EcoliWiki - User contributions [en]

hcaC:Gene Product(s)

2010-05-03T23:47:44Z

Roystefan: Table edited by Roystefan via TableEdit

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<noinclude>{{TabsTop}}
{{Tab|Quickview|hcaC}}{{Tab|Gene|hcaC}}{{Tab On|Gene Product(s)|hcaC}}{{Tab|Expression|hcaC}}{{Tab|Evolution|hcaC}}{{Tab|On One Page|hcaC}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="G46aaae7beae3a" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
HcaC
|-
!align=left {{table heading style}} |Synonyms
||
3-phenylpropionate dioxygenase, predicted ferredoxin subunit<ref name='LIB:Riley_2006'/>, B2540<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YfhW<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PhdB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HcaC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
ferredoxin, 3-phenylpropionate dioxygenase system<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:3-phenylpropionate dioxygenase system|3-phenylpropionate dioxygenase system]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

3-phenylpropionate/cinnamic acid dioxygenase, ferredoxin subunit; hca genes catabolize 3-phenylpropionate and cinnamic acid, feeding the products into the the mhp pathway<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="T46aaae7d68754" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051537
|
2 iron, 2 sulfur cluster binding
|
PMID:18286376
|
IEA: Inferred from Electronic Annotation
|

|
F
|

|
complete
|-
|

|
GO:0005506
|
iron ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0408
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006810
|
transport
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0813
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005806
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0019439
|
aromatic compound catabolic process
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0058
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0046872
|
metal ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0479
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0051536
|
iron-sulfur cluster binding
|
PMID:18286376
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0051537
|
2 iron, 2 sulfur cluster binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0001
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0016052
|
carbohydrate catabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0008695
|
3-phenylpropionate dioxygenase activity
|
GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01650
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0009055
|
electron carrier activity
|
GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005806 InterPro:IPR017941
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0022900
|
electron transport chain
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0249
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005806 InterPro:IPR017941
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="Z46aaae8098ac3" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:3-phenylpropionate dioxygenase system|3-phenylpropionate dioxygenase system]]
|
could be indirect
|

|

|-
|
Protein
|
iscS 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 
|-
|
Protein
|
cydD 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 
|-
|
Protein
|
dnaK 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 
|-
|
Protein
|
ihfB 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 

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</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="S46a846ec22e65" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
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<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="C46aaae82f1bc2" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=HCAC-MONOMER at EcoCyc]
<pre>MNRIYACPVA DVPEGEALRI DTSPVIALFN VGGEFYAIND RCSHGNASMS EGYLEDDATV
ECPLHAASFC LKTGKALCLP ATDPLTTYPV HVEGGDIFID LPEAQP</pre>
|-
!align=left {{table heading style}} |Length
||
106
|-
!align=left {{table heading style}} |Mol. Wt
||
11.328 kDa
|-
!align=left {{table heading style}} |pI
||
4.1 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
5,960 - 6,585 (calc based on 4 Y, W, and 5 C residues)

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<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="O46aaae836d09f" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="Z46a846edc168f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hcaC
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aaae843628a" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="E46aaae8494322" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=HCAC-MONOMER EcoCyc:HCAC-MONOMER]
|

|-
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0ABW0 SwissModel:P0ABW0]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0ABW0|UniProt:P0ABW0]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF00355 PFAM:PF00355]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_417035 RefSeq:NP_417035]
|

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<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="L46a846f21f116" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0016052_!_carbohydrate catabolic process]][[Category:Complex:3-phenylpropionate dioxygenase system]]

hemA:Gene Product(s)

2010-05-03T23:43:28Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|gtrA}}{{Tab|Gene|gtrA}}{{Tab On|Gene Product(s)|gtrA}}{{Tab|Expression|gtrA}}{{Tab|Evolution|gtrA}}{{Tab|On One Page|gtrA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa5c8610015" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
GtrA
|-
!align=left {{table heading style}} |Synonyms
||
glutamyl tRNA reductase<ref name='LIB:Riley_2006'/>, B1210<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
GLUTRNAREDUCT<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]<ref name='LIB:EcoCyc11.1'/>

Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.- 1.2.1.-]<ref name='LIB:Riley_2006'/>

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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa5c87698b2" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0004764
|
shikimate 5-dehydrogenase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006779
|
porphyrin biosynthetic process
|
GO_REF:0000004 GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0627 HAMAP:MF_00087
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0008883
|
glutamyl-tRNA reductase activity
|
PMID:9732527
PMID:10491185
PMID:16122943
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050661
|
NADP or NADPH binding
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
PMID:10491185
PMID:16122943
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005488
|
binding
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0008152
|
metabolic process
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|

|
complete
|-
|

|
GO:0006783
|
heme biosynthetic process
|
PMID:12697336
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete

