EcoliWiki - User contributions [en]

PMID:20616037

2011-10-21T17:36:35Z

Azweifel: Fill PMID: Page!

{{RightTOC}}
<protect>
 '''Schumann, U, Edwards, MD, Rasmussen, T, Bartlett, W, van West, P and Booth, IR''' (2010) YbdG in Escherichia coli is a threshold-setting mechanosensitive channel with MscM activity.''Proc. Natl. Acad. Sci. U.S.A.'' '''107''':12664-9

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>We describe a mechanosensitive (MS) channel that has mechanosensitive channel of miniconductance (MscM) activity, and displays unique properties with respect to gating. Mechanosensitive channels respond to membrane tension, are ubiquitous from bacteria to man, and exhibit a great diversity in structure and function. These channels protect Bacteria and Archaea against hypoosmotic shock and are critical determinants of shape in chloroplasts. Given the dominant roles played in bacteria by the mechanosensitive channel of small conductance (MscS) and the mechanosensitive channel of large conductance (MscL), the role of the multiple MS channel homologs observed in most organisms remains obscure. Here we demonstrate that a MscS homolog, YbdG, extends the range of hypoosmotic shock that Escherichia coli cells can survive, but its expression level is insufficient to protect against severe shocks. Overexpression of the YbdG protein provides complete protection. Transcription and translation of the ybdG gene are enhanced by osmotic stress consistent with a role for the protein in survival of hypoosmotic shock. Measurement of the conductance of the native channel by standard patch clamp methods was not possible. However, a fully functional YbdG mutant channel, V229A, exhibits a conductance in membrane patches consistent with MscM activity. We find that MscM activities arise from more than one gene product because ybdG deletion mutants still exhibit an occasional MscM-like conductance. We propose that ybdG encodes a low-abundance MscM-type MS channel, which in cells relieves low levels of membrane tension, obviating the need to activate the major MS channels, MscS and MscL.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20616037 PubMed]
Online version:[http://dx.doi.org/10.1073/pnas.1001405107 10.1073/pnas.1001405107]
|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{| id="S4ea1ada3c0aba" class=" tableEdit GO_table_reference dataTable"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.180718.S4ea1ada3c0aba&page=180718&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==See also==

==References==
{{RefHelp}}
<references/>

PMID:20616037

2011-10-21T17:36:35Z

Azweifel: New PMID: Page!

mscM:Gene Product(s)

2011-10-21T17:35:55Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|mscM}}{{Tab|Gene|mscM}}{{Tab On|Gene Product(s)|mscM}}{{Tab|Expression|mscM}}{{Tab|Evolution|mscM}}{{Tab|On One Page|mscM}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="Z46aa373ab7d41" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
MscM
|-
!align=left {{table heading style}} |Synonyms
||
''predicted mechanosensitive channel<ref name='LIB:Riley_2006'/>, B0577<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbdG<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0569, JW0566, ybdG, b0577''
|-
!align=left {{table heading style}} |Product description
||
putative transport protein<ref name='LIB:EcoCyc10.6'/>; predicted mechanosensitive channel<ref name='LIB:EcoCyc11.1'/>

Putative mechanosensitive channel protein, function unknown<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="Q46aa373bae8b5" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006685
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011066
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0472
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9909
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0055085
|
transmembrane transport
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006685
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006970
|
response to osmotic stress
|
PMID:20616037
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:kefA
EcoliWiki:mscL
EcoliWiki:mscS

|
P
|
Figure 3
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20847.Q46aa373bae8b5&page=20847&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="B46aa373e94be5" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
groL 
|

|
PMID:16606699
|
Experiment(s):EBI-1137222 
|-
|
Protein
|
clpB 
|

|
PMID:16606699
|
Experiment(s):EBI-1137222 
|-
|
Protein
|
lon 
|

|
PMID:16606699
|
Experiment(s):EBI-1137222 

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="E46a7c8b8b44c0" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 5 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20847.E46a7c8b8b44c0&page=20847&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="G46aa374054bc3" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Name
||

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6323-MONOMER at EcoCyc]
<pre>MQDLISQVED LAGIEIDHTT SMVMIFGIIF LTAVVVHIIL HWVVLRTFEK RAIASSRLWL
QIITQNKLFH RLAFTLQGII VNIQAVFWLQ KGTEAADILT TCAQLWIMMY ALLSVFSLLD
VILNLAQKFP AASQLPLKGI FQGIKLIGAI LVGILMISLL IGQSPAILIS GLGAMAAVLM
LVFKDPILGL VAGIQLSAND MLKLGDWLEM PKYGADGAVI DIGLTTVKVR NWDNTITTIP
TWSLVSDSFK NWSGMSASGG RRIKRSISID VTSIRFLDED EMQRLNKAHL LKPYLTSRHQ
EINEWNRQQG STESVLNLRR MTNIGTFRAY LNEYLRNHPR IRKDMTLMVR QLAPGDNGLP
LEIYAFTNTV VWLEYESIQA DIFDHIFAIV EEFGLRLHQS PTGNDIRSLA GAFKQ</pre>
|-
!align=left {{table heading style}} |Length
||
415
|-
!align=left {{table heading style}} |Mol. Wt
||
46.604 kDa
|-
!align=left {{table heading style}} |pI
||
8.3 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
65,430 - 65,555 (calc based on 7 Y, 10 W, and 1 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20847.G46aa374054bc3&page=20847&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="Z46aa3740aeb70" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
142..330
|
[http://pfam.janelia.org/family/PF00924 PF00924 Mechanosensitive ion channel]
|

|
PMID:19920124
|-
|
Domain
|
305..398
|
[http://pfam.janelia.org/family/PF00924 PF00924 Mechanosensitive ion channel]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|mscM}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="X46a7c8ba66a6c" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ybdG
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P0AAT4 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20847.X46a7c8ba66a6c&page=20847&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="H46aa374150831" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20847.H46aa374150831&page=20847&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="N46aa37419af54" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16128560 GI:16128560]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_415109.1 GeneID:946243]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWiki Page]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0001978&formSubmitReturn=1 ASAP:ABE-0001978]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0AAT4 UniProtKB/Swiss-Prot:P0AAT4]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6323 ECOCYC:G6323]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG12620 EcoGene:EG12620]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/gene?term=946243 GeneID:946243]
|
Escherichia coli str. K-12 substr. MG1655

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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Z46a7c8bdc839e" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20847.Z46a7c8bdc839e&page=20847&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

lacZ:Quickview

2011-08-15T20:12:03Z

Azweifel: /* Notes */

lacZ:Quickview

2011-08-15T20:11:18Z

Azweifel: /* Notes */

PMID:3283125

2011-08-04T02:46:36Z

Azweifel: Fill PMID: Page!

{{RightTOC}}
<protect>
 '''Maki, S and Kornberg, A''' (1988) DNA polymerase III holoenzyme of Escherichia coli. I. Purification and distinctive functions of subunits tau and gamma, the dnaZX gene products.''J. Biol. Chem.'' '''263''':6547-54

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>Escherichia coli dnaZX, the gene which when mutant blocks DNA chain elongation, was cloned into a lambda PL promoter-mediated expression vector. In cells carrying this plasmid, the activity that complements a mutant dnaZ extract in replicating a primed single-stranded DNA circle was increased about 20-fold. Two polypeptides of 71 and 52 kDa were overproduced. Upon fractionation, two complementing activities were purified to homogeneity and proved to be the 71- and 52-kDa polypeptides. Immunoassays revealed their respective identities with the tau and gamma subunits of DNA polymerase III holoenzyme. The N-terminal amino acid sequences of the first 12 residues were identical in both subunits, as were their molar specific activities in dnaZ complementation. Thus, the tau subunit complements the defect in the mutant holoenzyme from the dnaZts strain as efficiently as does the gamma subunit. Inasmuch as the 71-kDa subunit (tau) can also overcome the enzymatic defect in a dnaX mutant strain, this polypeptide has dual replication functions, only one of which can be performed by the gamma subunit. Availability of pure tau and gamma subunits for study has provided the basis for proposing an asymmetry in the structure and function of a dimeric DNA polymerase III holoenzyme.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3283125 PubMed]

|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{| id="R4e3a080c46f99" class=" tableEdit GO_table_reference dataTable"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.179402.R4e3a080c46f99&page=179402&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==See also==

==References==
{{RefHelp}}
<references/>

PMID:3283125

2011-08-04T02:46:36Z

Azweifel: New PMID: Page!

mutS:Gene Product(s)

2011-04-13T21:08:23Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|mutS}}{{Tab|Gene|mutS}}{{Tab On|Gene Product(s)|mutS}}{{Tab|Expression|mutS}}{{Tab|Evolution|mutS}}{{Tab|On One Page|mutS}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="D46aababaf1640" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
MutS
|-
!align=left {{table heading style}} |Synonyms
||
methyl-directed mismatch repair protein<ref name='LIB:Riley_2006'/>, B2733<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Plm<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ant<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fdv<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MutS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
MutS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;

Component of [[:Category:Complex:MutHLS complex, methyl-directed mismatch repair|MutHLS complex, methyl-directed mismatch repair]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Methyl-directed mismatch repair protein; dimeric/tetrameric<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="W46aababc7503a" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0006298
|
mismatch repair
|
PMID:6987663
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
PMID:3014530
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
PMID:2665076
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0016887
|
ATPase activity
|
PMID:10715140
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032300
|
mismatch repair complex
|
PMID:6987663
|
IGI: Inferred from Genetic Interaction
|
UniProtKB:P06722|UniProtKB:P23367
|
C
|
P06722 (MutH)
P23367 (MutL)
|
complete
|-
|

|
GO:0003684
|
damaged DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00096
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00096
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000432
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005748
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007695
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007696
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007860
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007861
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016151
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0067
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00096
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000432
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005748
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007695
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032136
|
adenine/cytosine mispair binding
|
PMID:11237867
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007696
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007860
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007861
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016151
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000432
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR005748
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007695
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007696
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007860
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR007861
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR016151
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006974
|
response to DNA damage stimulus
|
PMID:11967071
|
IEP: Inferred from Expression Pattern
|

|
P
|

|
complete
|-
|

|
GO:0043531
|
ADP binding
|
PMID:11048711
|
IDA: Inferred from Direct Assay
|

|
F
|
Xstal structure
|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
PMID:11048711
|
IDA: Inferred from Direct Assay
|

|
F
|
Xstal structure
|
complete
|-
|

|
GO:0008301
|
DNA bending activity
|
PMID:14634210
|
IDA: Inferred from Direct Assay
|

|
F
|
atomic force microscopy
|
complete
|-
|

|
GO:0006298
|
mismatch repair
|
PMID:14634210
|
IDA: Inferred from Direct Assay
|

