EcoliWiki - User contributions [en]

fnr:Gene Product(s)

2007-08-07T03:08:52Z

Pjkiley: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|fnr}}{{Tab|Gene|fnr}}{{Tab On|Gene Product(s)|fnr}}{{Tab|Expression|fnr}}{{Tab|Evolution|fnr}}{{Tab|On One Page|fnr}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
Fnr product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional dual regulator, global regulator of anaerobic growth product<ref name='LIB:Riley_2006'/>, B1334 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fnr product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OssA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, transcriptional regulation of aerobic, anaerobic respiration, osmotic balance product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OxrA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
FNR transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa642929c41&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===
FNR is a global regulator, belonging to the CRP superfamily of helix turn helix DNA binding proteins. FNR is active under anaerobic conditions and depending on the location of the binding site, either activates or represses genes. The oxygen sensing function of FNR is mediated by a [4Fe-4S] cluster. The [4Fe-4S] cluster is ligated to Cys20, 23, 29 and 122, is stable anaerobically and promotes FNR dimerization. In the presence of oxygen, the cluster is converted to a [2Fe-2S] cluster decreasing FNR dimerization, DNA binding and inactivating FNR.

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='161237'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009061
|
anaerobic respiration
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.Q46aa642a45f7a&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='161238'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
self
|
detectable dimerization requires ligation of the [4Fe-4S] cluster
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.F46aa6440d9896&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='161239'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.O46aa6441949bc&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00197 at EcoCyc]
<pre>MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK PIQKGQTLFK
AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG FDAIGSGHHP SFAQALETSM
VCEIPFETLD DLSGKMPNLR QQMMRLMSGE IKGDQDMILL LSKKNAEERL AAFIYNLSRR
FAQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENNDALA
QLAGHTRNVA</pre>
|-
!{{table heading style}} |Mol. Wt
|
27.97 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
8.07<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
7450 - 8075 (calc based on 5 Y, 0 W, and 5 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.B46aa64432366a&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='161241'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
Cys 20, Cys23, Cys29 and Cys122
|
These Cys are ligands for a [4Fe-4S] cluster
|
The [4Fe-4S] cluster is required for dimerization and DNA binding. The [4Fe-4S] cluster is oxygen sensitive rendering FNR inactive under aerobic conditions.
[[PMID:12732309]]<ref name=PMID:12732309/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46aa644385681&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='109123'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46a7f6feb5b19&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161242'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa64443b015&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161243'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00197 EcoCyc:PD00197]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A9E5 UniProt:P0A9E5]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00027 PFAM:PF00027]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415850 RefSeq:NP_415850]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P0A9E5 ModBase:P0A9E5]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.P46aa64448d84f&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='109124'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.X46a7f702215da&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0009061_!_anaerobic respiration]][[Category:GO:0005737_!_cytoplasm]][[Category:GO:0016563_!_transcription activator activity]][[Category:Location:cytoplasm]]

fnr:Gene Product(s)

2007-08-07T03:08:28Z

Pjkiley: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|fnr}}{{Tab|Gene|fnr}}{{Tab On|Gene Product(s)|fnr}}{{Tab|Expression|fnr}}{{Tab|Evolution|fnr}}{{Tab|On One Page|fnr}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
Fnr product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional dual regulator, global regulator of anaerobic growth product<ref name='LIB:Riley_2006'/>, B1334 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fnr product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OssA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, transcriptional regulation of aerobic, anaerobic respiration, osmotic balance product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OxrA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
FNR transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa642929c41&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===
FNR is a global regulator, belonging to the CRP superfamily of helix turn helix DNA binding proteins. FNR is active under anaerobic conditions and depending on the location of the binding site, either activates or represses genes. The oxygen sensing function of FNR is mediated by a [4Fe-4S] cluster. The [4Fe-4S] cluster is ligated to Cys20, 23, 29 and 122, is stable anaerobically and promotes FNR dimerization. In the presence of oxygen, the cluster is converted to a [2Fe-2S] cluster decreasing FNR dimerization, DNA binding and inactivating FNR

