EcoliWiki - User contributions [en]

trpR:Gene Product(s)

2007-11-08T19:50:55Z

Jheyrman: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|trpR}}{{Tab|Gene|trpR}}{{Tab On|Gene Product(s)|trpR}}{{Tab|Expression|trpR}}{{Tab|Evolution|trpR}}{{Tab|On One Page|trpR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
TrpR product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor, tryptophan-binding product<ref name='LIB:Riley_2006'/>, B4393 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RtrY product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TrpR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, regulator for trp operon and aroH; trp aporepressor product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
TrpR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of ; [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.E46ab3211524fa&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='184510'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0000162
|
tryptophan biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab32134d6b7&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='184511'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]
|
could be indirect
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]
|
could be indirect
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab3225bb3e5&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

''trpR55'' is synonymous with ''trpR2,'' as studied by Yanofsky, et al, in 1984. <ref>http://cgsc2.biology.yale.edu/Mutation.php?ID=4525</ref>

''trpR2'' acts as a frameshift mutation within the ''trp'' repressor. As a result, the repressor remains inactive and is unable to bind to the operator of the ''trp'' operon, allowing transcription on the trp operon to proceed with tryptophan synthesis, instead of inhibiting production as it normally would in high levels of tryptophan.

''trpR2'' does not target a specific functional repressor, since levels of ''trp'' enzymes in strains with ''trpR2'' mutations do not differ from levels found within strains undergoing ''trpR'' amber and ''trpR'' deletion mutations. <ref name='PMID:6233264'/>

==Localization==


{|class = 'sortable' {{Prettytable}} id='184512'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.F46ab3227a8d24&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

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===Notes===

==Structure and Physical Properties==
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<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00423 at EcoCyc]
<pre>MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD</pre>
|-
!{{table heading style}} |Mol. Wt
|
12.36 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
5.39<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
13980 (calc based on 2 Y, 2 W, and 0 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab3228dbb58&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='184514'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab322963224&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='184515'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRO 1TRO] CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RCS 1RCS] NMR STUDY OF TRP REPRESSOR-OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MI7 1MI7] Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CO0 1CO0] NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1P6Z 1P6Z] E. Coli Trp Apo-Repressor, Monoclinic Crystal Form
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3WRP 3WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|

|

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2WRP 2WRP]
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRT 1WRT] NMR STUDY OF APO TRP REPRESSOR
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRS 1WRS] NMR STUDY OF HOLO TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRP 1WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRR 1TRR] TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG 1JHG] TRP REPRESSOR MUTANT V58I
|

|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.Q46ab3229ce97b&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || ||
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</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184516'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.P46ab3235e24a1&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
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===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184517'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00423 EcoCyc:PD00423]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A881 UniProt:P0A881]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01371 PFAM:PF01371]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418810 RefSeq:NP_418810]
|

|-
|
[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG PDB:1JHG]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.L46ab3236552b3&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
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{{Product_accessions_help}}
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===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184518'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.W46ab323a07943&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0000162_!_tryptophan biosynthetic process]][[Category:GO:0005737_!_cytoplasm]][[Category:Complex:TrpR transcriptional repressor]][[Category:Complex:TrpR-Tryptophan transcriptional repressor]][[Category:Products with structures in PDB]]

metB:Gene Product(s)

2007-11-08T19:50:24Z

Jheyrman: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|metB}}{{Tab|Gene|metB}}{{Tab On|Gene Product(s)|metB}}{{Tab|Expression|metB}}{{Tab|Evolution|metB}}{{Tab|On One Page|metB}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
MetB product
|-
!{{table heading style}} |Synonyms
|
cystathionine gamma-synthase, PLP-dependent product<ref name='LIB:Riley_2006'/>, B3939 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MetB product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
MetB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of ; [[:Category:Complex:O-SUCCHOMOSERLYASE-CPLX|O-SUCCHOMOSERLYASE-CPLX]]<ref name='LIB:EcoCyc10.6'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
** [http://www.brenda.uni-koeln.de/php/result_flat.php4?ecno=2.5.1.48 2.5.1.48]<ref name='LIB:Riley_2006'/>
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.K46ab0f642b49f&page=28520&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='180283'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009063
|
amino acid catabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009086
|
methionine biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.G46ab0f65b0735&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='180284'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
Subunits of [[:Category:Complex:O-SUCCHOMOSERLYASE-CPLX|O-SUCCHOMOSERLYASE-CPLX]]
|
could be indirect
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.N46ab0f7bb6241&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

''metB1'' is a mutant brought about by X-ray mutagenesis and is most likely a deletion mutation.