|
P
|
Atomic force microscopy
|
complete
|-
|

|
GO:0005524
|
ATP binding
|
PMID:12606120
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0030983
|
mismatched DNA binding
|
PMID:3014530
|
IDA: Inferred from Direct Assay
|

|
F
|
Enzymatic and chemical protection (footprinting) assays
|
complete
|-
|

|
GO:0000018
|
regulation of DNA recombination
|
PMID:2555716
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.25791.W46aababc7503a&page=25791&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| {{Prettytable}} id="T46aabac3cc002" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
Subunits of [[:Category:Complex:MutHLS complex, methyl-directed mismatch repair|MutHLS complex, methyl-directed mismatch repair]]
|

|
PMID:6987663
|
Inferred from genetic interaction
|-
|
Protein
|
tufA 
|

|
PMID:15690043
|
Experiment(s):EBI-886447 
|-
|
Protein
|
galF 
|

|
PMID:16606699
|
Experiment(s):EBI-1143773 
|-
|
Protein
|
baeS 
|

|
PMID:16606699
|
Experiment(s):EBI-1143773 
|-
|
Protein
|
envZ 
|

|
PMID:16606699
|
Experiment(s):EBI-1143773 
|-
|
Protein
|
DnaN: beta sliding clamp subunit of DNA pol III
|

|
PMID:11459978
|
Protein mobility shift during native gel electrophoresis and kinase protection assay.
|-
|
DNA
|
GT mismatches
|

|
PMID:11048711
|
Crystal structure
|-
|
Protein
|
MutL
|

|
PMID:9250691
|
Visualized using EM
|-
|
DNA
|
Heteroduplex DNA
|

|
PMID:9250691
|
Visualized using EM

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="N46a851be1758c" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="R46aabac634eb7" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10625-MONOMER at EcoCyc]
<pre>MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA
SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS
DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY
AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL
LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA
RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR
DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG
QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE
ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA
DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK
ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG
VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR
QALEWIYRLK SLV</pre>
|-
!align=left {{table heading style}} |Length
||
853
|-
!align=left {{table heading style}} |Mol. Wt
||
95.249 kDa
|-
!align=left {{table heading style}} |pI
||
5.4 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
73,230 - 73,980 (calc based on 27 Y, 6 W, and 6 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="N46aabac6a4920" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
11..123
|
[http://pfam.janelia.org/family/PF01624 PF01624 MutS domain I]
|

|
PMID:19920124
|-
|
Domain
|
131..256
|
[http://pfam.janelia.org/family/PF05188 PF05188 MutS domain II]
|

|
PMID:19920124
|-
|
Domain
|
264..564
|
[http://pfam.janelia.org/family/PF05192 PF05192 MutS domain III]
|

|
PMID:19920124
|-
|
Domain
|
428..519
|
[http://pfam.janelia.org/family/PF05190 PF05190 MutS family domain IV]
|

|
PMID:19920124
|-
|
Domain
|
567..799
|
[http://pfam.janelia.org/family/PF00488 PF00488 MutS domain V]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="K46a851bfb0236" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=mutS
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
Analytical ultracentrifugation data suggest that MutS exists as an equilibrating mixture of dimers and tetramers, both of which would be present at physiologically relevant concentrations. Kinetic parameters for ATPase activity and oligomerization are described<ref name='PMID:12829697'/><ref name='PMID:10715140'/>

There are several structure papers for MutS:
*The crystal structure of DNA mismatch repair protein MutS binding to a G-T mismatch<ref name='PMID:11048711'/>
*Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA<ref name='PMID:11048710'/>

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Q46aabac775c2b" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purification protocol
|
from plasmid pMS312
|
PMID:3014530
|-
|
Purification protocol
|
Single-step purification of His6-MutS
|
PMID:8747662

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="B46aabac7d4685" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10625-MONOMER EcoCyc:EG10625-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P23909 UniProt:P23909]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P23909 Pfam:P23909]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_417213 RefSeq:NP_417213]
|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="P46a851c363baa" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]
[[Category:RefGenome_Annotated_Gene]]

mutS:Gene

2011-04-13T21:04:46Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|mutS}}{{Tab On|Gene|mutS}}{{Tab|Gene Product(s)|mutS}}{{Tab|Expression|mutS}}{{Tab|Evolution|mutS}}{{Tab|On One Page|mutS}}{{TabsBottom}}
{|
|- style="background-color:white; border:solid 2px #CCFFFF; text-align:center; white-space: nowrap;"
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Location(s) and DNA Sequence|Location(s) and DNA Sequence]]
|{{Sub}}[[#Sequence Features|Sequence Features]]
|{{Sub}}[[#Alleles and Phenotypes |Alleles and Phenotypes]]
|{{Sub}}[[#Genetic Resources |Genetic Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References |References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude><protect>
==Nomenclature==
{{BacktoTop}}

{{Gene_nomenclature_help}}
{| id="Y46a9e4f168029" class=" tableEdit Gene_nomenclature_table"

|-
!align=left {{table_heading_style}} |Standard name
||
''mutS''
|-
!align=left {{table_heading_style}} |Mnemonic
||
Mutator
|-
!align=left {{table_heading_style}} |Synonyms
||
''ECK2728, b2733, JW2703, fdv, ant, plm''<ref name='LIB:Riley_2006'/>

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.16031.Y46a9e4f168029&page=16031&pagename={{FULLPAGENAMEE}}&type=1&template=Gene_nomenclature_table edit table] ||
|}


</protect>
===Notes===

==Location(s) and DNA Sequence==
{{BacktoTop}}
<protect>

{{Gene_location_help}}
{| id="Z46a9e4f1e731c" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
|-
|
MG1655
|
61.54 minutes 
|
MG1655: 2855115..2857676 <gbrowseImage>
name=NC_000913:2855115..2857676
source=ecoli
preset=GeneLocation
</gbrowseImage>

|
*[http://biocyc.org/ECOLI/NEW-IMAGE?type=LOCUS-POSITION&chromosome=COLI-K12&object=EG10625 EcoCyc]
{{GBrowseLink|ecoli|NC_000913|2854115|2858676|GBrowse(MG1655)}}

|
{{GBrowseFastaLink|ecoli|NC_000913|2855115|2857676|FASTA Dump}}
*[http://biocyc.org/ECOLI/sequence?object=EG10625 EcoCyc Sequence Dump]
|-
|
[[REL606]]
|

|
NC_012967: 2751953..2754514 <gbrowseImage>
name=NC_012967:2751953..2754514
source=REL606
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|REL606|NC_012967|2751953|2754514|GBrowse (REL606)}}
|
{{GBrowseFastaLink|REL606|NC_012967|2751953|2754514|FASTA Dump}}
|-
|
[[BW2952]]
|

|
NC_012759: 2740927..2743488 <gbrowseImage>
name=NC_012759:2740927..2743488
source=BW2952
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|BW2952|012759|2740927|NC_2743488|GBrowse (BW2952)}}
|
{{GBrowseFastaLink|BW2952|012759|2740927|NC_2743488|FASTA Dump}}
|-
|
W3110
|
 
|
W3110: 2855749..2858310 <gbrowseImage>
name=AC_000091:2855749..2858310
source=ecoli_W3110
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|ecoli_W3110|AC_000091|2854749|2859310|GBrowse(W3110)}}
|
{{GBrowseFastaLink|ecoli_W3110|AC_000091|2855749|2858310|FASTA Dump}}
|-
|
[[DH10B]]
|

|
DH10B: 2947657..2950218 <gbrowseImage>
name=NC_010473:2947657..2950218
source=ecoli_DH10B
preset=GeneLocation
</gbrowseImage>

|
{{GBrowseLink|ecoli_DH10B|NC_010473|2942535|2955340|GBrowse(DH10B)}}
|
{{GBrowseFastaLink|ecoli_DH10B|NC_010473|2942535|2955340|FASTA Dump}}

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.16031.Z46a9e4f1e731c&page=16031&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}


</protect>
===Notes===

==Sequence Features==
{{BacktoTop}}

{{Gene_sequence_features_help}}
{| id="Q46a9e4f2a1f43" class=" tableEdit Gene_sequence_features_table"
|- {{table_heading_style}}
!|Feature Type!!Strain!!Genomic Location!!Evidence!!Reference!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.16031.Q46a9e4f2a1f43&page=16031&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_sequence_features_table edit table] || || || || ||
|}


<protect></protect>
====Notes====

==Alleles and Phenotypes==
{{BacktoTop}}

{{Gene_alleles_help}}
{| {{Prettytable}} id="K46a9e4f2e8b0f" class=" tableEdit Gene_allele_table dataTable"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!AA change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments
|-
|
ΔmutS (Keio:JW2703)
|
deletion
|
deletion
|

|

|
PMID:16738554
|
[http://www.shigen.nig.ac.jp/ecoli/strain/keioCollectionQueryAction.do Shigen] [http://cgsc2.biology.yale.edu/Strain.php?ID=108407 CGSC10126]<ref name='LIB:cgsc'/>
|

|-
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?FeatureID=ABE-0008977 mutS::Tn5KAN-I-SceI] (FB20917)
|
Insertion at nt 2340 in Minus orientation
|

|

|

|
PMID:15262929
|
[http://www.genome.wisc.edu/resources/forms/strainrequest.htm E. coli Genome Project:FB20917]
|
contains [[pKD46]]
|-
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?FeatureID=ABE-0008977 mutS::Tn5KAN-I-SceI] (FB20918)
|
Insertion at nt 2340 in Minus orientation
|

|

|

|
PMID:15262929
|
[http://www.genome.wisc.edu/resources/forms/strainrequest.htm E. coli Genome Project:FB20918]
|
does not contain [[pKD46]]
|-
|
''mutS201::Tn5''
|

|

|

|

|

|
[[cgscmutation:7794|CGSC:7794]]
|

|-
|
''mutS215::Tn10''
|

|

|

|

|

|
[[cgscmutation:7797|CGSC:7797]]
|

|-
|
''mutS3''
|

|

|

|

|

|
[[cgscmutation:11134|CGSC:11134]]
|

|-
|
''mutS210''
|

|

|

|

|

|
[[cgscmutation:85420|CGSC:85420]]
|

|-
|
''mutS104::mini-Tn10''
|

|

|

|

|

|
[[cgscmutation:85448|CGSC:85448]]
|

|-
|
''ΔmutS738::kan''
|

|

|

|

|
PMID:16738554
|
[[cgscmutation:101976|CGSC:101976]]
|

|-
|
MutS F596A
|

|
F596A
|

|
* Mildly defective ATPase activity
* Defective MutH activation ''in vitro''
* Moderately elevated mutation and DNA recombination rates ''in vivo''
|
PMID:12606120
|