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='161237'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009061
|
anaerobic respiration
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.Q46aa642a45f7a&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='161238'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
self
|
detectable dimerization requires ligation of the [4Fe-4S] cluster
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.F46aa6440d9896&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='161239'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.O46aa6441949bc&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00197 at EcoCyc]
<pre>MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK PIQKGQTLFK
AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG FDAIGSGHHP SFAQALETSM
VCEIPFETLD DLSGKMPNLR QQMMRLMSGE IKGDQDMILL LSKKNAEERL AAFIYNLSRR
FAQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENNDALA
QLAGHTRNVA</pre>
|-
!{{table heading style}} |Mol. Wt
|
27.97 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
8.07<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
7450 - 8075 (calc based on 5 Y, 0 W, and 5 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.B46aa64432366a&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='161241'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
Cys 20, Cys23, Cys29 and Cys122
|
These Cys are ligands for a [4Fe-4S] cluster
|
The [4Fe-4S] cluster is required for dimerization and DNA binding. The [4Fe-4S] cluster is oxygen sensitive rendering FNR inactive under aerobic conditions.
[[PMID:12732309]]<ref name=PMID:12732309/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46aa644385681&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='109123'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46a7f6feb5b19&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161242'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa64443b015&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161243'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00197 EcoCyc:PD00197]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A9E5 UniProt:P0A9E5]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00027 PFAM:PF00027]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415850 RefSeq:NP_415850]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P0A9E5 ModBase:P0A9E5]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.P46aa64448d84f&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='109124'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.X46a7f702215da&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0009061_!_anaerobic respiration]][[Category:GO:0005737_!_cytoplasm]][[Category:GO:0016563_!_transcription activator activity]][[Category:Location:cytoplasm]]

fnr:Gene Product(s)

2007-08-07T02:54:32Z

Pjkiley: edited by Pjkiley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|fnr}}{{Tab|Gene|fnr}}{{Tab On|Gene Product(s)|fnr}}{{Tab|Expression|fnr}}{{Tab|Evolution|fnr}}{{Tab|On One Page|fnr}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
Fnr product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional dual regulator, global regulator of anaerobic growth product<ref name='LIB:Riley_2006'/>, B1334 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fnr product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OssA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, transcriptional regulation of aerobic, anaerobic respiration, osmotic balance product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OxrA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
FNR transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa642929c41&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='161237'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009061
|
anaerobic respiration
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.Q46aa642a45f7a&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='161238'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
self
|
detectable dimerization requires ligation of the [4Fe-4S] cluster
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.F46aa6440d9896&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='161239'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.O46aa6441949bc&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00197 at EcoCyc]
<pre>MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK PIQKGQTLFK
AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG FDAIGSGHHP SFAQALETSM
VCEIPFETLD DLSGKMPNLR QQMMRLMSGE IKGDQDMILL LSKKNAEERL AAFIYNLSRR
FAQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENNDALA
QLAGHTRNVA</pre>
|-
!{{table heading style}} |Mol. Wt
|
27.97 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
8.07<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
7450 - 8075 (calc based on 5 Y, 0 W, and 5 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.B46aa64432366a&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='161241'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
Cys 20, Cys23, Cys29 and Cys122
|
These Cys are ligands for a [4Fe-4S] cluster
|
The [4Fe-4S] cluster is required for dimerization and DNA binding. The [4Fe-4S] cluster is oxygen sensitive rendering FNR inactive under aerobic conditions.
[[PMID:12732309]]<ref name=PMID:12732309/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46aa644385681&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='109123'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46a7f6feb5b19&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161242'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa64443b015&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161243'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00197 EcoCyc:PD00197]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A9E5 UniProt:P0A9E5]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00027 PFAM:PF00027]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415850 RefSeq:NP_415850]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P0A9E5 ModBase:P0A9E5]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.P46aa64448d84f&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='109124'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.X46a7f702215da&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0009061_!_anaerobic respiration]][[Category:GO:0005737_!_cytoplasm]][[Category:GO:0016563_!_transcription activator activity]][[Category:Location:cytoplasm]]

PMID:12732309

2007-08-06T15:34:50Z

Pjkiley: New PMID: Page!