The ''metB1'' mutation causes a requirement for methionine and produces no enzymatic activity. <ref name='PMID:2687097'/>

==Localization==


{|class = 'sortable' {{Prettytable}} id='119798'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.Q46a8976fbf72d&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=O-SUCCHOMOSERLYASE-MONOMER at EcoCyc]
<pre>MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNE PRAHDYSRRG NPTRDVVQRA
LAELEGGAGA VLTNTGMSAI HLVTTVFLKP GDLLVAPHDC YGGSYRLFDS LAKRGCYRVL
FVDQGDEQAL RAALAEKPKL VLVESPSNPL LRVVDIAKIC HLAREVGAVS VVDNTFLSPA
LQNPLALGAD LVLHSCTKYL NGHSDVVAGV VIAKDPDVVT ELAWWANNIG VTGGAFDSYL
LLRGLRTLVP RMELAQRNAQ AIVKYLQTQP LVKKLYHPSL PENQGHEIAA RQQKGFGAML
SFELDGDEQT LRRFLGGLSL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL
RISTGIEDGE DLIADLENGF RAANKG</pre>
|-
!{{table heading style}} |Mol. Wt
|
41.55 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
6.43<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
25900 - 26525 (calc based on 10 Y, 2 W, and 5 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.M46ab0f7e4f72b&page=28520&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='180286'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.B46ab0f7ec82b7&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='119799'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.K46a897715f47c&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='180287'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.U46ab0f7fa2748&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='180288'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=O-SUCCHOMOSERLYASE-MONOMER EcoCyc:O-SUCCHOMOSERLYASE-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P00935 UniProt:P00935]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01053 PFAM:PF01053]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418374 RefSeq:NP_418374]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P00935 ModBase:P00935]
|

|-class='sortbottom'
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{{Product_accessions_help}}
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===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='119800'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.L46a89774cbc81&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0009063_!_amino acid catabolic process]][[Category:GO:0009086_!_methionine biosynthetic process]][[Category:Complex:O-SUCCHOMOSERLYASE-CPLX]]

metB:Gene Product(s)

2007-11-08T18:18:47Z

Jheyrman: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|metB}}{{Tab|Gene|metB}}{{Tab On|Gene Product(s)|metB}}{{Tab|Expression|metB}}{{Tab|Evolution|metB}}{{Tab|On One Page|metB}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
MetB product
|-
!{{table heading style}} |Synonyms
|
cystathionine gamma-synthase, PLP-dependent product<ref name='LIB:Riley_2006'/>, B3939 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MetB product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
MetB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of ; [[:Category:Complex:O-SUCCHOMOSERLYASE-CPLX|O-SUCCHOMOSERLYASE-CPLX]]<ref name='LIB:EcoCyc10.6'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
** [http://www.brenda.uni-koeln.de/php/result_flat.php4?ecno=2.5.1.48 2.5.1.48]<ref name='LIB:Riley_2006'/>
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.K46ab0f642b49f&page=28520&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='180283'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009063
|
amino acid catabolic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0009086
|
methionine biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.G46ab0f65b0735&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='180284'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
Subunits of [[:Category:Complex:O-SUCCHOMOSERLYASE-CPLX|O-SUCCHOMOSERLYASE-CPLX]]
|
could be indirect
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.N46ab0f7bb6241&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

''metB1'' is a mutant brought about by X-ray mutagenesis and is most likely a deletion mutation.

The ''metB1'' mutation causes a requirement for methionine and produces no enzymatic activity. <ref name='PMID:2687097'/>

Last updated 11/8/07 by user JHeyrman.