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<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="M46aa5c93b1b71" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]
|
could be indirect
|

|

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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="P46a7ef73ab4ed" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
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<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="L46aa5c95d40ee" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=GLUTRNAREDUCT-MONOMER at EcoCyc]
<pre>MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE
EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ
VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL
STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL
READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV
DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT
AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE</pre>
|-
!align=left {{table heading style}} |Length
||
418
|-
!align=left {{table heading style}} |Mol. Wt
||
46.307 kDa
|-
!align=left {{table heading style}} |pI
||
5.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c95d40ee&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="E46aa5c963d018" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.E46aa5c963d018&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7ef755a812" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hemA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.X46a7ef755a812&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aa5c96d854f" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c96d854f&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Y46aa5c973157a" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=GLUTRNAREDUCT-MONOMER EcoCyc:GLUTRNAREDUCT-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0A6X1|UniProt:P0A6X1]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF05201 PFAM:PF05201]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415728 RefSeq:NP_415728]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.Y46aa5c973157a&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="A46a7ef78b8392" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46a7ef78b8392&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0042493_!_response to drug]][[Category:GO:0006779_!_porphyrin biosynthetic process]][[Category:Complex:glutamyl-tRNA reductase]]

hisP:Gene Product(s)

2010-05-03T23:40:58Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|hisP}}{{Tab|Gene|hisP}}{{Tab On|Gene Product(s)|hisP}}{{Tab|Expression|hisP}}{{Tab|Evolution|hisP}}{{Tab|On One Page|hisP}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="V46aaa05c49d42" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
HisP
|-
!align=left {{table heading style}} |Synonyms
||
histidine/lysine/arginine/ornithine transporter subunit<ref name='LIB:Riley_2006'/>, ATP-binding component of ABC superfamily<ref name='LIB:Riley_2006'/>, B2306<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HisP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
HisP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Histidine permease<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.V46aaa05c49d42&page=24820&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="Q46aaa05d6176f" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005515
|
protein binding
|
PMID:16606699
|
IPI: Inferred from Physical Interaction
|
UniProtKB:P0A6F5
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003593 SP_KW:KW-0547
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003439 SP_KW:KW-0067
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0006810
|
transport
|
PMID:4920090
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0006865
|
amino acid transport
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0029
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0016020
|
membrane
|
GO_REF:0000004 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0397 SP_KW:KW-0472
|
C
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003439
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0017111
|
nucleoside-triphosphatase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003593
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0009063
|
amino acid catabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005886
|
plasma membrane
|
GO_REF:0000004 GO_REF:0000004 GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0009089
|
lysine biosynthetic process via diaminopimelate
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0000105
|
histidine biosynthetic process
|
PMID:4920090
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0006526
|
arginine biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.Q46aaa05d6176f&page=24820&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="G46aaa074bed72" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
groL 
|

|
PMID:16606699
|
Experiment(s):EBI-1142524 

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.G46aaa074bed72&page=24820&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="F46aaa07583b34" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.F46aaa07583b34&page=24820&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="J46aaa0771f0ea" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=HISP-MONOMER at EcoCyc]
<pre>MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC INFLEKPSEG
SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH FNLWSHMTVL ENVMEAPIQV
LGLSKQEARE RAVKYLAKVG IDERAQGKYP VHLSGGQQQR VSIARALAME PEVLLFDEPT
SALDPELVGE VLRIMQQLAE EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF
GNPQSPRLQR FLKGSLK</pre>
|-
!align=left {{table heading style}} |Length
||
257
|-
!align=left {{table heading style}} |Mol. Wt
||
28.652 kDa
|-
!align=left {{table heading style}} |pI
||
8.1 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,095 (calc based on 3 Y, 1 W, and 1 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.J46aaa0771f0ea&page=24820&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="Y46aaa0778d078" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.Y46aaa0778d078&page=24820&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="E46a837abe2e78" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hisP
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.E46a837abe2e78&page=24820&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="H46aaa07853b40" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.H46aaa07853b40&page=24820&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="T46aaa078b09f2" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=HISP-MONOMER EcoCyc:HISP-MONOMER]
|

|-
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P07109 SwissModel:P07109]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P07109|UniProt:P07109]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF00005 PFAM:PF00005]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_416809 RefSeq:NP_416809]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.T46aaa078b09f2&page=24820&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="O46a837b0b8be0" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.24820.O46a837b0b8be0&page=24820&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0009063_!_amino acid catabolic process]][[Category:GO:0009089_!_lysine biosynthetic process via diaminopimelate]][[Category:GO:0000105_!_histidine biosynthetic process]][[Category:GO:0006526_!_arginine biosynthetic process]][[Category:GO:0005737_!_cytoplasm]][[Category:Location:cytoplasm]]

hemA:Gene Product(s)

