0279a81" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.U46a9bb0279a81&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="B46a9bb02b9f16" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔLC
|

|

|

|

|
PMID:15522074
|

|
Carries a deletion of FtsK L and FtsK C
|-
|
''ftsK''G80A
|

|
G80A
|

|
In Toe44; loss of function under extreme conditions
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
ftsKE58A
|

|
E58A
|

|
Loss of function
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
NC
|

|

|

|

|
PMID:15522074
|
Barre
|
Deletion of the FtsK Linker
|-
|
NL hi C
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H. influenzae'' FtsK regions
|-
|
ftsK A
|

|
K997A
|

|

|
PMID:15522074
|
Barre
|
Carries a single point mutation in the walker A motif of FtsK C
|-
|
NLC hi
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H.influenzae'' FtsK regions
|-
|
ftsk::cat1
|

|

|

|

|
PMID:9721304
|
Donachie
Sheratt

|
only expresses the NTD due to a Cm resistance cassette at nt 678 of ''ftsK''
|-
|
''ftsk44''
|
missense mutation
|
G80A
|
Growth Phenotype
|
temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:7592387

PMID:9721304
|
Donachie
|
this is the allele from the TOE44 strain listed in this table.
|-
|
''ftsK1::cat''
|

|

|

|
abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation
|
* PMID:9294448
* PMID:9829960
|

|
defect in the C-terminus of FtsK
|-
|
''ftsK1::cat ΔmukB''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:9829960
|

|
shown that it must be complemented in trans
|-
|
''ftsK::cat-2''
|
Δ54-2201
|

|

|

|
PMID:9721304
|

|
almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the ''cat'' gene. Lethal- must be complemented ''in trans''
|-
|
''ftsK::cat-Δ5''
|
Δ54-3651
|

|

|

|
PMID:9721304
|

|
this is a deletion of 90% of ''ftsK''
|-
|
''ftsK3531''
|
missense mutation
|

|
Growth Phenotype
|
same phenotype as ''ftsK44''- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:9721304
|

|
suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the ''dacA'' gene, encoding PBP5.
|-
|
''ftsK::cat-Δ2 ΔdacA::kan''
|

|

|
Cell Shape
|
*forms small colonies on plates grows well
*produces a population of misshapen cells in liquid culture
|
PMID:9721304
|

|

|-
|
''ftsK::cat-Δ5 Δdac::kan''
|

|

|

|
synthetically lethal
|
PMID:9721304
|

|

|-
|
''ftsKC priA2::kan''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:11459954

|

|

|-
|
''ftsK1::cat ΔminB''
|

|

|
Growth Phenotype
|
chains of minicells generated (many of which contained DNA)
|
PMID:9829960
|

|

|-
|
''ftsK100''
|

|
K997A
|

|
ATP mutant
|
PMID:18363794
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.B46a9bb02b9f16&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_allele_table edit table] || || || || || || ||
|}


<protect></protect>
===Notes===
Deletions that leave the membrane segments intact are viable<ref name='PMID: 9721304'/>. Suppressors of the ''ftsK'' chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.

==Genetic Interactions==
{{BacktoTop}}
<protect>
{{Genetic_interaction_help}}
{| id="X4e04bb9e6c34f" class=" tableEdit Genetic_interaction_table dataTable"
|- {{table_heading_style}}
!|Interactor!!Interaction!!Allele!!Score(s)!!Reference(s)!!Accessions!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.12339.X4e04bb9e6c34f&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Genetic_interaction_table edit table] || || || || || ||
|}
</protect>


===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="R46a9bb0364216" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW0873
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG
|-
|
[[:Category:Kohara_Phage:1F10|1F10]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=214 Genobase]
|
PMID:3038334
|-
|
[[:Category:Kohara_Phage:E6H3|E6H3]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=215 Genobase]
|
PMID:3038334
|-
|
zbh-29::Tn10
|
Linked marker
|
CAG18493 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39400 CGSC7353]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: % <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbi-29::Tn10
|-
|
zca-1230::Tn10
|
Linked marker
|
CAG18478 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39407 CGSC7356]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 61% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbj-1230::Tn10
|-
|
W3110::P''lac-ftsK''
|
Strain
|

|
Depletion Strain<ref name='PMID:9723913'/>
|-
|
pWL71
|
Plasmid Clone
|
Pbad-FtsK(1-202)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain<ref name='PMID:9723913'/>
|-
|
pWL72
|
Plasmid Clone
|
Pbad-FtsK(1-211)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL73
|
Plasmid Clone
|
Pbad-FtsK(1-251)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL74
|
Plasmid Clone
|
Pbad-FtsK(1-644)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL75
|
Plasmid Clone
|
Pbad-FtsK(1-1329)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL76
|
Plasmid Clone
|
Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK
|
Cannot complement the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pFtsK-PhoA plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''phoA'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFtsK-LacZ plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''lacZ'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFLAG-FtsK plasmids
|
Plasmid Clone
|

