yjjG:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
yjjG |
|---|---|
| Gene Synonym(s) |
ECK4365, b4374, JW4336[1], JW4336 |
| Product Desc. |
Noncanonical pyrimidine nucleotide house-cleaning phosphatase; dUMP phosphatase activity[4] |
| Product Synonyms(s) |
predicted hydrolase [1], B4374 [2][1], YjjG [2][1] , ECK4365, JW4336, b4374 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. (2005, 2006). yjjG mutants are sensitive to 5-fluoropyrimidine derivatives, such as 5-fluoro-2'-deoxyuridine (Titz, 2007). YjjG has a strict metal requirement for catalytic activity. Poorly utilized substrates include UDP, TDP and a variety of nucleotide monophosphates. A yjjG mutation blocks the utilization of thymine to feed a thyA auxotroph since it must first be converted to thymidine and dUMP dephosphorylated by YjjG is needed for that conversion (Weiss, 2006). YjjG is also called nucleoside 5'-monophosphate phosphohydrolase. HAD superfamily.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