2010-05-03T23:39:14Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|gtrA}}{{Tab|Gene|gtrA}}{{Tab On|Gene Product(s)|gtrA}}{{Tab|Expression|gtrA}}{{Tab|Evolution|gtrA}}{{Tab|On One Page|gtrA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa5c8610015" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
GtrA
|-
!align=left {{table heading style}} |Synonyms
||
glutamyl tRNA reductase<ref name='LIB:Riley_2006'/>, B1210<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
GLUTRNAREDUCT<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]<ref name='LIB:EcoCyc11.1'/>

Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.- 1.2.1.-]<ref name='LIB:Riley_2006'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.B46aa5c8610015&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa5c87698b2" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0004764
|
shikimate 5-dehydrogenase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006779
|
porphyrin biosynthetic process
|
GO_REF:0000004 GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0627 HAMAP:MF_00087
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0008883
|
glutamyl-tRNA reductase activity
|
PMID:9732527
PMID:10491185
PMID:16122943
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050661
|
NADP or NADPH binding
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
PMID:10491185
PMID:16122943
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005488
|
binding
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0008152
|
metabolic process
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46aa5c87698b2&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="M46aa5c93b1b71" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]
|
could be indirect
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.M46aa5c93b1b71&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="P46a7ef73ab4ed" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.P46a7ef73ab4ed&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="L46aa5c95d40ee" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=GLUTRNAREDUCT-MONOMER at EcoCyc]
<pre>MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE
EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ
VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL
STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL
READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV
DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT
AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE</pre>
|-
!align=left {{table heading style}} |Length
||
418
|-
!align=left {{table heading style}} |Mol. Wt
||
46.307 kDa
|-
!align=left {{table heading style}} |pI
||
5.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c95d40ee&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="E46aa5c963d018" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.E46aa5c963d018&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7ef755a812" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hemA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.X46a7ef755a812&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aa5c96d854f" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c96d854f&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Y46aa5c973157a" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=GLUTRNAREDUCT-MONOMER EcoCyc:GLUTRNAREDUCT-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0A6X1|UniProt:P0A6X1]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF05201 PFAM:PF05201]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415728 RefSeq:NP_415728]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.Y46aa5c973157a&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="A46a7ef78b8392" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46a7ef78b8392&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0042493_!_response to drug]][[Category:GO:0006779_!_porphyrin biosynthetic process]][[Category:Complex:glutamyl-tRNA reductase]]

hemA:Gene Product(s)

2010-05-03T23:34:46Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|gtrA}}{{Tab|Gene|gtrA}}{{Tab On|Gene Product(s)|gtrA}}{{Tab|Expression|gtrA}}{{Tab|Evolution|gtrA}}{{Tab|On One Page|gtrA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa5c8610015" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
GtrA
|-
!align=left {{table heading style}} |Synonyms
||
glutamyl tRNA reductase<ref name='LIB:Riley_2006'/>, B1210<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
GLUTRNAREDUCT<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]<ref name='LIB:EcoCyc11.1'/>

Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.- 1.2.1.-]<ref name='LIB:Riley_2006'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.B46aa5c8610015&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa5c87698b2" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0004764
|
shikimate 5-dehydrogenase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006779
|
porphyrin biosynthetic process
|
GO_REF:0000004 GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0627 HAMAP:MF_00087
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0008883
|
glutamyl-tRNA reductase activity
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050661
|
NADP or NADPH binding
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005488
|
binding
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0008152
|
metabolic process
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46aa5c87698b2&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="M46aa5c93b1b71" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]
|
could be indirect
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.M46aa5c93b1b71&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="P46a7ef73ab4ed" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.P46a7ef73ab4ed&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="L46aa5c95d40ee" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=GLUTRNAREDUCT-MONOMER at EcoCyc]
<pre>MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE
EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ
VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL
STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL
READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV
DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT
AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE</pre>
|-
!align=left {{table heading style}} |Length
||
418
|-
!align=left {{table heading style}} |Mol. Wt
||
46.307 kDa
|-
!align=left {{table heading style}} |pI
||
5.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c95d40ee&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="E46aa5c963d018" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.E46aa5c963d018&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7ef755a812" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hemA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.X46a7ef755a812&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aa5c96d854f" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c96d854f&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Y46aa5c973157a" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=GLUTRNAREDUCT-MONOMER EcoCyc:GLUTRNAREDUCT-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0A6X1|UniProt:P0A6X1]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF05201 PFAM:PF05201]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415728 RefSeq:NP_415728]
|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="A46a7ef78b8392" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46a7ef78b8392&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0042493_!_response to drug]][[Category:GO:0006779_!_porphyrin biosynthetic process]][[Category:Complex:glutamyl-tRNA reductase]]