|
This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG<ref name='PMID:11114887'/>.
|-
|
MA3
|
Strain
|
AB1157''ftsK''
|
PMID:10523315
|-
|
GR51
|
Strain
|
AB1157''xerCftsK''
|
PMID:10523315
|-
|
GR59
|
Strain
|
AB1157''ftsK recA56 srl::Tn10''
|
PMID:10523315
|-
|
FC1
|
Strain
|
AB1157, ''ftsK100'' K997A (ATP mutant), CmR
|
PMID:18363794
|-
|
FtsK-YFP
|
Plasmid Clone
|
*low-copy expression vectors derived from pSC101
*Spectinomycin resistance gene
|
PMID:18363794
|-
|
FtsKΔγ
|
Plasmid Clone
|
FtsK50C deleted from residue 1248
|
PMID:19854947

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.R46a9bb0364216&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_resource_table edit table] || || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46a9bb03edc16" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI] ([[NCBI|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.G46a9bb03edc16&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Y46a6d85840482" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.Y46a6d85840482&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude><protect>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Genes not in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:fts genes]][[Category:Gene_List:DH10B]][[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]

ftsK:Quickview

2011-11-14T19:30:21Z

Whitley: Updating New_Quickview_Table table.

ftsK:Gene

2011-11-14T19:30:02Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab On|Gene|ftsK}}{{Tab|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Interactions | Genetic Interactions]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="D46a9bb0157a6c" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''ftsK''
|-
!align=left {{table_heading_style}} |Mnemonic
||
filamentation temperature sensitive
Filamentation, temperature sensitive
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>, dinH''
usoM <ref name='PMID:9294449'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.D46a9bb0157a6c&page=12339&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="V46a9bb01cfcb0" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
20.1 minutes 
|
MG1655: 932447..936436 <gbrowseImage>
name=NC_000913:932447..936436
source=MG1655
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=G6464 EcoCyc]
{{GBrowseLink|MG1655|NC_000913|931447|937436|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|MG1655|NC_000913|932447|936436|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=G6464 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 950282..954310 <gbrowseImage>
name=NC_012967:950282..954310
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|950282|954310|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|950282|954310|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 835415..839404 <gbrowseImage>
name=NC_012759:835415..839404
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|NC_012759|835415|839404|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|NC_012759|835415|839404|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 933646..937635 <gbrowseImage>
name=AC_000091:933646..937635
source=W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|W3110|AC_000091|932646|938635|GBrowse(W3110)}}
|
{{GBrowseFastaLink|W3110|AC_000091|933646|937635|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 986375..990364 <gbrowseImage>
name=NC_010473:986375..990364
source=DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|DH10B|NC_010473|978397|998342|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|DH10B|NC_010473|978397|998342|FASTA Dump}}

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.V46a9bb01cfcb0&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="U46a9bb0279a81" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.U46a9bb0279a81&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="B46a9bb02b9f16" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔLC
|

|

|

|

|
PMID:15522074
|

|
Carries a deletion of FtsK L and FtsK C
|-
|
''ftsK''G80A
|

|
G80A
|

|
In Toe44; loss of function under extreme conditions
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
ftsKE58A
|

|
E58A
|

|
Loss of function
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
NC
|

|

|

|

|
PMID:15522074
|
Barre
|
Deletion of the FtsK Linker
|-
|
NL hi C
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H. influenzae'' FtsK regions
|-
|
ftsK A
|

|
K997A
|

|

|
PMID:15522074
|
Barre
|
Carries a single point mutation in the walker A motif of FtsK C
|-
|
NLC hi
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H.influenzae'' FtsK regions
|-
|
ftsk::cat1
|

|

|

|

|
PMID:9721304
|
Donachie
Sheratt

|
only expresses the NTD due to a Cm resistance cassette at nt 678 of ''ftsK''
|-
|
''ftsk44''
|
missense mutation
|
G80A
|
Growth Phenotype
|
temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:7592387