|

|-
|
MutS H760A
|

|
H760A
|

|
* Mildly defective ATPase activity
* Defective MutH activation ''in vitro''
* Moderately elevated mutation and DNA recombination rates ''in vivo''

|
PMID:12606120
|

|

|-
|
MutS H728A
|

|
H728A
|

|
* Mildly defective ATPase activity
* Defective MutH activation ''in vitro''
* Moderately elevated mutation and DNA recombination rates ''in vivo''

|
PMID:12606120
|

|

|-
|
MutS S668A/T669A
|

|
S668A/T669A
|

|
*Modest reduction of Kcat (~three-fold)
*Fails to activate MMR
|
PMID:12606120
|

|

|-
|
MutS D693N
|

|
D693N
|

|
*Modest reduction of Kcat (~three-fold)
*Fails to activate MMR
|
PMID:12606120
|

|

|-
|
MutS S668A/T669A/E694A
|

|
S668A/T669A/E694A
|

|
*Defective in DNA binding
*Defective in MMR
*Catalyzes ATP hydrolysis better than single E694A mutant
|
PMID:12606120
|

|

|-
|
MutS K620M
|

|
K620M
|

|
*Severely reduced ATP binding capacity
*Fails to activate MutH in MMR initiation assays
|
PMID:12606120
|

|

|-
|
MutS E694Q
|

|
E694Q
|

|
*Binds ATP better than the wt MutS,but hydrolyzes ATP poorly
*Supports low-level MutH activation in a mismatch-independent manner
|
PMID:12606120
|

|

|-
|
MutS F36A
|

|
F36A
|

|
*Fails to recognize a mismatch site hence failing to initiate MMR
*Loses mismatch binding capacity
|
PMID:12606120
|

|

|-
|
MutS D693A
|

|
D693A
|

|
*Binds ATP better than the wt MutS,but hydrolyzes ATP poorly
*Supports low-level MutH activation in a mismatch-independent manner
|
PMID:12606120
|

|

|-
|
MutS E38Q
|

|
E38Q
|

|
*Binds DNA better than wt MutS
*Activates MutH ~50% more than the wt MutS in correlation with increased affinity for heteroduplex DNA
*Completely inactive in MMR and in preventing homologous recombination ''in vivo''
|
PMID:12606120
|

|

|-
|
MutS E694A
|

|
E694A
|

|
*Binds ATP better than the wt MutS,but hydrolyzes ATP poorly
*Supports low-level MutH activation in a mismatch-independent manner
|
PMID:12606120
|

|

|-
|
MutS E38A
|

|
E38A
|

|
*Exhibits moderately increased affinity for homoduplex DNA ''in vitro''
*MMR defective ''in vivo''
|
PMID:12606120
|

|

|-
|
MutS E177A
|

|
E177A
|

|
*Unable to form H bonds that link domains I and II
*Indistinguishable from Δ''mutS'' in the ''in vivo'' MMR and recombination assays
*Possesses a lower affinity for heteroduplex DNA ''in vitro'' in the presence of ATP
*Possesses a higher affinity for homoduplex DNA ''in vitro'' in the presence of ATP
*Hyperactive in activating MutH with 2-fold and 4-fold increases observed relative to the wt MutS for heteroduplex and homoduplex DNA, respectively
*Reduced ATP hydrolysis
|
PMID:12606120
|

|

|-
|
MutS T115A
|

|
T115A
|

|
*Unable to form H bonds that link domains I and II
*Indistinguishable from Δ''mutS'' in the ''in vivo'' MMR and recombination assays
*Possesses a lower affinity for heteroduplex DNA ''in vitro'' in the presence of ATP
*Possesses a higher affinity for homoduplex DNA ''in vitro'' in the presence of ATP
*Hyperactive in activating MutH with 2-fold and 4-fold increases observed relative to the wt MutS for heteroduplex and homoduplex DNA, respectively
*Reduced ATP hydrolysis
|
PMID:12606120
|

|

|-
|
MutS R197E/R198E
|

|
R197E/R198E
|

|
*Disrupts the domain interface more extensively than the E177A or T115A mutation
*''In vivo'' defects similar to E177A and T115A mutations
*Relatively normal DNA binding
*Slightly elevated affinity for homoduplex DNA in the presence of ATP
*Completely fails to activate MutH ''in vitro''
|
PMID:12606120
|

|

|-
|
MutS R197E/R198E/R199E
|

|
R197E/R198E/R199E
|

|
*Disrupts the domain interface more extensively than the E177A or T115A mutation
*''In vivo'' defects similar to E177A and T115A mutations
*Probably results in an unstable protein, which is found in inclusion bodies when over-expressed

|
PMID:12606120
|

|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Genetic Resources==
{{BacktoTop}}

{{Gene_resources_help}}
{| id="A46a9e4f3a3b08" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference
|-
|
JW2703
|
Plasmid clone
|
[http://www.shigen.nig.ac.jp/ecoli/strain/askaCloneQueryAction.do?strainTypeId=9 Shigen]
|
PMID:16769691

Status:Clone OK

Primer 1:GCCAGTGCAATAGAAAATTTCGA

Primer 2:CCaACCAGGCTCTTCAAGCGATA
|-
|
[[srlD:Gene|srlD3131::Tn10]]
|
Linked marker
|
CAG18642 = [http://cgsc2.biology.yale.edu/Strain.php?ID=40097 CGSC7423]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 32% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:zfh-3131::Tn10, zfi-3131::Tn10
|-
|
[[cysI:Gene|cysI95::Tn10]]
|
Linked marker
|
CAG12173 = [http://cgsc2.biology.yale.edu/Strain.php?ID=40099 CGSC7425]<ref name='LIB:cgsc'/>
|
est. P1 cotransduction: 30% <ref name='LIB:Nichols_linked_Tn'/> 
Synonyms:cysC95::Tn10

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.16031.A46a9e4f3a3b08&page=16031&pagename={{FULLPAGENAMEE}}&type=&template=Gene_resource_table edit table] || || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46a9e4f4471e6" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10625 EcoCyc:EG10625]
|

|-
|
[http://www.ecoli-york.org EchoBASE] ([[EchoBASE|EcoliWiki Page]])
|
[http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0620 EchoBASE:EB0620]
|

|-
|
[http://chase.ou.edu/oubcf/index.php EcoliGenExpDB] ([[EcoliGenExpDB|EcoliWiki Page]])
|
[http://chase.ou.edu/macro/searchlink.php?bnum=b2733 EcoliGenExpDB:b2733]
|

|-
|
[http://BioCyc.org/ECOL199310/ ECOL199310CYC] ([[ECOL199310CYC|EcoliWiki Page]])
|
[http://BioCyc.org/ECOL199310/new-image?object=C3294 ECOL199310CYC:C3294]
|

|-
|
[http://ecogene.org EcoGene] ([[EcoGene|EcoliWiki Page]])
|
[http://ecogene.org/geneinfo.php?eg_id=EG10625 EcoGene:EG10625]
|

|-
|
[http://BioCyc.org/ECOO157/ ECOO157CYC] ([[ECOO157CYC|EcoliWiki Page]])
|
[http://BioCyc.org/ECOO157/new-image?object=MUTS ECOO157CYC:MUTS]
|

|-
|
[http://cgsc.biology.yale.edu CGSC] ([[CGSC|EcoliWiki Page]])
|
[http://cgsc.biology.yale.edu/cgi-bin/sybgw/cgsc/Site/469 CGSC:469]
|

|-
|
[https://asap.ahabs.wisc.edu/asap/logon.php ASAP] ([[ASAP|EcoliWikiPage]])
|
[http://asap.ahabs.wisc.edu/asap/feature_info.php?LocationID=WIS&FeatureID=0008977&formSubmitReturn=1 ASAP:ABE-0008977]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.16031.V46a9e4f4471e6&page=16031&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="D46a7016144f94" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.16031.D46a7016144f94&page=16031&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude><protect>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
[[Category:Gene List:MG1655]]
[[Category:Gene List:W3110]]
[[Category:Gene_List:DH10B]]
[[Category:Gene_List:REL606]]
[[Category:Gene_List:BW2952]]
[[Category:Genes in the Keio knockout collection]]
[[Category:Genes in the ASKA clone collection]]
[[Category:mut genes]]

PMID:21113127

2011-04-06T16:08:13Z

Azweifel: Fill PMID: Page!

{{RightTOC}}
<protect>
 '''Tonthat, NK, Arold, ST, Pickering, BF, Van Dyke, MW, Liang, S, Lu, Y, Beuria, TK, Margolin, W and Schumacher, MA''' (2011) Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.''EMBO J.'' '''30''':154-64

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>In Escherichia coli, cytokinesis is orchestrated by FtsZ, which forms a Z-ring to drive septation. Spatial and temporal control of Z-ring formation is achieved by the Min and nucleoid occlusion (NO) systems. Unlike the well-studied Min system, less is known about the anti-DNA guillotining NO process. Here, we describe studies addressing the molecular mechanism of SlmA (synthetic lethal with a defective Min system)-mediated NO. SlmA contains a TetR-like DNA-binding fold, and chromatin immunoprecipitation analyses show that SlmA-binding sites are dispersed on the chromosome except the Ter region, which segregates immediately before septation. SlmA binds DNA and FtsZ simultaneously, and the SlmA-FtsZ structure reveals that two FtsZ molecules sandwich a SlmA dimer. In this complex, FtsZ can still bind GTP and form protofilaments, but the separated protofilaments are forced into an anti-parallel arrangement. This suggests that SlmA may alter FtsZ polymer assembly. Indeed, electron microscopy data, showing that SlmA-DNA disrupts the formation of normal FtsZ polymers and induces distinct spiral structures, supports this. Thus, the combined data reveal how SlmA derails Z-ring formation at the correct place and time to effect NO.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21113127 PubMed]
Online version:[http://dx.doi.org/10.1038/emboj.2010.288 10.1038/emboj.2010.288]
|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{| id="H4d9c8fedb51c8" class=" tableEdit GO_table_reference"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177560.H4d9c8fedb51c8&page=177560&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==See also==

==References==
{{RefHelp}}
<references/>

PMID:21113127

2011-04-06T16:08:13Z

Azweifel: New PMID: Page!

slmA:Gene Product(s)

2011-04-06T16:07:57Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete
|-
|

|
GO:0032272
|
negative regulation of protein polymerization
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figures 1, 3 and S3- interferes with FtsZ polymerization
|
complete
|-
|

|
GO:0000918
|
barrier septum formation
|
PMID:15916962
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Figure 3
|
complete
|-
|

|
GO:0010974
|
cell division
|
PMID:15916962
|
IGI: Inferred from Genetic Interaction
|
EcoliWiki:minB

|
P
|
Figure 1 and 2
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
consensus binding dramatically enhances SlmA's ability to interfere with FtsZ polymerization
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
||
SlmA-FtsZ structure
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
||
PMID:21113127