hemA:Gene Product(s)

2010-05-03T23:32:24Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|gtrA}}{{Tab|Gene|gtrA}}{{Tab On|Gene Product(s)|gtrA}}{{Tab|Expression|gtrA}}{{Tab|Evolution|gtrA}}{{Tab|On One Page|gtrA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa5c8610015" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
GtrA
|-
!align=left {{table heading style}} |Synonyms
||
glutamyl tRNA reductase<ref name='LIB:Riley_2006'/>, B1210<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
GLUTRNAREDUCT<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]<ref name='LIB:EcoCyc11.1'/>

Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.- 1.2.1.-]<ref name='LIB:Riley_2006'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.B46aa5c8610015&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa5c87698b2" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0004764
|
shikimate 5-dehydrogenase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006779
|
porphyrin biosynthetic process
|
GO_REF:0000004 GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0627 HAMAP:MF_00087
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0008883
|
glutamyl-tRNA reductase activity
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050661
|
NADP or NADPH binding
|

|
IEA: Inferred from Electronic Annotation
|

|
F
|

|
Missing: reference
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005488
|
binding
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0008152
|
metabolic process
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46aa5c87698b2&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="M46aa5c93b1b71" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]
|
could be indirect
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.M46aa5c93b1b71&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="P46a7ef73ab4ed" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="L46aa5c95d40ee" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=GLUTRNAREDUCT-MONOMER at EcoCyc]
<pre>MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE
EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ
VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL
STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL
READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV
DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT
AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE</pre>
|-
!align=left {{table heading style}} |Length
||
418
|-
!align=left {{table heading style}} |Mol. Wt
||
46.307 kDa
|-
!align=left {{table heading style}} |pI
||
5.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="E46aa5c963d018" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.E46aa5c963d018&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7ef755a812" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hemA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aa5c96d854f" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c96d854f&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Y46aa5c973157a" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=GLUTRNAREDUCT-MONOMER EcoCyc:GLUTRNAREDUCT-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0A6X1|UniProt:P0A6X1]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF05201 PFAM:PF05201]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415728 RefSeq:NP_415728]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.Y46aa5c973157a&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="A46a7ef78b8392" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46a7ef78b8392&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0042493_!_response to drug]][[Category:GO:0006779_!_porphyrin biosynthetic process]][[Category:Complex:glutamyl-tRNA reductase]]

hemA:Gene Product(s)

2010-05-03T23:28:46Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|gtrA}}{{Tab|Gene|gtrA}}{{Tab On|Gene Product(s)|gtrA}}{{Tab|Expression|gtrA}}{{Tab|Evolution|gtrA}}{{Tab|On One Page|gtrA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa5c8610015" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
GtrA
|-
!align=left {{table heading style}} |Synonyms
||
glutamyl tRNA reductase<ref name='LIB:Riley_2006'/>, B1210<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
GLUTRNAREDUCT<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]<ref name='LIB:EcoCyc11.1'/>

Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.- 1.2.1.-]<ref name='LIB:Riley_2006'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.B46aa5c8610015&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa5c87698b2" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0004764
|
shikimate 5-dehydrogenase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006779
|
porphyrin biosynthetic process
|
GO_REF:0000004 GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0627 HAMAP:MF_00087
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0008883
|
glutamyl-tRNA reductase activity
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050661
|
NADP or NADPH binding
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005488
|
binding
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0008152
|
metabolic process
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46aa5c87698b2&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="M46aa5c93b1b71" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]
|
could be indirect
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.M46aa5c93b1b71&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="P46a7ef73ab4ed" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.P46a7ef73ab4ed&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="L46aa5c95d40ee" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=GLUTRNAREDUCT-MONOMER at EcoCyc]
<pre>MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE
EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ
VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL
STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL
READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV
DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT
AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE</pre>
|-
!align=left {{table heading style}} |Length
||
418
|-
!align=left {{table heading style}} |Mol. Wt
||
46.307 kDa
|-
!align=left {{table heading style}} |pI
||
5.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c95d40ee&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="E46aa5c963d018" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.E46aa5c963d018&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7ef755a812" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hemA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.X46a7ef755a812&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aa5c96d854f" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c96d854f&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Y46aa5c973157a" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=GLUTRNAREDUCT-MONOMER EcoCyc:GLUTRNAREDUCT-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0A6X1|UniProt:P0A6X1]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF05201 PFAM:PF05201]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415728 RefSeq:NP_415728]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.Y46aa5c973157a&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="A46a7ef78b8392" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46a7ef78b8392&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0042493_!_response to drug]][[Category:GO:0006779_!_porphyrin biosynthetic process]][[Category:Complex:glutamyl-tRNA reductase]]

hemA:Gene Product(s)

2010-05-03T23:27:25Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|gtrA}}{{Tab|Gene|gtrA}}{{Tab On|Gene Product(s)|gtrA}}{{Tab|Expression|gtrA}}{{Tab|Evolution|gtrA}}{{Tab|On One Page|gtrA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aa5c8610015" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
GtrA
|-
!align=left {{table heading style}} |Synonyms
||
glutamyl tRNA reductase<ref name='LIB:Riley_2006'/>, B1210<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
GLUTRNAREDUCT<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]<ref name='LIB:EcoCyc11.1'/>

Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.- 1.2.1.-]<ref name='LIB:Riley_2006'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.B46aa5c8610015&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa5c87698b2" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0004764
|
shikimate 5-dehydrogenase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006151
|
C
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006779
|
porphyrin biosynthetic process
|
GO_REF:0000004 GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0627 HAMAP:MF_00087
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0008883
|
glutamyl-tRNA reductase activity
|
PMID:9732527
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050661
|
NADP or NADPH binding
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000343 InterPro:IPR015895 InterPro:IPR015896
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005488
|
binding
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0008152
|
metabolic process
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016040
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0560
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003870
|
5-aminolevulinate synthase activity
|
PMID:2548996
|
IMP: Inferred from Mutant Phenotype
|

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46aa5c87698b2&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="M46aa5c93b1b71" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:glutamyl-tRNA reductase|glutamyl-tRNA reductase]]
|
could be indirect
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.M46aa5c93b1b71&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="P46a7ef73ab4ed" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.P46a7ef73ab4ed&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="L46aa5c95d40ee" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=GLUTRNAREDUCT-MONOMER at EcoCyc]
<pre>MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE
EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ
VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL
STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL
READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV
DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT
AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE</pre>
|-
!align=left {{table heading style}} |Length
||
418
|-
!align=left {{table heading style}} |Mol. Wt
||
46.307 kDa
|-
!align=left {{table heading style}} |pI
||
5.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
30,940 - 31,315 (calc based on 6 Y, 4 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c95d40ee&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="E46aa5c963d018" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.E46aa5c963d018&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7ef755a812" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hemA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.X46a7ef755a812&page=22352&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aa5c96d854f" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.L46aa5c96d854f&page=22352&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Y46aa5c973157a" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=GLUTRNAREDUCT-MONOMER EcoCyc:GLUTRNAREDUCT-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0A6X1|UniProt:P0A6X1]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF05201 PFAM:PF05201]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415728 RefSeq:NP_415728]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.Y46aa5c973157a&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="A46a7ef78b8392" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22352.A46a7ef78b8392&page=22352&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0042493_!_response to drug]][[Category:GO:0006779_!_porphyrin biosynthetic process]][[Category:Complex:glutamyl-tRNA reductase]]

hcp:Gene Product(s)

2010-05-03T23:25:48Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|hcp}}{{Tab|Gene|hcp}}{{Tab On|Gene Product(s)|hcp}}{{Tab|Expression|hcp}}{{Tab|Evolution|hcp}}{{Tab|On One Page|hcp}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="G46aa4881ebba5" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
Hcp
|-
!align=left {{table heading style}} |Synonyms
||
hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases<ref name='LIB:Riley_2006'/>, Hcp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, B0873<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbjW<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PriS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, fuscoredoxin<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, prismane protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
hybrid-cluster protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Hydroxylamine reductase, hybrid-cluster [2Fe-2S] protein <ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.G46aa4881ebba5&page=21571&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa4882f2d23" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051537
|
2 iron, 2 sulfur cluster binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0001
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0051536
|
iron-sulfur cluster binding
|
GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR010048 SP_KW:KW-0411
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011254
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0005506
|
iron ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0408
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004137 InterPro:IPR010048 SP_KW:KW-0963
|
C
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
PMID:16928682
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0016661
|
oxidoreductase activity, acting on other nitrogenous compounds as donors
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR010048
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0046872
|
metal ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0479
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050418
|
hydroxylamine reductase activity
|
GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00069
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:16606699
|
IPI: Inferred from Physical Interaction
|
UniProtKB:P07003
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006807
|
nitrogen compound metabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009055
|
electron carrier activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004137
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
PMID:16928682
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.A46aa4882f2d23&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="G46aa4885c32ce" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
poxB 
|