<protect>
{{RightTOC}}

 '''Kiley, PJ and Beinert, H''' (2003) The role of Fe-S proteins in sensing and regulation in bacteria.''Curr. Opin. Microbiol.'' '''6''':181-5

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || Fe-S clusters are key to the sensing and transcription functions of three transcription factors, FNR, IscR and SoxR. All three proteins were discovered in Escherichia coli but experimental data and bioinformatic predictions suggest that homologs of these proteins exist in other bacterial species, highlighting the widespread nature of Fe-S-dependent regulatory networks. In addition, the nearly ubiquitous citric acid cycle enzyme, aconitase, plays a role in translational regulation in E. coli and Bacillus subtilis when it loses its Fe-S cluster. Although these regulatory proteins have the common feature of containing an Fe-S cluster, they differ in the physiological signals that they respond to. Therefore, these regulatory factors provide insights into the chemical versatility of Fe-S clusters.
</noinclude>
|-
|{{TableHeadingColor}} nowrap |'''Links''' || [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12732309 PubMed]
|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{|class = 'sortable' {{Prettytable}} id='220135'
|- {{table heading style}}
!Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.0.I46b73f99deb68&page=0&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==References==
{{RefHelp}}
<references/>

fnr:Gene Product(s)

2007-08-06T15:34:27Z

Pjkiley: edited by Pjkiley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|fnr}}{{Tab|Gene|fnr}}{{Tab On|Gene Product(s)|fnr}}{{Tab|Expression|fnr}}{{Tab|Evolution|fnr}}{{Tab|On One Page|fnr}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
Fnr product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional dual regulator, global regulator of anaerobic growth product<ref name='LIB:Riley_2006'/>, B1334 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fnr product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OssA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NirA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, transcriptional regulation of aerobic, anaerobic respiration, osmotic balance product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OxrA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
FNR transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa642929c41&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='161237'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009061
|
anaerobic respiration
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.Q46aa642a45f7a&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='161238'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.F46aa6440d9896&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='161239'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.O46aa6441949bc&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00197 at EcoCyc]
<pre>MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK PIQKGQTLFK
AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG FDAIGSGHHP SFAQALETSM
VCEIPFETLD DLSGKMPNLR QQMMRLMSGE IKGDQDMILL LSKKNAEERL AAFIYNLSRR
FAQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENNDALA
QLAGHTRNVA</pre>
|-
!{{table heading style}} |Mol. Wt
|
27.97 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
8.07<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
7450 - 8075 (calc based on 5 Y, 0 W, and 5 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.B46aa64432366a&page=22654&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='161241'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
Cys 20, Cys23, Cys29 and Cys122
|
These Cys are ligands for a [4Fe-4S] cluster
|
The [4Fe-4S] cluster is required for dimerization and DNA binding. The [4Fe-4S] cluster is oxygen sensitive rendering FNR inactive under aerobic conditions.
[[PMID:12732309]]<ref name=PMID:12732309/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46aa644385681&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='109123'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.V46a7f6feb5b19&page=22654&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161242'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.E46aa64443b015&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='161243'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00197 EcoCyc:PD00197]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A9E5 UniProt:P0A9E5]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00027 PFAM:PF00027]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_415850 RefSeq:NP_415850]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P0A9E5 ModBase:P0A9E5]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.P46aa64448d84f&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='109124'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.22654.X46a7f702215da&page=22654&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0009061_!_anaerobic respiration]][[Category:GO:0005737_!_cytoplasm]][[Category:GO:0016563_!_transcription activator activity]][[Category:Location:cytoplasm]]

iscR:Expression

2007-08-06T15:18:12Z

Pjkiley: edited by Pjkiley via TableEdit

iscR:Gene Product(s)