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] || ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-06T16:04:59Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete
|-
|

|
GO:0032272
|
negative regulation of protein polymerization
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figures 1, 3 and S3- interferes with FtsZ polymerization
|
complete
|-
|

|
GO:0000918
|
barrier septum formation
|
PMID:15916962
|
IMP: Inferred from Mutant Phenotype
|

|
P
|
Figure 3
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
consensus binding dramatically enhances SlmA's ability to interfere with FtsZ polymerization
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
||
SlmA-FtsZ structure
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
||
PMID:21113127

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] || ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T21:05:25Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete
|-
|

|
GO:0032272
|
negative regulation of protein polymerization
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figures 1, 3 and S3- interferes with FtsZ polymerization
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
consensus binding dramatically enhances SlmA's ability to interfere with FtsZ polymerization
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
||
SlmA-FtsZ structure
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
||
PMID:21113127

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] || ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T20:53:03Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete
|-
|

|
GO:0032272
|
negative regulation of protein polymerization
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figures 1, 3 and S3- interferes with FtsZ polymerization
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
consensus binding dramatically enhances SlmA's ability to interfere with FtsZ polymerization
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T20:52:09Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete
|-
|

|
GO:0032272
|
negative regulation of protein polymerization
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figures 1, 3 and S3
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
consensus binding dramatically enhances SlmA's ability to interfere with FtsZ polymerization
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

ftsZ:Gene Product(s)

2011-04-05T20:50:12Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsZ}}{{Tab|Gene|ftsZ}}{{Tab On|Gene Product(s)|ftsZ}}{{Tab|Expression|ftsZ}}{{Tab|Evolution|ftsZ}}{{Tab|On One Page|ftsZ}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="H46aa1b6e0ee25" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsZ
|-
!align=left {{table heading style}} |Synonyms
||
GTP-binding tubulin-like cell division protein<ref name='LIB:Riley_2006'/>, B0095<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SulB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfiB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Septal ring GTPase required for cell division and growth; initiation of septation<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="V46aa1b6f0a8a5" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0003924
|
GTPase activity
|
PMID:1528267
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
PMID:1943703
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
PMID:8917533
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0717
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032155
|
cell division site part
|
PMID:9603865
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:2045370
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0005525
|
GTP binding
|
PMID:1528267
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000158
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
PMID:1528268
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
PMID:1528268
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsE
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020805
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8917533
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsA
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:zipA
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0342
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:sulA

|
F
|

|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000158
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020805
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0086
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003008
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003008
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|

|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: reference
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:zapA

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsZ

|
F
|

|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3
|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aa1b754be13" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
add 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
dnaK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
ftsK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
fusA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
gatY 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
malK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
mreB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
pstB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
recA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rplE 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsE 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsJ 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
secA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
tufA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
pflB 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
rpsD 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
uspG 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
yedD 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
moaC 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
tatE 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
rplN 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
SulA
|
FtsZ full length and truncations
|
PMID:8752322
|
2 hybrid
|-
|
Protein
|
FtsA
|
FtsA/FtsZ ratio is important for cell division

|
PMID:1400163

PMID:1400183

|
Genetic Interference
|-
|
Protein
|
FtsA
|
FtsA may link Z-ring to septal specific peptidoglycan biosynthesis
|
PMID:6365891
|

|-
|
Protein
|
SlmA
|

|
PMID:21321206
|
Bacterial 2 hybrid

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|}


</protect>
===Notes===
*FtsZ is a key player in [[Septation]]
*FtsZ contains a fairly strong activation domain (AD) and cannot be used as the bait in 2 hybrid screens.<ref name='PMID:8752322'/>

==Localization==

{{Product_localization_help}}
{| id="Y46aa1b75ef068" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|-
|
cytoplasm
|

|
fractionation experiments
|
PMID:1943703
|

|-
|
cytoplasm
|

|
fractionation
|
PMID:1528267
|
membrane-associated in the presence of GTP

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.Y46aa1b75ef068&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="S46aa1b775e78b" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10347-MONOMER at EcoCyc]
<pre>MFEPMELTND AVIKVIGVGG GGGNAVEHMV RERIEGVEFF AVNTDAQALR KTAVGQTIQI
GSGITKGLGA GANPEVGRNA ADEDRDALRA ALEGADMVFI AAGMGGGTGT GAAPVVAEVA
KDLGILTVAV VTKPFNFEGK KRMAFAEQGI TELSKHVDSL ITIPNDKLLK VLGRGISLLD
AFGAANDVLK GAVQGIAELI TRPGLMNVDF ADVRTVMSEM GYAMMGSGVA SGEDRAEEAA
EMAISSPLLE DIDLSGARGV LVNITAGFDL RLDEFETVGN TIRAFASDNA TVVIGTSLDP
DMNDELRVTV VATGIGMDKR PEITLVTNKQ VQQPVMDRYQ QHGMAPLTQE QKPVAKVVND
NAPQTAKEPD YLDIPAFLRK QAD</pre>
|-
!align=left {{table heading style}} |Length
||
383
|-
!align=left {{table heading style}} |Mol. Wt
||
40.323 kDa
|-
!align=left {{table heading style}} |pI
||
4.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
4,470 (calc based on 3 Y, W, and C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.S46aa1b775e78b&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="G46aa1b77b6764" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
12..184
|
[http://pfam.janelia.org/family/PF00091 PF00091 Tubulin/FtsZ family, GTPase domain]
|

|
PMID:19920124
|-
|
Domain
|
221..318
|
[http://pfam.janelia.org/family/PF12327 PF12327 FtsZ family, C-terminal domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.G46aa1b77b6764&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="V46a731173cd13" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsZ
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.V46a731173cd13&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
*The dynamics of FtsZ ring formation/constriction was investigated in Addinall ''et al.''(1997)<ref name='PMID:9209044'/>.
*Aluminum fluoride abolishes FtsZ GTPase activity<ref name='PMID:8083192'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="C46aa1b78550f6" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
FtsZ D212N- defective GTPase activity
|
PMID: 21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.C46aa1b78550f6&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46aa1b789e0a2" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10347-MONOMER EcoCyc:EG10347-MONOMER]
|

|-
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0A9A6 SwissModel:P0A9A6]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0A9A6 UniProt:P0A9A6]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0A9A6 Pfam:P0A9A6]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414637 RefSeq:NP_414637]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.G46aa1b789e0a2&page=19676&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Z46a7311aef91b" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.Z46a7311aef91b&page=19676&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

Cis Element:SBS

2011-04-05T20:37:37Z

Azweifel: Table edited by Azweifel via TableEdit

__NOTOC__
==Cis element summary table==
<protect>

{| id="S4d9b7ca1856b0" class=" tableEdit Cis_element_summary_table"

|-
!align=left {{table_heading_style}} |Standard Name
||
SBS
|-
!align=left {{table_heading_style}} |Synonyms
||
SlmA binding sequences
|-
!align=left {{table_heading_style}} |Function
||

|-
!align=left {{table_heading_style}} |Location
||

|-
!align=left {{table_heading_style}} |SO terms
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.S4d9b7ca1856b0&page=177555&pagename={{FULLPAGENAMEE}}&type=1&template=Cis_element_summary_table edit table] ||
|}
</protect>
===Notes===

== Location and Sequence ==
{{BacktoTop}}
<protect>
{{Gene_location_help}}
{| id="A4d9b7ca18f7f5" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.A4d9b7ca18f7f5&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}
</protect>

===Notes===

== Interactions==
{{BacktoTop}}
<protect>
{{Product_interactions_help}}
{| id="U4d9b7ca192e3d" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
SlmA
|

|
PMID:21321206
|
Figure 2 and S7- EMSA
|-
|
Protein
|
SlmA
|

|
PMID:21113127
|
ChIP

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.U4d9b7ca192e3d&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Product_interactions_table edit table] || || || ||
|}
</protect>

===Notes===

== Mutant alleles and phenotypes ==
{{BacktoTop}}
<protect>

{| id="X4d9b7ca1972c4" class=" tableEdit Cis_Element_allele_table"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.X4d9b7ca1972c4&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Cis_Element_allele_table edit table] || || || || || ||
|}
</protect>

===Notes===

== Genetic Resources ==
{{BacktoTop}}
<protect>
{{Gene_resources_help}}
{| id="O4d9b7ca1993d6" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.O4d9b7ca1993d6&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_resource_table edit table] || || ||
|}
</protect>
===Notes===

== Accessions ==
{{BacktoTop}}
<protect>
{{Gene_accessions_help}}
{| id="F4d9b7ca19b587" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.F4d9b7ca19b587&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}
</protect>

===Notes===

==References==
{{BacktoTop}}
{{RefHelp}}
<references/>

===Categories===[[Category:Cis_Element]]

Cis Element:SBS

2011-04-05T20:35:26Z

Azweifel: Table edited by Azweifel via TableEdit

__NOTOC__
==Cis element summary table==
<protect>

{| id="S4d9b7ca1856b0" class=" tableEdit Cis_element_summary_table"

|-
!align=left {{table_heading_style}} |Standard Name
||
SBS
|-
!align=left {{table_heading_style}} |Synonyms
||
SlmA binding sequences
|-
!align=left {{table_heading_style}} |Function
||

|-
!align=left {{table_heading_style}} |Location
||

|-
!align=left {{table_heading_style}} |SO terms
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.S4d9b7ca1856b0&page=177555&pagename={{FULLPAGENAMEE}}&type=1&template=Cis_element_summary_table edit table] ||
|}
</protect>
===Notes===

== Location and Sequence ==
{{BacktoTop}}
<protect>
{{Gene_location_help}}
{| id="A4d9b7ca18f7f5" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.A4d9b7ca18f7f5&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}
</protect>

===Notes===

== Interactions==
{{BacktoTop}}
<protect>
{{Product_interactions_help}}
{| id="U4d9b7ca192e3d" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
SlmA
|

|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.U4d9b7ca192e3d&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Product_interactions_table edit table] || || || ||
|}
</protect>

===Notes===

== Mutant alleles and phenotypes ==
{{BacktoTop}}
<protect>

{| id="X4d9b7ca1972c4" class=" tableEdit Cis_Element_allele_table"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.X4d9b7ca1972c4&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Cis_Element_allele_table edit table] || || || || || ||
|}
</protect>

===Notes===

== Genetic Resources ==
{{BacktoTop}}
<protect>
{{Gene_resources_help}}
{| id="O4d9b7ca1993d6" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.O4d9b7ca1993d6&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_resource_table edit table] || || ||
|}
</protect>
===Notes===