|
PMID:16606699
|
Experiment(s):EBI-1138223 

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.G46aa4885c32ce&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="O46a7da4af36c3" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.O46a7da4af36c3&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="O46aa48878c530" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6457-MONOMER at EcoCyc]
<pre>MIMFCVQCEQ TIRTPAGNGC SYAQGMCGKT AETSDLQDLL IAALQGLSAW AVKAREYGII
NHDVDSFAPR AFFSTLTNVN FDSPRIVGYA REAIALREAL KAQCLAVDAN ARVDNPMADL
QLVSDDLGEL QRQAAEFTPN KDKAAIGENI LGLRLLCLYG LKGAAAYMEH AHVLGQYDND
IYAQYHKIMA WLGTWPADMN ALLECSMEIG QMNFKVMSIL DAGETGKYGH PTPTQVNVKA
TAGKCILISG HDLKDLYNLL EQTEGTGVNV YTHGEMLPAH GYPELRKFKH LVGNYGSGWQ
NQQVEFARFP GPIVMTSNCI IDPTVGAYDD RIWTRSIVGW PGVRHLDGDD FSAVITQAQQ
MAGFPYSEIP HLITVGFGRQ TLLGAADTLI DLVSREKLRH IFLLGGCDGA RGERHYFTDF
ATSVPDDCLI LTLACGKYRF NKLEFGDIEG LPRLVDAGQC NDAYSAIILA VTLAEKLGCG
VNDLPLSLVL SWFEQKAIVI LLTLLSLGVK NIVTGPTAPG FLTPDLLAVL NEKFGLRSIT
TVEEDMKQLL SA</pre>
|-
!align=left {{table heading style}} |Length
||
552
|-
!align=left {{table heading style}} |Mol. Wt
||
60.309 kDa
|-
!align=left {{table heading style}} |pI
||
5.1 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
65,320 - 67,070 (calc based on 18 Y, 7 W, and 14 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.O46aa48878c530&page=21571&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="N46aa4887e84b9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.N46aa4887e84b9&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="O46a7da4c9d05f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hcp
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.O46a7da4c9d05f&page=21571&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="F46aa48888e461" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.F46aa48888e461&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Z46aa4888db079" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6457-MONOMER EcoCyc:G6457-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P75825|UniProt:P75825]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF03063 PFAM:PF03063]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415394 RefSeq:NP_415394]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.Z46aa4888db079&page=21571&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="J46a7da5042598" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.J46a7da5042598&page=21571&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0006807_!_nitrogen compound metabolic process]]

PMID:16928682

2010-05-03T23:23:09Z

Roystefan: Fill PMID: Page!

{{RightTOC}}
<protect>
 '''Almeida, CC, Romão, CV, Lindley, PF, Teixeira, M and Saraiva, LM''' (2006) The role of the hybrid cluster protein in oxidative stress defense.''J. Biol. Chem.'' '''281''':32445-50

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>Hybrid cluster proteins (HCP) contain two types of Fe/S clusters, namely a [4Fe-4S](2+/1+) or [2Fe-2S](2+/1+) cluster and a novel type of hybrid cluster, [4Fe-2S-2O], in the as-isolated state. Although first isolated from anaerobic sulfate-reducing bacteria, the analysis of the genomic sequences reveals that genes encoding putative hybrid cluster proteins are present in a wide range of organisms, aerobic, anaerobic, or facultative, from the Bacteria, Archaea, and Eukarya domains. Despite a detailed spectroscopic and structural characterization, the precise physiological function of these proteins remained unknown. The present work shows that the transcription of the Escherichia coli hcp gene is induced by hydrogen peroxide, and this induction is regulated by the redox-sensitive transcriptional activator, OxyR. The E. coli hcp mutant strain exhibits higher sensitivity to hydrogen peroxide, a behavior that reverts to the wild type phenotype once a plasmid carrying the hcp gene is reintroduced. Furthermore, the purified HCPs from E. coli and Desulfovibrio desulfuricans ATCC 27774 show an alternative enzymatic activity, which under physiological conditions exhibited K(m) values for hydrogen peroxide (approximately 0.3 mM) within the range of other peroxidases. Altogether, the results reveal that HCP is involved in oxidative stress protection.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16928682 PubMed]
Online version:[http://dx.doi.org/10.1074/jbc.M605888200 10.1074/jbc.M605888200]
|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{| id="T4bdf5add76e2d" class=" tableEdit GO_table_reference"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.171943.T4bdf5add76e2d&page=171943&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==See also==