2007-08-06T15:14:49Z

Pjkiley: edited by Pjkiley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|iscR}}{{Tab|Gene|iscR}}{{Tab On|Gene Product(s)|iscR}}{{Tab|Expression|iscR}}{{Tab|Evolution|iscR}}{{Tab|On One Page|iscR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
IscR product
|

|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor product<ref name='LIB:Riley_2006'/>, B2531 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, IscR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YfhP product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|

|-
!{{table heading style}} |Product description
|
IscR transcriptional regulator<ref name='LIB:EcoCyc10.6'/>; IscR transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>

|
DNA binding and transcription regulation has been shown in vitro
[[PMID:16677314]]<ref name=PMID:16677314/>
|-
!{{table heading style}} |EC number (for enzymes)
|
*
|

|-
|colspan='3'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.R46aaadd5541f7&page=25342&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='170066'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.P46aaadd66413a&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='170067'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.E46aaaddde596b&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='115354'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.O46a84658af2b7&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=G7326-MONOMER at EcoCyc]
<pre>MRLTSKGRYA VTAMLDVALN SEAGPVPLAD ISERQGISLS YLEQLFSRLR KNGLVSSVRG
PGGGYLLGKD ASSIAVGEVI SAVDESVDAT RCQGKGGCQG GDKCLTHALW RDLSDRLTGF
LNNITLGELV NNQEVLDVSG RQHTHDAPRT RTQDAIDVKL RA</pre>
|-
!{{table heading style}} |Mol. Wt
|
17.34 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|

|-
!{{table heading style}} |Extinction coefficient
|
9970 - 10345 (calc based on 3 Y, 1 W, and 3 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.I46aaaddfcde5d&page=25342&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='170069'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
C(92)QGKGGC(98)QGGDKC(104)
|
Cys 92, Cys 98, Cys 104 are ligands to a [2Fe-2S] cluster
|
The [2Fe-2S] cluster is required for the function of IscR at only some of its target promoters.
[[PMID:11742080]]<ref name=PMID:11742080/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Z46aaade04887c&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='115355'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Q46a8465a530f5&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='170070'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.U46aaade11160d&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='170071'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7326-MONOMER EcoCyc:G7326-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0AGK8 UniProt:P0AGK8]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02082 PFAM:PF02082]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_417026 RefSeq:NP_417026]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P0AGK8 ModBase:P0AGK8]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.M46aaade16f2b2&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='115356'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Y46a8465dc1295&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0016563_!_transcription activator activity]]

PMID:11742080

2007-08-06T15:05:51Z

Pjkiley: New PMID: Page!

<protect>
{{RightTOC}}

 '''Schwartz, CJ, Giel, JL, Patschkowski, T, Luther, C, Ruzicka, FJ, Beinert, H and Kiley, PJ''' (2001) IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins.''Proc. Natl. Acad. Sci. U.S.A.'' '''98''':14895-900

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || IscR (iron-sulfur cluster regulator) is encoded by an ORF located immediately upstream of genes coding for the Escherichia coli Fe-S cluster assembly proteins, IscS, IscU, and IscA. IscR shares amino acid similarity with MarA, a member of the MarA/SoxS/Rob family of transcription factors. In this study, we found that IscR functions as a repressor of the iscRSUA operon, because strains deleted for iscR have increased expression of this operon. In addition, in vitro transcription reactions established a direct role for IscR in repression of the iscR promoter. Analysis of IscR by electron paramagnetic resonance showed that the anaerobically isolated protein contains a [2Fe-2S](1+) cluster. The Fe-S cluster appears to be important for IscR function, because repression of iscR expression is significantly reduced in strains containing null mutations of the Fe-S cluster assembly genes iscS or hscA. The finding that IscR activity is decreased in strain backgrounds in which Fe-S cluster assembly is impaired suggests that this protein may be part of a novel autoregulatory mechanism that senses the Fe-S cluster assembly status of cells.
</noinclude>
|-
|{{TableHeadingColor}} nowrap |'''Links''' || [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11742080 PubMed]
|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{|class = 'sortable' {{Prettytable}} id='220133'
|- {{table heading style}}
!Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.0.U46b738cee6f5e&page=0&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==References==
{{RefHelp}}
<references/>