== Accessions ==
{{BacktoTop}}
<protect>
{{Gene_accessions_help}}
{| id="F4d9b7ca19b587" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.F4d9b7ca19b587&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}
</protect>

===Notes===

==References==
{{BacktoTop}}
{{RefHelp}}
<references/>

===Categories===[[Category:Cis_Element]]

Cis Element:SBS

2011-04-05T20:34:27Z

Azweifel: Table edited by Azweifel via TableEdit

__NOTOC__
==Cis element summary table==
<protect>

{| id="S4d9b7ca1856b0" class=" tableEdit Cis_element_summary_table"

|-
!align=left {{table_heading_style}} |Standard Name
||
SBS
|-
!align=left {{table_heading_style}} |Synonyms
||
SlmA binding sequences
|-
!align=left {{table_heading_style}} |Function
||

|-
!align=left {{table_heading_style}} |Location
||

|-
!align=left {{table_heading_style}} |SO terms
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.S4d9b7ca1856b0&page=177555&pagename={{FULLPAGENAMEE}}&type=1&template=Cis_element_summary_table edit table] ||
|}
</protect>
===Notes===

== Location and Sequence ==
{{BacktoTop}}
<protect>
{{Gene_location_help}}
{| id="A4d9b7ca18f7f5" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.A4d9b7ca18f7f5&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}
</protect>

===Notes===

== Interactions==
{{BacktoTop}}
<protect>
{{Product_interactions_help}}
{| id="U4d9b7ca192e3d" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.U4d9b7ca192e3d&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Product_interactions_table edit table] || || || ||
|}
</protect>

===Notes===

== Mutant alleles and phenotypes ==
{{BacktoTop}}
<protect>

{| id="X4d9b7ca1972c4" class=" tableEdit Cis_Element_allele_table"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.X4d9b7ca1972c4&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Cis_Element_allele_table edit table] || || || || || ||
|}
</protect>

===Notes===

== Genetic Resources ==
{{BacktoTop}}
<protect>
{{Gene_resources_help}}
{| id="O4d9b7ca1993d6" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.O4d9b7ca1993d6&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_resource_table edit table] || || ||
|}
</protect>
===Notes===

== Accessions ==
{{BacktoTop}}
<protect>
{{Gene_accessions_help}}
{| id="F4d9b7ca19b587" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.F4d9b7ca19b587&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}
</protect>

===Notes===

==References==
{{BacktoTop}}
{{RefHelp}}
<references/>

===Categories===[[Category:Cis_Element]]

Talk:Cis Element:SBS

2011-04-05T20:33:38Z

Azweifel:

Cis Element:SBS

2011-04-05T20:33:37Z

Azweifel: add pages for this cis-element

__NOTOC__
==Cis element summary table==
<protect>

{| id="S4d9b7ca1856b0" class=" tableEdit Cis_element_summary_table"

|-
!align=left {{table_heading_style}} |Standard Name
|-
!align=left {{table_heading_style}} |Synonyms
|-
!align=left {{table_heading_style}} |Function
|-
!align=left {{table_heading_style}} |Location
|-
!align=left {{table_heading_style}} |SO terms

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.S4d9b7ca1856b0&page=177555&pagename={{FULLPAGENAMEE}}&type=1&template=Cis_element_summary_table edit table]
|}
</protect>
===Notes===

== Location and Sequence ==
{{BacktoTop}}
<protect>
{{Gene_location_help}}
{| id="A4d9b7ca18f7f5" class=" tableEdit Gene_location_table"
|- {{table_heading_style}}
!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.A4d9b7ca18f7f5&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_location_table edit table] || || || ||
|}
</protect>

===Notes===

== Interactions==
{{BacktoTop}}
<protect>
{{Product_interactions_help}}
{| id="U4d9b7ca192e3d" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.U4d9b7ca192e3d&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Product_interactions_table edit table] || || || ||
|}
</protect>

===Notes===

== Mutant alleles and phenotypes ==
{{BacktoTop}}
<protect>

{| id="X4d9b7ca1972c4" class=" tableEdit Cis_Element_allele_table"
|- {{table_heading_style}}
!|Allele!!Nt change(s)!!Phenotype: Type!!Phenotype: Description!!Reference!!Availability!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.X4d9b7ca1972c4&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Cis_Element_allele_table edit table] || || || || || ||
|}
</protect>

===Notes===

== Genetic Resources ==
{{BacktoTop}}
<protect>
{{Gene_resources_help}}
{| id="O4d9b7ca1993d6" class=" tableEdit Gene_resource_table"
|- {{table_heading_style}}
!|Resource!!Resource Type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.O4d9b7ca1993d6&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_resource_table edit table] || || ||
|}
</protect>
===Notes===

== Accessions ==
{{BacktoTop}}
<protect>
{{Gene_accessions_help}}
{| id="F4d9b7ca19b587" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177555.F4d9b7ca19b587&page=177555&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}
</protect>

===Notes===

==References==
{{BacktoTop}}
{{RefHelp}}
<references/>

===Categories===[[Category:Cis_Element]]

Cis Element:SBS

2011-04-05T20:33:37Z

Azweifel: ok

__NOTOC__
==Cis element summary table==
<newTableEdit>Template:Cis_element_summary_table</newTableEdit>
===Notes===

== Location and Sequence ==
{{BacktoTop}}
<newTableEdit>Template:Gene_location_table</newTableEdit>

===Notes===

== Interactions==
{{BacktoTop}}
<newTableEdit>Template:Product_interactions_table</newTableEdit>

===Notes===

== Mutant alleles and phenotypes ==
{{BacktoTop}}
<newTableEdit>Template:Cis_Element_allele_table</newTableEdit>

===Notes===

== Genetic Resources ==
{{BacktoTop}}
<newTableEdit>Template:Gene resource table </newTableEdit>
===Notes===

== Accessions ==
{{BacktoTop}}
<newTableEdit>Template:Gene accessions table</newTableEdit>

===Notes===

==References==
{{BacktoTop}}
{{RefHelp}}
<references/>

===Categories===

slmA:Gene Product(s)

2011-04-05T20:31:04Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
consensus binding dramatically enhances SlmA's ability to interfere with FtsZ polymerization
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T20:27:09Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|

|
PMID:15916962
|

|-
|
DNA
|
SlmA binding sequence
|
SBS17- GTTAGTGACCATTTACTTAC
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T20:25:49Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0010974
|
negative regulation of barrier septum formation
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 3 and S3- SlmA destabilizes FtsZ polymers
|
complete
|-
|

|
GO:0043547
|
positive regulation of GTPase activity
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
P
|
Figure 4A- SlmA bound to consensus DNA increases FtsZ's GTPase activity
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:21321206
|
IDA: Inferred from Direct Assay
|

|
F
|
Figure S7- EMSA
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|
PMID:15916962
|

|

|-
|
DNA
|
SlmA binding sequence
|
SBS17- GTTAGTGACCATTTACTTAC
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T20:09:55Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid
|-
|
Protein
|
FtsZ
|
PMID:15916962
|

|

|-
|
DNA
|
SlmA binding sequence
|
SBS17- GTTAGTGACCATTTACTTAC
|
PMID:21321206
|
Figure 2 and S7- EMSA

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

slmA:Gene Product(s)

2011-04-05T20:07:26Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.B46aaf88ca97ae&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.X46aaf88dd45cc&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|
PMID:15916962
|

|

|-
|
Protein
|
FtsZ
|

|
PMID:21321206
|
Bacterial 2 hybrid

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.J46aaf89113575&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.W46a8855ea7c2f&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Q46aaf89314651&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46aaf894cad7f&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

ftsZ:Gene Product(s)

2011-04-05T20:04:03Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsZ}}{{Tab|Gene|ftsZ}}{{Tab On|Gene Product(s)|ftsZ}}{{Tab|Expression|ftsZ}}{{Tab|Evolution|ftsZ}}{{Tab|On One Page|ftsZ}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="H46aa1b6e0ee25" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsZ
|-
!align=left {{table heading style}} |Synonyms
||
GTP-binding tubulin-like cell division protein<ref name='LIB:Riley_2006'/>, B0095<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SulB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfiB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Septal ring GTPase required for cell division and growth; initiation of septation<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.H46aa1b6e0ee25&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="V46aa1b6f0a8a5" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0003924
|
GTPase activity
|
PMID:1528267
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
PMID:1943703
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
PMID:8917533
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0717
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032155
|
cell division site part
|
PMID:9603865
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:2045370
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0005525
|
GTP binding
|
PMID:1528267
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000158
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
PMID:1528268
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
PMID:1528268
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsE
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020805
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8917533
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsA
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:zipA
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0342
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:sulA

|
F
|

|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000158
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020805
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0086
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003008
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003008
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|

|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: reference
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:zapA

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsZ

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.V46aa1b6f0a8a5&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aa1b754be13" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
add 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
dnaK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
ftsK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
fusA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
gatY 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
malK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
mreB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
pstB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
recA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rplE 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsE 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsJ 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
secA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
tufA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
pflB 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
rpsD 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
uspG 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
yedD 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
moaC 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
tatE 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
rplN 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
SulA
|
FtsZ full length and truncations
|
PMID:8752322
|
2 hybrid
|-
|
Protein
|
FtsA
|
FtsA/FtsZ ratio is important for cell division

|
PMID:1400163

PMID:1400183

|
Genetic Interference
|-
|
Protein
|
FtsA
|
FtsA may link Z-ring to septal specific peptidoglycan biosynthesis
|
PMID:6365891
|

|-
|
Protein
|
SlmA
|

|
PMID:21321206
|
Bacterial 2 hybrid

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.J46aa1b754be13&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===
*FtsZ is a key player in [[Septation]]
*FtsZ contains a fairly strong activation domain (AD) and cannot be used as the bait in 2 hybrid screens.<ref name='PMID:8752322'/>