==References==
{{RefHelp}}
<references/>

PMID:16928682

2010-05-03T23:23:09Z

Roystefan: New PMID: Page!

hcp:Gene Product(s)

2010-05-03T23:22:47Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|hcp}}{{Tab|Gene|hcp}}{{Tab On|Gene Product(s)|hcp}}{{Tab|Expression|hcp}}{{Tab|Evolution|hcp}}{{Tab|On One Page|hcp}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="G46aa4881ebba5" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
Hcp
|-
!align=left {{table heading style}} |Synonyms
||
hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases<ref name='LIB:Riley_2006'/>, Hcp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, B0873<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbjW<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PriS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, fuscoredoxin<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, prismane protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
hybrid-cluster protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Hydroxylamine reductase, hybrid-cluster [2Fe-2S] protein <ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.G46aa4881ebba5&page=21571&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="A46aa4882f2d23" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051537
|
2 iron, 2 sulfur cluster binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0001
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0051536
|
iron-sulfur cluster binding
|
GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR010048 SP_KW:KW-0411
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0003824
|
catalytic activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011254
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0005506
|
iron ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0408
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000002 GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004137 InterPro:IPR010048 SP_KW:KW-0963
|
C
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000002 GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004137 SP_KW:KW-0560
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0016661
|
oxidoreductase activity, acting on other nitrogenous compounds as donors
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR010048
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0046872
|
metal ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0479
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0050418
|
hydroxylamine reductase activity
|
GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00069
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:16606699
|
IPI: Inferred from Physical Interaction
|
UniProtKB:P07003
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006807
|
nitrogen compound metabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009055
|
electron carrier activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR004137
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
PMID:16928682
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.A46aa4882f2d23&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="G46aa4885c32ce" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
poxB 
|

|
PMID:16606699
|
Experiment(s):EBI-1138223 

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.G46aa4885c32ce&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="O46a7da4af36c3" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.O46a7da4af36c3&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="O46aa48878c530" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6457-MONOMER at EcoCyc]
<pre>MIMFCVQCEQ TIRTPAGNGC SYAQGMCGKT AETSDLQDLL IAALQGLSAW AVKAREYGII
NHDVDSFAPR AFFSTLTNVN FDSPRIVGYA REAIALREAL KAQCLAVDAN ARVDNPMADL
QLVSDDLGEL QRQAAEFTPN KDKAAIGENI LGLRLLCLYG LKGAAAYMEH AHVLGQYDND
IYAQYHKIMA WLGTWPADMN ALLECSMEIG QMNFKVMSIL DAGETGKYGH PTPTQVNVKA
TAGKCILISG HDLKDLYNLL EQTEGTGVNV YTHGEMLPAH GYPELRKFKH LVGNYGSGWQ
NQQVEFARFP GPIVMTSNCI IDPTVGAYDD RIWTRSIVGW PGVRHLDGDD FSAVITQAQQ
MAGFPYSEIP HLITVGFGRQ TLLGAADTLI DLVSREKLRH IFLLGGCDGA RGERHYFTDF
ATSVPDDCLI LTLACGKYRF NKLEFGDIEG LPRLVDAGQC NDAYSAIILA VTLAEKLGCG
VNDLPLSLVL SWFEQKAIVI LLTLLSLGVK NIVTGPTAPG FLTPDLLAVL NEKFGLRSIT
TVEEDMKQLL SA</pre>
|-
!align=left {{table heading style}} |Length
||
552
|-
!align=left {{table heading style}} |Mol. Wt
||
60.309 kDa
|-
!align=left {{table heading style}} |pI
||
5.1 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
65,320 - 67,070 (calc based on 18 Y, 7 W, and 14 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.O46aa48878c530&page=21571&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="N46aa4887e84b9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.N46aa4887e84b9&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="O46a7da4c9d05f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hcp
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.O46a7da4c9d05f&page=21571&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="F46aa48888e461" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.F46aa48888e461&page=21571&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="Z46aa4888db079" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6457-MONOMER EcoCyc:G6457-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P75825|UniProt:P75825]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF03063 PFAM:PF03063]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415394 RefSeq:NP_415394]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.Z46aa4888db079&page=21571&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="J46a7da5042598" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.21571.J46a7da5042598&page=21571&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0006807_!_nitrogen compound metabolic process]]

hcaC:Gene Product(s)