PMID:9721304
|
Donachie
|
this is the allele from the TOE44 strain listed in this table.
|-
|
''ftsK1::cat''
|

|

|

|
abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation
|
* PMID:9294448
* PMID:9829960
|

|
defect in the C-terminus of FtsK
|-
|
''ftsK1::cat ΔmukB''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:9829960
|

|
shown that it must be complemented in trans
|-
|
''ftsK::cat-2''
|
Δ54-2201
|

|

|

|
PMID:9721304
|

|
almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the ''cat'' gene. Lethal- must be complemented ''in trans''
|-
|
''ftsK::cat-Δ5''
|
Δ54-3651
|

|

|

|
PMID:9721304
|

|
this is a deletion of 90% of ''ftsK''
|-
|
''ftsK3531''
|
missense mutation
|

|
Growth Phenotype
|
same phenotype as ''ftsK44''- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:9721304
|

|
suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the ''dacA'' gene, encoding PBP5.
|-
|
''ftsK::cat-Δ2 ΔdacA::kan''
|

|

|
Cell Shape
|
*forms small colonies on plates grows well
*produces a population of misshapen cells in liquid culture
|
PMID:9721304
|

|

|-
|
''ftsK::cat-Δ5 Δdac::kan''
|

|

|

|
synthetically lethal
|
PMID:9721304
|

|

|-
|
''ftsKC priA2::kan''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:11459954

|

|

|-
|
''ftsK1::cat ΔminB''
|

|

|
Growth Phenotype
|
chains of minicells generated (many of which contained DNA)
|
PMID:9829960
|

|

|-
|
''ftsK100''
|

|
K997A
|

|
ATP mutant
|
PMID:18363794
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.B46a9bb02b9f16&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_allele_table edit table] || || || || || || ||
|}


<protect></protect>
===Notes===
Deletions that leave the membrane segments intact are viable<ref name='PMID: 9721304'/>. Suppressors of the ''ftsK'' chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.

==Genetic Interactions==
{{BacktoTop}}
<protect>
{{Genetic_interaction_help}}
{| id="X4e04bb9e6c34f" class=" tableEdit Genetic_interaction_table dataTable"
|- {{table_heading_style}}
!|Interactor!!Interaction!!Allele!!Score(s)!!Reference(s)!!Accessions!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.12339.X4e04bb9e6c34f&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Genetic_interaction_table edit table] || || || || || ||
|}
</protect>


===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="R46a9bb0364216" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW0873
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG
|-
|
[[:Category:Kohara_Phage:1F10|1F10]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=214 Genobase]
|
PMID:3038334
|-
|
[[:Category:Kohara_Phage:E6H3|E6H3]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=215 Genobase]
|
PMID:3038334
|-
|
zbh-29::Tn10
|
Linked marker
|
CAG18493 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39400 CGSC7353]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: % <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbi-29::Tn10
|-
|
zca-1230::Tn10
|
Linked marker
|
CAG18478 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39407 CGSC7356]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 61% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbj-1230::Tn10
|-
|
W3110::P''lac-ftsK''
|
Strain
|

|
Depletion Strain<ref name='PMID:9723913'/>
|-
|
pWL71
|
Plasmid Clone
|
Pbad-FtsK(1-202)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain<ref name='PMID:9723913'/>
|-
|
pWL72
|
Plasmid Clone
|
Pbad-FtsK(1-211)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL73
|
Plasmid Clone
|
Pbad-FtsK(1-251)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL74
|
Plasmid Clone
|
Pbad-FtsK(1-644)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL75
|
Plasmid Clone
|
Pbad-FtsK(1-1329)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL76
|
Plasmid Clone
|
Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK
|
Cannot complement the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pFtsK-PhoA plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''phoA'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFtsK-LacZ plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''lacZ'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFLAG-FtsK plasmids
|
Plasmid Clone
|

|
This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG<ref name='PMID:11114887'/>.
|-
|
MA3
|
Strain
|
AB1157''ftsK''
|
PMID:10523315
|-
|
GR51
|
Strain
|
AB1157''xerCftsK''
|
PMID:10523315
|-
|
GR59
|
Strain
|
AB1157''ftsK recA56 srl::Tn10''
|
PMID:10523315
|-
|
FC1
|
Strain
|
AB1157, ''ftsK100'' K997A (ATP mutant), CmR
|
PMID:18363794
|-
|
FtsK-YFP
|
Plasmid Clone
|
*low-copy expression vectors derived from pSC101
*Spectinomycin resistance gene
|
PMID:18363794
|-
|
FtsKΔγ
|
Plasmid Clone
|
FtsK50C deleted from residue 1248
|
PMID:19854947

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.R46a9bb0364216&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_resource_table edit table] || || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46a9bb03edc16" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI] ([[NCBI|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.G46a9bb03edc16&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Y46a6d85840482" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.Y46a6d85840482&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude><protect>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Genes not in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:fts genes]][[Category:Gene_List:DH10B]][[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]

ftsK:Quickview

2011-11-14T19:29:57Z

Whitley: Updating New_Quickview_Table table.