==Localization==


{|class = 'sortable' {{Prettytable}} id='119798'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.Q46a8976fbf72d&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=O-SUCCHOMOSERLYASE-MONOMER at EcoCyc]
<pre>MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNE PRAHDYSRRG NPTRDVVQRA
LAELEGGAGA VLTNTGMSAI HLVTTVFLKP GDLLVAPHDC YGGSYRLFDS LAKRGCYRVL
FVDQGDEQAL RAALAEKPKL VLVESPSNPL LRVVDIAKIC HLAREVGAVS VVDNTFLSPA
LQNPLALGAD LVLHSCTKYL NGHSDVVAGV VIAKDPDVVT ELAWWANNIG VTGGAFDSYL
LLRGLRTLVP RMELAQRNAQ AIVKYLQTQP LVKKLYHPSL PENQGHEIAA RQQKGFGAML
SFELDGDEQT LRRFLGGLSL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL
RISTGIEDGE DLIADLENGF RAANKG</pre>
|-
!{{table heading style}} |Mol. Wt
|
41.55 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
6.43<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
25900 - 26525 (calc based on 10 Y, 2 W, and 5 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.M46ab0f7e4f72b&page=28520&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='180286'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.B46ab0f7ec82b7&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='119799'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.K46a897715f47c&page=28520&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='180287'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.U46ab0f7fa2748&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='180288'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=O-SUCCHOMOSERLYASE-MONOMER EcoCyc:O-SUCCHOMOSERLYASE-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P00935 UniProt:P00935]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01053 PFAM:PF01053]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418374 RefSeq:NP_418374]
|

|-
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
|
[http://salilab.org/modbase/searchbyid?databaseID=P00935 ModBase:P00935]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.S46ab0f8013cab&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='119800'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.28520.L46a89774cbc81&page=28520&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0009063_!_amino acid catabolic process]][[Category:GO:0009086_!_methionine biosynthetic process]][[Category:Complex:O-SUCCHOMOSERLYASE-CPLX]]

trpR:Gene Product(s)

2007-11-08T17:26:05Z

Jheyrman: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|trpR}}{{Tab|Gene|trpR}}{{Tab On|Gene Product(s)|trpR}}{{Tab|Expression|trpR}}{{Tab|Evolution|trpR}}{{Tab|On One Page|trpR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
TrpR product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor, tryptophan-binding product<ref name='LIB:Riley_2006'/>, B4393 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RtrY product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TrpR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, regulator for trp operon and aroH; trp aporepressor product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
TrpR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of ; [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.E46ab3211524fa&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='184510'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0000162
|
tryptophan biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab32134d6b7&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='184511'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]
|
could be indirect
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]
|
could be indirect
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab3225bb3e5&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

''trpR55'' is synonymous with ''trpR2,'' as studied by Yanofsky, et al, in 1984. <ref>http://cgsc2.biology.yale.edu/Mutation.php?ID=4525</ref>

''trpR2'' acts as a frameshift mutation within the ''trp'' repressor. As a result, the repressor remains inactive and is unable to bind to the operator of the ''trp'' operon, allowing transcription on the trp operon to proceed with tryptophan synthesis, instead of inhibiting production as it normally would in high levels of tryptophan.

''trpR2'' does not target a specific functional repressor, since levels of ''trp'' enzymes in strains with ''trpR2'' mutations do not differ from levels found within strains undergoing ''trpR'' amber and ''trpR'' deletion mutations. <ref name='PMID:6233264'/>

Last updated 11/8/07 by user JHeyrman.

==Localization==


{|class = 'sortable' {{Prettytable}} id='184512'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.F46ab3227a8d24&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00423 at EcoCyc]
<pre>MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD</pre>
|-
!{{table heading style}} |Mol. Wt
|
12.36 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
5.39<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
13980 (calc based on 2 Y, 2 W, and 0 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab3228dbb58&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='184514'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab322963224&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='184515'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRO 1TRO] CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RCS 1RCS] NMR STUDY OF TRP REPRESSOR-OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MI7 1MI7] Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CO0 1CO0] NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1P6Z 1P6Z] E. Coli Trp Apo-Repressor, Monoclinic Crystal Form
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3WRP 3WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|

|

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2WRP 2WRP]
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRT 1WRT] NMR STUDY OF APO TRP REPRESSOR
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRS 1WRS] NMR STUDY OF HOLO TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRP 1WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRR 1TRR] TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG 1JHG] TRP REPRESSOR MUTANT V58I
|

|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.Q46ab3229ce97b&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184516'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.P46ab3235e24a1&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184517'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00423 EcoCyc:PD00423]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A881 UniProt:P0A881]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01371 PFAM:PF01371]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418810 RefSeq:NP_418810]
|

|-
|
[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG PDB:1JHG]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.L46ab3236552b3&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184518'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.W46ab323a07943&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0000162_!_tryptophan biosynthetic process]][[Category:GO:0005737_!_cytoplasm]][[Category:Complex:TrpR transcriptional repressor]][[Category:Complex:TrpR-Tryptophan transcriptional repressor]][[Category:Products with structures in PDB]]

trpR:Gene Product(s)