==Localization==

{{Product_localization_help}}
{| id="Y46aa1b75ef068" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|-
|
cytoplasm
|

|
fractionation experiments
|
PMID:1943703
|

|-
|
cytoplasm
|

|
fractionation
|
PMID:1528267
|
membrane-associated in the presence of GTP

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.Y46aa1b75ef068&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="S46aa1b775e78b" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10347-MONOMER at EcoCyc]
<pre>MFEPMELTND AVIKVIGVGG GGGNAVEHMV RERIEGVEFF AVNTDAQALR KTAVGQTIQI
GSGITKGLGA GANPEVGRNA ADEDRDALRA ALEGADMVFI AAGMGGGTGT GAAPVVAEVA
KDLGILTVAV VTKPFNFEGK KRMAFAEQGI TELSKHVDSL ITIPNDKLLK VLGRGISLLD
AFGAANDVLK GAVQGIAELI TRPGLMNVDF ADVRTVMSEM GYAMMGSGVA SGEDRAEEAA
EMAISSPLLE DIDLSGARGV LVNITAGFDL RLDEFETVGN TIRAFASDNA TVVIGTSLDP
DMNDELRVTV VATGIGMDKR PEITLVTNKQ VQQPVMDRYQ QHGMAPLTQE QKPVAKVVND
NAPQTAKEPD YLDIPAFLRK QAD</pre>
|-
!align=left {{table heading style}} |Length
||
383
|-
!align=left {{table heading style}} |Mol. Wt
||
40.323 kDa
|-
!align=left {{table heading style}} |pI
||
4.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
4,470 (calc based on 3 Y, W, and C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.S46aa1b775e78b&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="G46aa1b77b6764" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
12..184
|
[http://pfam.janelia.org/family/PF00091 PF00091 Tubulin/FtsZ family, GTPase domain]
|

|
PMID:19920124
|-
|
Domain
|
221..318
|
[http://pfam.janelia.org/family/PF12327 PF12327 FtsZ family, C-terminal domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.G46aa1b77b6764&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="V46a731173cd13" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsZ
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.V46a731173cd13&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
*The dynamics of FtsZ ring formation/constriction was investigated in Addinall ''et al.''(1997)<ref name='PMID:9209044'/>.
*Aluminum fluoride abolishes FtsZ GTPase activity<ref name='PMID:8083192'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="C46aa1b78550f6" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
FtsZ D212N- defective GTPase activity
|
PMID: 21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.C46aa1b78550f6&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46aa1b789e0a2" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10347-MONOMER EcoCyc:EG10347-MONOMER]
|

|-
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0A9A6 SwissModel:P0A9A6]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0A9A6 UniProt:P0A9A6]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0A9A6 Pfam:P0A9A6]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414637 RefSeq:NP_414637]
|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Z46a7311aef91b" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.Z46a7311aef91b&page=19676&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

ftsZ:Gene Product(s)

2011-04-05T20:02:45Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|ftsZ}}{{Tab|Gene|ftsZ}}{{Tab On|Gene Product(s)|ftsZ}}{{Tab|Expression|ftsZ}}{{Tab|Evolution|ftsZ}}{{Tab|On One Page|ftsZ}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="H46aa1b6e0ee25" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
FtsZ
|-
!align=left {{table heading style}} |Synonyms
||
GTP-binding tubulin-like cell division protein<ref name='LIB:Riley_2006'/>, B0095<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SulB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SfiB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FtsZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
essential cell division protein FtsZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Septal ring GTPase required for cell division and growth; initiation of septation<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.H46aa1b6e0ee25&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| {{Prettytable}} id="V46aa1b6f0a8a5" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0003924
|
GTPase activity
|
PMID:1528267
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
PMID:1943703
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
PMID:8917533
|
IDA: Inferred from Direct Assay
|

|
P
|

|
complete
|-
|

|
GO:0000166
|
nucleotide binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0547
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0717
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0032155
|
cell division site part
|
PMID:9603865
|
IDA: Inferred from Direct Assay
|

|
C
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
PMID:2045370
|
IMP: Inferred from Mutant Phenotype
|

|
P
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: with/from
|-
|

|
GO:0005525
|
GTP binding
|
PMID:1528267
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000158
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003924
|
GTPase activity
|
PMID:1528268
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
PMID:1528268
|
IDA: Inferred from Direct Assay
|

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:17307852
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsE
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020805
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8917533
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:ftsA
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:9008158
|
IDA: Inferred from Direct Assay
|

|
F
|
EcoliWiki:zipA
|
complete
|-
|

|
GO:0005525
|
GTP binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0342
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:8752322
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:sulA

|
F
|

|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000158
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020805
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0086
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003008
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0043234
|
protein complex
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR003008
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR008280
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051258
|
protein polymerization
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018316
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|

|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132

|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
Missing: reference
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:zapA

|
F
|

|
complete
|-
|

|
GO:0005515
|
protein binding
|
PMID:20497333
|
IPI: Inferred from Physical Interaction
|
EcoliWiki:ftsZ

|
F
|

|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.V46aa1b6f0a8a5&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aa1b754be13" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
add 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
dnaK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
ftsK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
fusA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
gatY 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
malK 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
mreB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
pstB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
recA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rplE 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsB 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsE 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
rpsJ 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
secA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
tufA 
|

|
PMID:15690043
|
Experiment(s):EBI-889279 
|-
|
Protein
|
pflB 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
rpsD 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
uspG 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
yedD 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
moaC 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
tatE 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
rplN 
|

|
PMID:16606699
|
Experiment(s):EBI-1135563 
|-
|
Protein
|
SulA
|
FtsZ full length and truncations
|
PMID:8752322
|
2 hybrid
|-
|
Protein
|
FtsA
|
FtsA/FtsZ ratio is important for cell division

|
PMID:1400163

PMID:1400183

|
Genetic Interference
|-
|
Protein
|
FtsA
|
FtsA may link Z-ring to septal specific peptidoglycan biosynthesis
|
PMID:6365891
|

|-
|
Protein
|
SlmA
|

|
PMID:21321206
|
Bacterial 2 hybrid

|- class="tableEdit_footer"
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|}


</protect>
===Notes===
*FtsZ is a key player in [[Septation]]
*FtsZ contains a fairly strong activation domain (AD) and cannot be used as the bait in 2 hybrid screens.<ref name='PMID:8752322'/>

==Localization==

{{Product_localization_help}}
{| id="Y46aa1b75ef068" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
cytoplasm
|

|

|
From EcoCyc<ref name='LIB:EcoCyc11.1'/>
|

|-
|
cytoplasm
|

|
fractionation experiments
|
PMID:1943703
|

|-
|
cytoplasm
|

|
fractionation
|
PMID:1528267
|
membrane-associated in the presence of GTP

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.Y46aa1b75ef068&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="S46aa1b775e78b" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG10347-MONOMER at EcoCyc]
<pre>MFEPMELTND AVIKVIGVGG GGGNAVEHMV RERIEGVEFF AVNTDAQALR KTAVGQTIQI
GSGITKGLGA GANPEVGRNA ADEDRDALRA ALEGADMVFI AAGMGGGTGT GAAPVVAEVA
KDLGILTVAV VTKPFNFEGK KRMAFAEQGI TELSKHVDSL ITIPNDKLLK VLGRGISLLD
AFGAANDVLK GAVQGIAELI TRPGLMNVDF ADVRTVMSEM GYAMMGSGVA SGEDRAEEAA
EMAISSPLLE DIDLSGARGV LVNITAGFDL RLDEFETVGN TIRAFASDNA TVVIGTSLDP
DMNDELRVTV VATGIGMDKR PEITLVTNKQ VQQPVMDRYQ QHGMAPLTQE QKPVAKVVND
NAPQTAKEPD YLDIPAFLRK QAD</pre>
|-
!align=left {{table heading style}} |Length
||
383
|-
!align=left {{table heading style}} |Mol. Wt
||
40.323 kDa
|-
!align=left {{table heading style}} |pI
||
4.5 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
4,470 (calc based on 3 Y, W, and C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.S46aa1b775e78b&page=19676&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="G46aa1b77b6764" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
12..184
|
[http://pfam.janelia.org/family/PF00091 PF00091 Tubulin/FtsZ family, GTPase domain]
|

|
PMID:19920124
|-
|
Domain
|
221..318
|
[http://pfam.janelia.org/family/PF12327 PF12327 FtsZ family, C-terminal domain]
|

|
PMID:19920124

|- class="tableEdit_footer"
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|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="V46a731173cd13" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=ftsZ
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
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|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===
*The dynamics of FtsZ ring formation/constriction was investigated in Addinall ''et al.''(1997)<ref name='PMID:9209044'/>.
*Aluminum fluoride abolishes FtsZ GTPase activity<ref name='PMID:8083192'/>.

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="C46aa1b78550f6" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.C46aa1b78550f6&page=19676&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="G46aa1b789e0a2" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10347-MONOMER EcoCyc:EG10347-MONOMER]
|

|-
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P0A9A6 SwissModel:P0A9A6]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0A9A6 UniProt:P0A9A6]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0A9A6 Pfam:P0A9A6]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414637 RefSeq:NP_414637]
|

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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="Z46a7311aef91b" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.19676.Z46a7311aef91b&page=19676&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

slmA:Gene Product(s)

2011-04-05T20:01:09Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|slmA}}{{Tab|Gene|slmA}}{{Tab On|Gene Product(s)|slmA}}{{Tab|Expression|slmA}}{{Tab|Evolution|slmA}}{{Tab|On One Page|slmA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="B46aaf88ca97ae" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
SlmA
|-
!align=left {{table heading style}} |Synonyms
||
division inhibitor<ref name='LIB:Riley_2006'/>, B3641<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YicB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ttk<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SlmA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
cell division inhibitor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Division inhibitor that binds FtsZ and blocks septal rings; DNA-associated<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

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|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="X46aaf88dd45cc" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0000917
|
barrier septum formation
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003700
|
transcription factor activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:hamap GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_01839
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005737
|
cytoplasm
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006350
|
transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0804
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006355
|
regulation of transcription, DNA-dependent
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR001647
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0007049
|
cell cycle
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0131
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0009295
|
nucleoid
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-0187
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030528
|
transcription regulator activity
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011075
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012287
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0003677
|
DNA binding
|
PMID:15916962
|
IDA: Inferred from Direct Assay
|

|
F
|
fluorescence microscopy- colocalization with DNA
|
complete
|-
|

|
GO:0045449
|
regulation of transcription
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0805
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0051301
|
cell division
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0132
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete

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|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="J46aaf89113575" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-
|
Protein
|
FtsZ
|
PMID:15916962
|

|

|- class="tableEdit_footer"
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|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="W46a8855ea7c2f" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
Nucleoid
|

|
Fluorescence microscopy
|
PMID:15916962
|

|- class="tableEdit_footer"
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|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="Q46aaf89314651" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=EG11191-MONOMER at EcoCyc]
<pre>MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYTTDET LLASQILAFC
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ</pre>
|-
!align=left {{table heading style}} |Length
||
212
|-
!align=left {{table heading style}} |Mol. Wt
||
24.319 kDa
|-
!align=left {{table heading style}} |pI
||
8.8 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
9,970 - 10,345 (calc based on 3 Y, 1 W, and 3 C residues)

|- class="tableEdit_footer"
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|}


<big>'''Domains/Motifs/Modification Sites'''</big><table>
<tr align="left" valign="top">
<td>
{{Product_domains_motifs_help}}
{| id="K46aaf89389fa9" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
Domain
|
16..62
|
[http://pfam.janelia.org/family/PF00440 PF00440 Bacterial regulatory proteins, tetR family]
|

|
PMID:19920124

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.K46aaf89389fa9&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}
</td>
<td>