ftsK:Gene

2011-11-14T19:24:25Z

Whitley: Table edited by Whitley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsK}}{{Tab On|Gene|ftsK}}{{Tab|Gene Product(s)|ftsK}}{{Tab|Expression|ftsK}}{{Tab|Evolution|ftsK}}{{Tab|On One Page|ftsK}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Interactions | Genetic Interactions]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="D46a9bb0157a6c" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''ftsK''
|-
!align=left {{table_heading_style}} |Mnemonic
||
filamentation temperature sensitive
Filamentation, temperature sensitive
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>, dinH''

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.D46a9bb0157a6c&page=12339&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="V46a9bb01cfcb0" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
20.1 minutes 
|
MG1655: 932447..936436 <gbrowseImage>
name=NC_000913:932447..936436
source=MG1655
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=G6464 EcoCyc]
{{GBrowseLink|MG1655|NC_000913|931447|937436|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|MG1655|NC_000913|932447|936436|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=G6464 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 950282..954310 <gbrowseImage>
name=NC_012967:950282..954310
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|950282|954310|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|950282|954310|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 835415..839404 <gbrowseImage>
name=NC_012759:835415..839404
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|NC_012759|835415|839404|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|NC_012759|835415|839404|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 933646..937635 <gbrowseImage>
name=AC_000091:933646..937635
source=W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|W3110|AC_000091|932646|938635|GBrowse(W3110)}}
|
{{GBrowseFastaLink|W3110|AC_000091|933646|937635|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 986375..990364 <gbrowseImage>
name=NC_010473:986375..990364
source=DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|DH10B|NC_010473|978397|998342|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|DH10B|NC_010473|978397|998342|FASTA Dump}}

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.V46a9bb01cfcb0&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="U46a9bb0279a81" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.U46a9bb0279a81&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="B46a9bb02b9f16" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔLC
|

|

|

|

|
PMID:15522074
|

|
Carries a deletion of FtsK L and FtsK C
|-
|
''ftsK''G80A
|

|
G80A
|

|
In Toe44; loss of function under extreme conditions
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
ftsKE58A
|

|
E58A
|

|
Loss of function
|

|

|
seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
|-
|
NC
|

|

|

|

|
PMID:15522074
|
Barre
|
Deletion of the FtsK Linker
|-
|
NL hi C
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H. influenzae'' FtsK regions
|-
|
ftsK A
|

|
K997A
|

|

|
PMID:15522074
|
Barre
|
Carries a single point mutation in the walker A motif of FtsK C
|-
|
NLC hi
|

|

|

|

|
PMID:15522074
|
Barre
|
Carries swaps b/t ''E.coli'' and ''H.influenzae'' FtsK regions
|-
|
ftsk::cat1
|

|

|

|

|
PMID:9721304
|
Donachie
Sheratt

|
only expresses the NTD due to a Cm resistance cassette at nt 678 of ''ftsK''
|-
|
''ftsk44''
|
missense mutation
|
G80A
|
Growth Phenotype
|
temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:7592387

PMID:9721304
|
Donachie
|
this is the allele from the TOE44 strain listed in this table.
|-
|
''ftsK1::cat''
|

|

|

|
abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation
|
* PMID:9294448
* PMID:9829960
|

|
defect in the C-terminus of FtsK
|-
|
''ftsK1::cat ΔmukB''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:9829960
|

|
shown that it must be complemented in trans
|-
|
''ftsK::cat-2''
|
Δ54-2201
|

|

|

|
PMID:9721304
|

|
almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the ''cat'' gene. Lethal- must be complemented ''in trans''
|-
|
''ftsK::cat-Δ5''
|
Δ54-3651
|

|

|

|
PMID:9721304
|

|
this is a deletion of 90% of ''ftsK''
|-
|
''ftsK3531''
|
missense mutation
|

|
Growth Phenotype
|
same phenotype as ''ftsK44''- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation
|
PMID:9721304
|

|
suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the ''dacA'' gene, encoding PBP5.
|-
|
''ftsK::cat-Δ2 ΔdacA::kan''
|

|

|
Cell Shape
|
*forms small colonies on plates grows well
*produces a population of misshapen cells in liquid culture
|
PMID:9721304
|

|

|-
|
''ftsK::cat-Δ5 Δdac::kan''
|

|

|

|
synthetically lethal
|
PMID:9721304
|

|

|-
|
''ftsKC priA2::kan''
|

|

|
Growth Phenotype
|
synthetically lethal
|
PMID:11459954

|

|

|-
|
''ftsK1::cat ΔminB''
|

|

|
Growth Phenotype
|
chains of minicells generated (many of which contained DNA)
|
PMID:9829960
|

|

|-
|
''ftsK100''
|

|
K997A
|

|
ATP mutant
|
PMID:18363794
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.12339.B46a9bb02b9f16&page=12339&pagename={{FULLPAGENAMEE}}&type=&template=Gene_allele_table edit table] || || || || || || ||
|}


<protect></protect>
===Notes===
Deletions that leave the membrane segments intact are viable<ref name='PMID: 9721304'/>. Suppressors of the ''ftsK'' chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.