2007-11-08T17:25:14Z

Jheyrman: /* Notes */

trpR:Gene Product(s)

2007-11-08T17:24:35Z

Jheyrman: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|trpR}}{{Tab|Gene|trpR}}{{Tab On|Gene Product(s)|trpR}}{{Tab|Expression|trpR}}{{Tab|Evolution|trpR}}{{Tab|On One Page|trpR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
TrpR product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor, tryptophan-binding product<ref name='LIB:Riley_2006'/>, B4393 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RtrY product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TrpR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, regulator for trp operon and aroH; trp aporepressor product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
TrpR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of ; [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.E46ab3211524fa&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='184510'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0000162
|
tryptophan biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab32134d6b7&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='184511'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]
|
could be indirect
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]
|
could be indirect
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab3225bb3e5&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

''trpR55'' is synonymous with ''trpR2'' as studied by Yanofsky, et al, in 1984. <ref>http://cgsc2.biology.yale.edu/Mutation.php?ID=4525</ref>

''trpR2'' acts as a frameshift mutation within the ''trp'' repressor. As a result, the repressor remains inactive and is unable to bind to the operator of the ''trp'' operon, allowing transcription on the trp operon to proceed with tryptophan synthesis, instead of inhibiting production as it normally would in high levels of tryptophan.

''trpR2'' does not target a specific functional repressor, since levels of ''trp'' enzymes in strains with ''trpR2'' mutations do not differ from levels found within strains undergoing ''trpR'' amber and ''trpR'' deletion mutations. <ref name='PMID:6233264'/>

==Localization==


{|class = 'sortable' {{Prettytable}} id='184512'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.F46ab3227a8d24&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00423 at EcoCyc]
<pre>MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD</pre>
|-
!{{table heading style}} |Mol. Wt
|
12.36 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
5.39<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
13980 (calc based on 2 Y, 2 W, and 0 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab3228dbb58&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='184514'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab322963224&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='184515'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRO 1TRO] CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RCS 1RCS] NMR STUDY OF TRP REPRESSOR-OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MI7 1MI7] Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CO0 1CO0] NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1P6Z 1P6Z] E. Coli Trp Apo-Repressor, Monoclinic Crystal Form
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3WRP 3WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|

|

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2WRP 2WRP]
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRT 1WRT] NMR STUDY OF APO TRP REPRESSOR
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRS 1WRS] NMR STUDY OF HOLO TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRP 1WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRR 1TRR] TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG 1JHG] TRP REPRESSOR MUTANT V58I
|

|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.Q46ab3229ce97b&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184516'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.P46ab3235e24a1&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184517'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00423 EcoCyc:PD00423]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A881 UniProt:P0A881]
|

|-
|
[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01371 PFAM:PF01371]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418810 RefSeq:NP_418810]
|

|-
|
[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG PDB:1JHG]
|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.L46ab3236552b3&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_accessions_help}}
<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184518'
|- {{table_heading_style}}
!Name!!URL!!Comments
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.W46ab323a07943&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Links_help}}

<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references/>
__NOTOC__
</noinclude>
===Categories===
{{BacktoTop}}
[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0000162_!_tryptophan biosynthetic process]][[Category:GO:0005737_!_cytoplasm]][[Category:Complex:TrpR transcriptional repressor]][[Category:Complex:TrpR-Tryptophan transcriptional repressor]][[Category:Products with structures in PDB]]

trpR:Gene Product(s)

2007-11-08T16:58:57Z

Jheyrman: /* Notes */

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|trpR}}{{Tab|Gene|trpR}}{{Tab On|Gene Product(s)|trpR}}{{Tab|Expression|trpR}}{{Tab|Evolution|trpR}}{{Tab|On One Page|trpR}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==


{|{{Prettytable}}
|-
!{{table heading style}} |Standard name
|
TrpR product
|-
!{{table heading style}} |Synonyms
|
DNA-binding transcriptional repressor, tryptophan-binding product<ref name='LIB:Riley_2006'/>, B4393 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RtrY product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, TrpR product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, regulator for trp operon and aroH; trp aporepressor product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!{{table heading style}} |Product description
|
TrpR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of ; [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

|-
!{{table heading style}} |EC number (for enzymes)
|
*
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.E46ab3211524fa&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_nomenclature_help}}
<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big>