<motif_map/>
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="L46a8856048d4f" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=slmA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.L46a8856048d4f&page=27848&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="Y46aaf89465bb3" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference
|-
|
Purified protein
|
SlmA R73D- aberrant FtsZ binding
|
PMID:21321206
|-
|
Purified protein
|
SlmA T33A- aberrant DNA binding
|
PMID:21321206

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.Y46aaf89465bb3&page=27848&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="V46aaf894cad7f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11191-MONOMER EcoCyc:EG11191-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P0C093 UniProt:P0C093]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P0C093 Pfam:P0C093]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418098 RefSeq:NP_418098]
|

|- class="tableEdit_footer"
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|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="V46a88563c78ed" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27848.V46a88563c78ed&page=27848&pagename={{FULLPAGENAMEE}}&type=0&template=Links_table edit table] || ||
|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}

kefA:Gene Product(s)

2011-03-28T20:56:45Z

Azweifel: Table edited by Azweifel via TableEdit

{{#css:Suppresslinks.css}}<css>{{:Suppresslinks.css}}</css>
<noinclude>{{TabsTop}}
{{Tab|Quickview|kefA}}{{Tab|Gene|kefA}}{{Tab On|Gene Product(s)|kefA}}{{Tab|Expression|kefA}}{{Tab|Evolution|kefA}}{{Tab|On One Page|kefA}}{{TabsBottom}}
{|
|-
|{{Sub}}[[#Nomenclature |Nomenclature]]
|{{Sub}}[[#Function |Function]]
|{{Sub}}[[#Interactions |Interactions]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Accessions in Other Databases |Accessions]]
|{{Sub}}[[#Links |Links]]
|{{Sub}}[[#References| References]]
|{{Sub}}[[Talk:{{PAGENAMEE}}| Suggestions]]
|}
</noinclude>
==Nomenclature==

{{Product_nomenclature_help}}
{| id="V46aa318ca7d49" class=" tableEdit Product_nomenclature_table"

|-
!align=left {{table heading style}} |Standard name
||
KefA
|-
!align=left {{table heading style}} |Synonyms
||
fused conserved protein<ref name='LIB:Riley_2006'/>, mechanosensitive channel protein<ref name='LIB:Riley_2006'/>, B0465<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MscK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, KefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
|-
!align=left {{table heading style}} |Product description
||
KefA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>

Mechanosensitive channel protein, intermediate conductance; regulation of ion balance and turgor pressure at high osmolarity; also may affect activity of mechanosensitive channel MscS<ref name='LIB:EcoGene'/>
|-
!align=left {{table heading style}} |EC number (for enzymes)
||

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.V46aa318ca7d49&page=20589&pagename={{FULLPAGENAMEE}}&type=1&template=Product_nomenclature_table edit table] ||
|}


<protect></protect>
===Notes===

==Function==
{{BacktoTop}}
<protect>
<big>'''Gene Ontology'''</big> 
{{Product_GO_help}}
{| id="H46aa318da897d" class=" tableEdit GO_table_product dataTable"
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0997
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0005886
|
plasma membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-1003
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006810
|
transport
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0813
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006811
|
ion transport
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0406
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0006813
|
potassium ion transport
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0633
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006685
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006686
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011014
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR011066
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016020
|
membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0472
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0812
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0016021
|
integral to membrane
|
GO_REF:0000023
|
IEA: Inferred from Electronic Annotation
|
SP_SL:SL-9909
|
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0030955
|
potassium ion binding
|
GOA:spkw SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0630
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|

|
GO:0055085
|
transmembrane transport
|
GOA:interpro GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR006685
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.H46aa318da897d&page=20589&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|}


<big>'''Interactions'''</big>

{{Product_interactions_help}}
{| id="T46aa31903870e" class=" tableEdit Product_interactions_table dataTable"
|- {{table heading style}}
!|Partner Type!!Partner!!Notes!!References!!Evidence

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.T46aa31903870e&page=20589&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table] || || || ||
|}


</protect>
===Notes===

==Localization==

{{Product_localization_help}}
{| id="D46a7c2fc89ca0" class=" tableEdit Product_localization_table"
|- {{table heading style}}
!|Compartment!!Description!!Evidence!!Source!!Notes
|-
|
plasma membrane
|
C-terminus localized in the cytoplasm with 12 predicted transmembrane domains
|
Daley et al. (2005) <ref name=PMID:15919996/>
|

|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.D46a7c2fc89ca0&page=20589&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table] || || || ||
|}


<protect></protect>

===Notes===

==Structure and Physical Properties==
{{BacktoTop}}
<protect>
<big>'''Physical Properties'''</big>

{{Product_physical_properties_help}}
{| id="W46aa3191eb337" class=" tableEdit Product_phys_prop_table"

|-
!align=left {{table heading style}} |Sequence
||
[http://biocyc.org/ECOLI/sequence-aa?object=G6255-MONOMER at EcoCyc]
<pre>MTMFQYYKRS RHFVFSAFIA FVFVLLCQNT AFARASSNGD LPTKADLQAQ LDSLNKQKDL
SAQDKLVQQD LTDTLATLDK IDRIKEETVQ LRQKVAEAPE KMRQATAALT ALSDVDNDEE
TRKILSTLSL RQLETRVAQA LDDLQNAQND LASYNSQLVS LQTQPERVQN AMYNASQQLQ
QIRSRLDGTD VGETALRPSQ KVLMQAQQAL LNAEIDQQRK SLEGNTVLQD TLQKQRDYVT
ANSARLEHQL QLLQEAVNSK RLTLTEKTAQ EAVSPDEAAR IQANPLVKQE LEINQQLSQR
LITATENGNQ LMQQNIKVKN WLERALQSER NIKEQIAVLK GSLLLSRILY QQQQTLPSAD
ELENMTNRIA DLRLEQFEVN QQRDALFQSD AFVNKLEEGH TNEVNSEVHD ALLQVVDMRR
ELLDQLNKQL GNQLMMAINL QINQQQLMSV SKNLKSILTQ QIFWVNSNRP MDWDWIKAFP
QSLKDEFKSM KITVNWQKAW PAVFIAFLAG LPLLLIAGLI HWRLGWLKAY QQKLASAVGS
LRNDSQLNTP KAILIDLIRA LPVCLIILAV GLILLTMQLN ISELLWSFSK KLAIFWLVFG
LCWKVLEKNG VAVRHFGMPE QQTSHWRRQI VRISLALLPI HFWSVVAELS PLHLMDDVLG
QAMIFFNLLL IAFLVWPMCR ESWRDKESHT MRLVTITVLS IIPIALMVLT ATGYFYTTLR
LAGRWIETVY LVIIWNLLYQ TVLRGLSVAA RRIAWRRALA RRQNLVKEGA EGAEPPEEPT
IALEQVNQQT LRITMLLMFA LFGVMFWAIW SDLITVFSYL DSITLWHYNG TEAGAAVVKN
VTMGSLLFAI IASMVAWALI RNLPGLLEVL VLSRLNMRQG ASYAITTILN YIIIAVGAMT
VFGSLGVSWD KLQWLAAALS VGLGFGLQEI FGNFVSGLII LFERPVRIGD TVTIGSFSGT
VSKIRIRATT ITDFDRKEVI IPNKAFVTER LINWSLTDTT TRLVIRLGVA YGSDLEKVRK
VLLKAATEHP RVMHEPMPEV FFTAFGASTL DHELRLYVRE LRDRSRTVDE LNRTIDQLCR
ENDINIAFNQ LEVHLHNEKG DEVTEVKRDY KGDDPTPAVG</pre>
|-
!align=left {{table heading style}} |Length
||
1,120
|-
!align=left {{table heading style}} |Mol. Wt
||
127.218 kDa
|-
!align=left {{table heading style}} |pI
||
8.2 (calculated)
|-
!align=left {{table heading style}} |Extinction coefficient
||
164,320 - 164,945 (calc based on 18 Y, 25 W, and 5 C residues)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.W46aa3191eb337&page=20589&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table] ||
|}


<big>'''Domains/Motifs/Modification Sites'''</big>
<table>
<tr align="left" valign="top">
<td>


{{Product_domains_motifs_help}}
{| id="C46aa319250b7f" class=" tableEdit Product_motif_table dataTable"
|- {{table heading style}}
!|Type!!Residues!!Description!!Notes!!References
|-
|
motif
|
1-33
|
[[uniprotmanual:signal|UniProt Manual:Signal Peptides]]
|
[http://www.uniprot.org/uniprot/P77338#section_features UniProt:P77338]
|

|-
|
Domain
|
886..1087
|
[http://pfam.janelia.org/family/PF00924 PF00924 Mechanosensitive ion channel]
|

|
PMID:19920124
|-
|
Domain
|

|
Analysis of KefA organization by PhoA fusion
|
transmembrane topology is investigated in Figure 2
|
PMID:11985727

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.C46aa319250b7f&page=20589&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table] || || || ||
|}


</td>
<td>


<motif_map/>
{{TMHMM Picture|kefA}}
</td>
</tr>
</table>

<table><tr valign='top'><td>
<big>'''Structure'''</big> 

{{Product_structure_help}}
{| id="O46a7c2fe24ef6" class=" tableEdit Product_structure_table"

|-
!align=left {{table heading style}} |Structures
||
<beststructure>
gene=kefA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.O46a7c2fe24ef6&page=20589&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table] ||
|}


</td><td></protect>
==== Structure figures ====

<protect>
</td><tr><table></protect>
===Notes===

==Gene Product Resources==
{{BacktoTop}}

{{Product_resources_help}}
{| id="T46aa3192e5ec2" class=" tableEdit Product_resource_table"
|- {{table_heading_style}}
!|Resource type!!Source!!Notes/Reference

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.T46aa3192e5ec2&page=20589&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table] || ||
|}


<protect></protect>
===Notes===

==Accessions in Other Databases==
{{BacktoTop}}

{{Gene_accessions_help}}
{| id="U46aa31933bd0f" class=" tableEdit Gene_accessions_table"
|- {{table_heading_style}}
!|Database!!Accession!!Notes
|-
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G6255-MONOMER EcoCyc:G6255-MONOMER]
|

|-
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P77338 UniProt:P77338]
|

|-
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
|
[http://pfam.janelia.org/protein/P77338 Pfam:P77338]
|

|-
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_414998 RefSeq:NP_414998]
|

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.20589.U46aa31933bd0f&page=20589&pagename={{FULLPAGENAMEE}}&type=0&template=Gene_accessions_table edit table] || ||
|}


<protect></protect>
===Notes===

==Links==
{{BacktoTop}}


{| id="U46a7c3017e488" class=" tableEdit Links_table"
|- {{table_heading_style}}
!|Name!!URL!!Comments

|- class="tableEdit_footer"
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|}


<noinclude>
==References==
{{BacktoTop}}
{{RefHelp}}
<references />
__NOTOC__
===Categories===
{{BacktoTop}}
[[Category:Proteins]]

kefA:Gene

2011-03-28T20:50:07Z

Azweifel: Table edited by Azweifel via TableEdit

abgT:Gene

2011-03-15T19:18:50Z

Azweifel: Table edited by Azweifel via TableEdit

abgA:Gene

2011-03-15T18:58:08Z

Azweifel: Table edited by Azweifel via TableEdit

parC:Gene

2011-03-14T17:06:01Z

Azweifel: Table edited by Azweifel via TableEdit

dnaA:Gene

2011-03-09T18:55:59Z

Azweifel: Table edited by Azweifel via TableEdit

PMID:7007354

2011-03-09T18:53:58Z

Azweifel: Fill PMID: Page!