==Genetic Interactions==
{{BacktoTop}}
<protect>
{{Genetic_interaction_help}}
{| id="X4e04bb9e6c34f" class=" tableEdit Genetic_interaction_table dataTable"
|- {{table_heading_style}}
!|Interactor!!Interaction!!Allele!!Score(s)!!Reference(s)!!Accessions!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=bc145ea147f7e36caf09c1bfeed4ee9d.12339.X4e04bb9e6c34f&page=12339&pagename={{FULLPAGENAMEE}}&type=0&template=Genetic_interaction_table edit table] || || || || || ||
|}
</protect>


===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="R46a9bb0364216" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW0873
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG
|-
|
[[:Category:Kohara_Phage:1F10|1F10]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=214 Genobase]
|
PMID:3038334
|-
|
[[:Category:Kohara_Phage:E6H3|E6H3]]
|
Kohara Phage
|
[http://ecoli.aist-nara.ac.jp/GB6/kohara_info.jsp?fword=215 Genobase]
|
PMID:3038334
|-
|
zbh-29::Tn10
|
Linked marker
|
CAG18493 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39400 CGSC7353]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: % <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbi-29::Tn10
|-
|
zca-1230::Tn10
|
Linked marker
|
CAG18478 = [http://cgsc2.biology.yale.edu/Strain.php?ID=39407 CGSC7356]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 61% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zbj-1230::Tn10
|-
|
W3110::P''lac-ftsK''
|
Strain
|

|
Depletion Strain<ref name='PMID:9723913'/>
|-
|
pWL71
|
Plasmid Clone
|
Pbad-FtsK(1-202)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain<ref name='PMID:9723913'/>
|-
|
pWL72
|
Plasmid Clone
|
Pbad-FtsK(1-211)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL73
|
Plasmid Clone
|
Pbad-FtsK(1-251)-GFP
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL74
|
Plasmid Clone
|
Pbad-FtsK(1-644)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL75
|
Plasmid Clone
|
Pbad-FtsK(1-1329)
|
Successfully complements the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pWL76
|
Plasmid Clone
|
Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK
|
Cannot complement the W3110::P''lac-ftsK'' depletion strain <ref name='PMID:9723913'/>
|-
|
pFtsK-PhoA plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''phoA'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFtsK-LacZ plasmids
|
Plasmid Clone
|

|
This represents multiple plasmids with ''lacZ'' inserted at various positions<ref name='PMID:10922461'/>.
|-
|
pFLAG-FtsK plasmids
|
Plasmid Clone
|

|
This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG<ref name='PMID:11114887'/>.
|-
|
MA3
|
Strain
|
AB1157''ftsK''
|
PMID:10523315
|-
|
GR51
|
Strain
|
AB1157''xerCftsK''
|
PMID:10523315
|-
|
GR59
|
Strain
|
AB1157''ftsK recA56 srl::Tn10''
|
PMID:10523315
|-
|
FC1
|
Strain
|
AB1157, ''ftsK100'' K997A (ATP mutant), CmR
|
PMID:18363794
|-
|
FtsK-YFP
|
Plasmid Clone
|
*low-copy expression vectors derived from pSC101
*Spectinomycin resistance gene
|
PMID:18363794
|-
|
FtsKΔγ
|
Plasmid Clone
|
FtsK50C deleted from residue 1248
|
PMID:19854947

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===Notes===

==Accessions in Other Databases==
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{{Gene_accessions_help}}
{| id="G46a9bb03edc16" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6464 ECOCYC:G6464]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG13226 EcoGene:EG13226]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI] ([[NCBI|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=945102 GeneID:945102]
|
Escherichia coli str. K-12 substr. MG1655

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===Notes===

==Links==
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{| id="Y46a6d85840482" class=" tableEdit Links_table"
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!|Name!!URL!!Comments

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<noinclude><protect>
==References==
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{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Genes not in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:fts genes]][[Category:Gene_List:DH10B]][[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]

ftsQ:Gene

2011-11-14T19:20:17Z

Whitley: Table edited by Whitley via TableEdit