{|class = 'sortable' {{Prettytable}} id='184510'
|- {{table_heading_style}}
!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006350
|
transcription
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0016564
|
transcription repressor activity
|

|

|

|
F
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0000162
|
tryptophan biosynthetic process
|

|

|

|
P
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-
|

|
GO:0005737
|
cytoplasm
|

|

|

|
C
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.
|
required fields missing
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab32134d6b7&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || || || || || ||
|}

{{Product_GO_help}}

<big>'''Interactions'''</big>


{|class = 'sortable' {{Prettytable}} id='184511'
|- {{table heading style}}
!Partner Type!!Partner!!Notes
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR transcriptional repressor|TrpR transcriptional repressor]]
|
could be indirect
|-
|
Protein
|
Subunits of [[:Category:Complex:TrpR-Tryptophan transcriptional repressor|TrpR-Tryptophan transcriptional repressor]]
|
could be indirect
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.T46ab3225bb3e5&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_interactions_help}}
</protect>
===Notes===

''trpR55'' is synonymous with ''trpR2'' as studied by Yanofsky, et al, in 1984. <ref>http://cgsc2.biology.yale.edu/Mutation.php?ID=4525</ref>

==Localization==


{|class = 'sortable' {{Prettytable}} id='184512'
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.F46ab3227a8d24&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_localization_help}}
<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>


{|{{Prettytable}}
|-
!{{table heading style}} |Sequence
|
[http://biocyc.org/ECOLI/sequence-aa?object=PD00423 at EcoCyc]
<pre>MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD</pre>
|-
!{{table heading style}} |Mol. Wt
|
12.36 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |pI
|
5.39<ref name='LIB:EcoCyc10.6'/>
|-
!{{table heading style}} |Extinction coefficient
|
13980 (calc based on 2 Y, 2 W, and 0 C residues)
|-
|colspan='2'|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab3228dbb58&page=29544&pagename={{FULLPAGENAMEE}} edit table]
|}

{{Product_physical_properties_help}}

<big>'''Domains/Motifs/Modification Sites'''</big>


{|class = 'sortable' {{Prettytable}} id='184514'
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.O46ab322963224&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || ||
|}

{{Product_domains_motifs_help}}

<big>'''Structure'''</big>


{|class = 'sortable' {{Prettytable}} id='184515'
|- {{table heading style}}
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRO 1TRO] CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1RCS 1RCS] NMR STUDY OF TRP REPRESSOR-OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MI7 1MI7] Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1CO0 1CO0] NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1P6Z 1P6Z] E. Coli Trp Apo-Repressor, Monoclinic Crystal Form
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3WRP 3WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|

|

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2WRP 2WRP]
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRT 1WRT] NMR STUDY OF APO TRP REPRESSOR
|

|

|-
|
NMR, 15 STRUCTURES

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRS 1WRS] NMR STUDY OF HOLO TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1WRP 1WRP] FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1TRR 1TRR] TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX
|

|

|-
|
X-RAY DIFFRACTION

|
Escherichia coli

|
[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG 1JHG] TRP REPRESSOR MUTANT V58I
|

|

|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.Q46ab3229ce97b&page=29544&pagename={{FULLPAGENAMEE}} edit table] || || || ||
|}

{{Product_structure_help}}
</protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184516'
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
|-class='sortbottom'
|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.29544.P46ab3235e24a1&page=29544&pagename={{FULLPAGENAMEE}} edit table] || ||
|}

{{Product_resources_help}}
<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}


{|class = 'sortable' {{Prettytable}} id='184517'
|- {{table_heading_style}}
!Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD00423 EcoCyc:PD00423]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.expasy.ch/cgi-bin/sprot-search-ac?P0A881 UniProt:P0A881]
|

|-
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[http://www.sanger.ac.uk/Software/Pfam/ PFAM] ([[PFAM|EcoliWiki Page]])
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[http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01371 PFAM:PF01371]
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|-
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[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418810 RefSeq:NP_418810]
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|-
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[http://www.rcsb.org/pdb PDB] ([[PDB|EcoliWiki Page]])
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[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1JHG PDB:1JHG]
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===Notes===

==Links==
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==References==
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<references/>
__NOTOC__
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===Categories===
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[[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0000162_!_tryptophan biosynthetic process]][[Category:GO:0005737_!_cytoplasm]][[Category:Complex:TrpR transcriptional repressor]][[Category:Complex:TrpR-Tryptophan transcriptional repressor]][[Category:Products with structures in PDB]]