{{RightTOC}}
<protect>
 '''Schaus, N, O'Day, K, Peters, W and Wright, A''' (1981) Isolation and characterization of amber mutations in gene dnaA of escherichia coli K-12.''J. Bacteriol.'' '''145''':904-13

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>Amber mutants with defects in the dnaA gene of Escherichia coli K-12 were isolated after localized mutagenesis of the tna-dnaA region of the chromosome. We isolated 36 mutants defective in the initiation of deoxyribonucleic acid replication as determined by their dependence upon integrative suppression by a P2 sig5 prophage. Three of the 36 mutants were shown to contain amber mutations through the use of a temperature-sensitive amber suppressor. These mutations, which mapped between gyrB and tna, were characterized genetically and biochemically as amber mutations in dnaA.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7007354 PubMed]

|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{| id="J4d77ccc6698d7" class=" tableEdit GO_table_reference"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177227.J4d77ccc6698d7&page=177227&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
|}
</protect>

==EcoliWiki Links {{HelpIcon|Help:Literature}} ==
{{LitLinks}}

==See also==

==References==
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PMID:7007354

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dnaA:Gene

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dnaA:Gene

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Septation

2011-03-02T16:51:48Z

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==General Description {{HelpIcon|Help:Processes}}==
Invagination of the inner and outer membranes, as well as the cell wall that occurs to separate daughter cells. There are 4 main steps:
*Selection of the division site
*Recruitment of the septal proteins to the division site and formation of the ring
*Constriction of the membrane and cell wall
**Tetart ''et al.'' (1992) determined that cell division is not coupled to termination of replication, but to the segregation of the chromosomes<ref name='PMID:1943703'/>.
**Z ring dynamics were investigate in Addinall ''et al.''(1997)<ref name='PMID:9209044'/>.
**GTP-dependent activation stage and hydrolysis stage<ref name='PMID:1528268 '/><ref name='PMID:1528267'/>
*Separation of the 2 daughter cells

==Components {{HelpIcon|Help:Processes}}==
FtsZ(Z ring)<ref name='PMID:2045370'/>, FtsA, FtsK<ref name='PMID:9495771'/><ref name='PMID:9723913'/>, FtsN<ref name='PMID:9282742'/>, FtsI, FtsE, FtsX, FtsQ<ref name='PMID:9882666'/>, etc.
*Absolutely all septation events include FtsZ<ref name='PMID:8432706'/>.

In order to ensure the chromosome doesn't get guillotined, TopoIV and the XerCD recombinase are also localized to the septa, via FtsK, but they are not involved directly in the membrane closure.

[[Image:Geissler 2005 1.jpg]]
<ref name='PMID:16194242'/>

Some of the experiments that helped to order the components of this recruitment pathway can be found in Chen ''et al.'' (1999)<ref name='PMID:11703663'/>, Weiss ''et al.'' (1999)<ref name='PMID:9882665'/>, Ghigo ''et al.'' (1999)<ref name='PMID:10027987'/>, Wang and Lutkenhaus (1998)<ref name='PMID:9723913'/>, and Mercer and Weiss (2002)<ref name='PMID:11807049'/>.

FtsI info<ref name='PMID:9614966'/>

==Function {{HelpIcon|Help:Processes}}==

==Regulation {{HelpIcon|Help:Processes}}==
Z ring formation can be inhibited by SulA (via recA-dependent SOS response) or by the action of the Min system<ref name='PMID:17085577'/><ref name='PMID:8432706'/>.
SOS gets triggered in response to DNA damage. ''sulA'' is one of many genes whose expression gets upregulated upon LexA repressor cleavage<ref name='PMID:9068638'/>. The SulA protein directly binds to monomeric FtsZ and inhibits its polymerization<ref name='PMID:12808143'/>.

The FtsK protein couples septation and chromosome segregation, however only the N-terminal domain of FtsK functions in cell division<ref name='PMID:9721304'/>.

==Cell Biology {{HelpIcon|Help:Processes}}==
Mutations can occur which cause cells to grow as septated chains instead of filaments. Some of these mutations are:
*[[xerC:Gene|''xerC'']]
*[[ftsK:Gene|''ftsK'']] (its CTD must be present at the septum for correct functioning of Xer at ''dif'' <ref name='PMID:11114887'/>, mutations that suppress the ''ftsK44'' chaining phenotype are described in Geissler and Margolin (2005)<ref name='PMID:16194242'/>.
*[[amiC:Gene|''amiC'']]

==Experimental Resources {{HelpIcon|Help:Processes}}==
''ftsK'' deletions and septal ring component plasmids are listed in Geissler and Margolin (2005)<ref name='PMID:1614242'/>.

==Comparison with other organisms {{HelpIcon|Help:Processes}}==

==Notes {{HelpIcon|Help:Processes}}==

==References==
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__NOTOC__
<noinclude></noinclude>

[[Category:Processes:{{PAGENAME}}]]
[[Category:Processes]]

ftsZ:Gene

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PMID:8016071

2011-02-28T18:18:17Z

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{{RightTOC}}
<protect>
 '''Bramhill, D and Thompson, CM''' (1994) GTP-dependent polymerization of Escherichia coli FtsZ protein to form tubules.''Proc. Natl. Acad. Sci. U.S.A.'' '''91''':5813-7

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>The FtsZ protein is a GTPase that is essential for cell division in Escherichia coli. During cytokinesis, FtsZ localizes to a ring at the leading edge of septum synthesis. We report the GTP-dependent polymerization of purified FtsZ measured by sedimentation and light scattering. Electron microscopy of polymerized FtsZ revealed structures including tubules 14-20 nm in diameter with longitudinal arrays of protofilaments. FtsZ depolymerized upon removal of GTP and repolymerized after subsequent GTP addition. Mutant FtsZ84 protein polymerized inefficiently, suggesting that polymerization is important for the cellular role of FtsZ in division. The possibility that tubules of FtsZ protein form a cytoskeleton involved in septum synthesis is consistent with our data.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8016071 PubMed]

|}
</protect>
==Significance {{HelpIcon|Help:Literature}} ==
{{LitSignificance}}

== Useful Materials and Methods {{HelpIcon|Help:Literature}}==
{{LitMaterials}}

==Annotations {{HelpIcon|Help:Literature}}==
<protect>

{| id="H4d6be6e9c2726" class=" tableEdit GO_table_reference"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177206.H4d6be6e9c2726&page=177206&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
|}
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<references/>

PMID:8016071

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{{RightTOC}}
<protect>
 '''Addinall, SG, Bi, E and Lutkenhaus, J''' (1996) FtsZ ring formation in fts mutants.''J. Bacteriol.'' '''178''':3877-84

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>The formation of FtsZ rings (Z rings) in various fts mutants was examined by immunoelectron microscopy and immunofluorescence. In two temperature-sensitive ftsZ mutants which form filaments with smooth morphology, the Z ring was unable to form. In ftsA, ftsI, and ftsQ mutants, which form filaments with an indented morphology, Z rings formed but their contraction was blocked. These results indicate that fully functional ftsA, ftsQ, and ftsI genes are not required for Z-ring formation and are unlikely to have a role in localization of the Z ring. The results also suggest that one function of the Z ring is to localize the activity of other fts gene products.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8682793 PubMed]

|}
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{{LitMaterials}}

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<protect>

{| id="U4d6be6ca73a39" class=" tableEdit GO_table_reference"
|- {{table heading style}}
!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177205.U4d6be6ca73a39&page=177205&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
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PMID:8682793

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2011-02-24T16:47:30Z

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{{RightTOC}}
<protect>
 '''Walker, JR, Kovarik, A, Allen, JS and Gustafson, RA''' (1975) Regulation of bacterial cell division: temperature-sensitive mutants of Escherichia coli that are defective in septum formation.''J. Bacteriol.'' '''123''':693-703

{|{{Prettytable}} align = 'center' width= '70%'
|-
|{{TableHeadingColor}} |'''Abstract''' || <protect>Mutations ts2158 and ts1882, which confer temperature sensitivity of septum formation, map near leu in the region of min 2.0 to 2.1 on the Escherichia coli chromosome. These mutants stop division abruptly and grow as filaments at 42 C; when returned to 28 C, division resumes after about 30 min to produce short cells. The product of the gene defined by these mutations probably is required during all stages of septum formation rather than specifically for initiation of septation. Filaments that formed at 42 C contained incomplete constrictiions (septa). When actively dividing filaments (i.e., those incubated at 28 C until division resumed) were shifted to 42 C a second time, division again stopped abruptly and incomplete constrictions persisted during the incubation at 42 C. Filaments that were subjected to 28 C incubation for a brief time (10, 20, or 30 min) before being shifted again to 42 C did not resume division as would be expected of a strain defective in initiating septation. Mutations ts 1882 and ts2158 and recessive to the ts+ allele, which is consistent with the interpretation that these mutations cause the loss of a function. They did not complement each other and presumably represent one cistron. Mutants carrying ts1882 and ts2158 mutations were compared with a mutant defective in the ftA allele, also known to map near leu.</protect>
|-
|{{TableHeadingColor}} nowrap |'''Links''' ||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1097423 PubMed]

|}
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{{LitSignificance}}

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<protect>

{| id="Z4d668ba20a009" class=" tableEdit GO_table_reference"
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!|Gene product!!Qualifier!!GO ID!!GO term name!!Evidence Code!!with/from!!Aspect!!Notes!!Status

|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.177200.Z4d668ba20a009&page=177200&pagename={{FULLPAGENAMEE}}&type=0&template=GO_table_reference edit table] || || || || || || || ||
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2011-02-24T16:47:29Z

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lacI:Expression

2010-11-16T19:50:04Z

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