2010-05-03T23:20:01Z

Roystefan: Table edited by Roystefan via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|hcaC}}{{Tab|Gene|hcaC}}{{Tab On|Gene Product(s)|hcaC}}{{Tab|Expression|hcaC}}{{Tab|Evolution|hcaC}}{{Tab|On One Page|hcaC}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="G46aaae7beae3a" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
HcaC
|-
!align=left {{table heading style}} |Synonyms
||
3-phenylpropionate dioxygenase, predicted ferredoxin subunit<ref name='LIB:Riley_2006'/>, B2540<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YfhW<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PhdB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HcaC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
ferredoxin, 3-phenylpropionate dioxygenase system<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:3-phenylpropionate dioxygenase system|3-phenylpropionate dioxygenase system]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

3-phenylpropionate/cinnamic acid dioxygenase, ferredoxin subunit; hca genes catabolize 3-phenylpropionate and cinnamic acid, feeding the products into the the mhp pathway<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.G46aaae7beae3a&page=25365&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="T46aaae7d68754" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0051537
|
2 iron, 2 sulfur cluster binding
|
PMID:18286376
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005506
|
iron ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0408
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0006810
|
transport
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0813
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0016491
|
oxidoreductase activity
|
GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005806
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0019439
|
aromatic compound catabolic process
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0058
|
P
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0046872
|
metal ion binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0479
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0051536
|
iron-sulfur cluster binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0411
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0051537
|
2 iron, 2 sulfur cluster binding
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0001
|
F
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
|
complete
|-
|

|
GO:0016052
|
carbohydrate catabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0008695
|
3-phenylpropionate dioxygenase activity
|
GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01650
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0009055
|
electron carrier activity
|
GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005806 InterPro:IPR017941
|
F
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0022900
|
electron transport chain
|
GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0249
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete
|-
|

|
GO:0055114
|
oxidation reduction
|
GO_REF:0000002 GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005806 InterPro:IPR017941
|
P
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.T46aaae7d68754&page=25365&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="Z46aaae8098ac3" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:3-phenylpropionate dioxygenase system|3-phenylpropionate dioxygenase system]]
|
could be indirect
|

|

|-
|
Protein
|
iscS 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 
|-
|
Protein
|
cydD 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 
|-
|
Protein
|
dnaK 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 
|-
|
Protein
|
ihfB 
|

|
PMID:16606699
|
Experiment(s):EBI-1143195 

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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="S46a846ec22e65" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.S46a846ec22e65&page=25365&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="C46aaae82f1bc2" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=HCAC-MONOMER at EcoCyc]
<pre>MNRIYACPVA DVPEGEALRI DTSPVIALFN VGGEFYAIND RCSHGNASMS EGYLEDDATV
ECPLHAASFC LKTGKALCLP ATDPLTTYPV HVEGGDIFID LPEAQP</pre>
|-
!align=left {{table heading style}} |Length
||
106
|-
!align=left {{table heading style}} |Mol. Wt
||
11.328 kDa
|-
!align=left {{table heading style}} |pI
||
4.1 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
5,960 - 6,585 (calc based on 4 Y, W, and 5 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.C46aaae82f1bc2&page=25365&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="O46aaae836d09f" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.O46aaae836d09f&page=25365&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="Z46a846edc168f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=hcaC
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.Z46a846edc168f&page=25365&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="L46aaae843628a" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.L46aaae843628a&page=25365&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="E46aaae8494322" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=HCAC-MONOMER EcoCyc:HCAC-MONOMER]
|

|-
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0ABW0 SwissModel:P0ABW0]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[[uniprot:P0ABW0|UniProt:P0ABW0]]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.sanger.ac.uk/family?acc=PF00355 PFAM:PF00355]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_417035 RefSeq:NP_417035]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.E46aaae8494322&page=25365&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="L46a846f21f116" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25365.L46a846f21f116&page=25365&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:GO:0016052_!_carbohydrate catabolic process]][[Category:Complex:3-phenylpropionate dioxygenase system]]