iscR:Gene Product(s)

2007-08-06T15:05:33Z

Pjkiley: edited by Pjkiley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|iscR}}{{Tab|Gene|iscR}}{{Tab On|Gene Product(s)|iscR}}{{Tab|Expression|iscR}}{{Tab|Evolution|iscR}}{{Tab|On One Page|iscR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
IscR product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor product<ref name='LIB:Riley_2006'/>, B2531 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, IscR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YfhP product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
IscR transcriptional regulator<ref name='LIB:EcoCyc10.6'/>; IscR transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.R46aaadd5541f7&page=25342&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='170066'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.P46aaadd66413a&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='170067'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.E46aaaddde596b&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='115354'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.O46a84658af2b7&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=G7326-MONOMER at EcoCyc]
<pre>MRLTSKGRYA VTAMLDVALN SEAGPVPLAD ISERQGISLS YLEQLFSRLR KNGLVSSVRG
PGGGYLLGKD ASSIAVGEVI SAVDESVDAT RCQGKGGCQG GDKCLTHALW RDLSDRLTGF
LNNITLGELV NNQEVLDVSG RQHTHDAPRT RTQDAIDVKL RA</pre>
|-
!{{table heading style}} |Mol. Wt
|
17.34 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|

|-
!{{table heading style}} |Extinction coefficient
|
9970 - 10345 (calc based on 3 Y, 1 W, and 3 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.I46aaaddfcde5d&page=25342&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='170069'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
C(92)QGKGGC(98)QGGDKC(104)
|
Cys 92, Cys 98, Cys 104 are ligands to a [2Fe-2S] cluster
|
The [2Fe-2S] cluster is required for the function of IscR at only some of its target promoters.
[[PMID:11742080]]<ref name=PMID:11742080/>
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Z46aaade04887c&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='115355'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Q46a8465a530f5&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='170070'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.U46aaade11160d&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='170071'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7326-MONOMER EcoCyc:G7326-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0AGK8 UniProt:P0AGK8]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02082 PFAM:PF02082]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_417026 RefSeq:NP_417026]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P0AGK8 ModBase:P0AGK8]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.M46aaade16f2b2&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='115356'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Y46a8465dc1295&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0016563_!_transcription activator activity]]

iscR:Gene Product(s)

2007-08-06T14:59:03Z

Pjkiley: edited by Pjkiley via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|iscR}}{{Tab|Gene|iscR}}{{Tab On|Gene Product(s)|iscR}}{{Tab|Expression|iscR}}{{Tab|Evolution|iscR}}{{Tab|On One Page|iscR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
IscR product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor product<ref name='LIB:Riley_2006'/>, B2531 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, IscR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YfhP product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
IscR transcriptional regulator<ref name='LIB:EcoCyc10.6'/>; IscR transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.R46aaadd5541f7&page=25342&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='170066'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016563
|
transcription activator activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.P46aaadd66413a&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='170067'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.E46aaaddde596b&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

==Localization==


{|class = 'sortable' {{Prettytable}} id='115354'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.O46a84658af2b7&page=25342&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=G7326-MONOMER at EcoCyc]
<pre>MRLTSKGRYA VTAMLDVALN SEAGPVPLAD ISERQGISLS YLEQLFSRLR KNGLVSSVRG
PGGGYLLGKD ASSIAVGEVI SAVDESVDAT RCQGKGGCQG GDKCLTHALW RDLSDRLTGF
LNNITLGELV NNQEVLDVSG RQHTHDAPRT RTQDAIDVKL RA</pre>
|-
!{{table heading style}} |Mol. Wt
|
17.34 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|

|-
!{{table heading style}} |Extinction coefficient
|
9970 - 10345 (calc based on 3 Y, 1 W, and 3 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.I46aaaddfcde5d&page=25342&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='170069'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-
|
Motif
|
C(92)QGKGGC(98)QGGDKC(104)
|
Cys 92, Cys 98, Cys 104 are ligands to a [2Fe-2S] cluster
|
The [2Fe-2S] cluster is required for the function of IscR at only some of its target promoters.
|-class='sortbottom'
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<big>'''Structure'''</big>


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!Structure Type!!Organism!!Accession!!Residues covered!!Notes
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</protect>
===Notes===

==Gene Product Resources==
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!Resource type!!Source!!Notes/Reference
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===Notes===

==Accessions in Other Databases==
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{|class = 'sortable' {{Prettytable}} id='170071'
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!Database!!Accession!!Notes
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7326-MONOMER EcoCyc:G7326-MONOMER]
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0AGK8 UniProt:P0AGK8]
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|-
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[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
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[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02082 PFAM:PF02082]
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|-
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
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[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_417026 RefSeq:NP_417026]
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|-
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[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
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[http://salilab.org/modbase/searchbyid?databaseID=P0AGK8 ModBase:P0AGK8]
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{{Product_accessions_help}}
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===Notes===

==Links==
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!Name!!URL!!Comments
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|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25342.Y46a8465dc1295&page=25342&pagename={{FULLPAGENAMEE}} edit table] || ||
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{{Links_help}}

<noinclude>
==References==
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{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
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[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0016563_!_transcription activator activity]]

PMID:16677314

2007-08-06T04:15:04Z

Pjkiley: New PMID: Page!

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 '''Giel, JL, Rodionov, D, Liu, M, Blattner, FR and Kiley, PJ''' (2006) IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O2-regulated genes in Escherichia coli.''Mol. Microbiol.'' '''60''':1058-75

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|{{TableHeadingColor}} |'''Abstract''' || IscR is an iron-sulphur (Fe-S) cluster-containing transcription factor that represses transcription of the operon containing its own gene and the iscSUA-hscBA-fdx genes, whose products are involved in Fe-S cluster biogenesis. In this study, global transcriptional profiling of Escherichia coli IscR(+) and IscR(-) strains grown under aerobic and anaerobic conditions indicated that 40 genes in 20 predicted operons were regulated by IscR. DNase I footprinting and/or in vitro transcription reactions identified seven new promoters under direct IscR control. Among these were genes encoding known or proposed functions in Fe-S cluster biogenesis (sufABCDSE, yadR and yhgI) and Fe-S cluster-containing anaerobic respiratory enzymes (hyaABCDEF, hybOABCDEFG and napFDAGHBC). The finding that IscR repressed expression of the hyaA, hybO and napF promoters specifically under aerobic growth conditions suggests a new mechanism to explain their upregulation under anaerobic growth conditions. Phylogenetic footprinting of the DNase I protected regions of seven promoters implies that there are at least two different classes of IscR binding sites conserved among many bacteria. The findings presented here indicate a more general role of IscR in the regulation of Fe-S cluster biogenesis and that IscR contributes to the O(2) regulation of several promoters controlling the expression of anaerobic Fe-S proteins.
</noinclude>
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|{{TableHeadingColor}} nowrap |'''Links''' || [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16677314 PubMed]
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</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{|class = 'sortable' {{Prettytable}} id='220132'
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!Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status
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</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==References==
{{RefHelp}}
<references/>

ydiU:Expression

2007-08-06T04:14:32Z

Pjkiley: edited by Pjkiley via TableEdit