nusG:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
nusG |
|---|---|
| Gene Synonym(s) |
ECK3973, b3982, JW3945[1], JW3945 |
| Product Desc. |
transcription termination factor NusG[2][3] Stabilizes phage lambda protein N-NusA-RNAP antitermination complex[4] |
| Product Synonyms(s) |
transcription termination factor[1], B3982[2][1], NusG[2][1] , ECK3973, JW3945, b3982 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
Binds TrxA (Kumar, 2004).[4]
Binds Rho [5]
Required for Rho-dependent termination in vivo [6] and enhances Rho-dependent termination in vitro [7] [8] [9]
Maintains genomic integrity [10]
Essential in rac+ strains to prevent expression of toxic prophage gene kilR [11]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Li, J et al. (1993) Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription. Genes Dev. 7 161-72 PubMed
- ↑ Sullivan, SL & Gottesman, ME (1992) Requirement for E. coli NusG protein in factor-dependent transcription termination. Cell 68 989-94 PubMed
- ↑ Nehrke, KW & Platt, T (1994) A quaternary transcription termination complex. Reciprocal stabilization by Rho factor and NusG protein. J. Mol. Biol. 243 830-9 PubMed
- ↑ Burns, CM & Richardson, JP (1995) NusG is required to overcome a kinetic limitation to Rho function at an intragenic terminator. Proc. Natl. Acad. Sci. U.S.A. 92 4738-42 PubMed
- ↑ Washburn, RS et al. (1996) The mechanism of early transcription termination by Rho026. J. Mol. Biol. 260 347-58 PubMed
- ↑ Washburn, RS & Gottesman, ME (2011) Transcription termination maintains chromosome integrity. Proc. Natl. Acad. Sci. U.S.A. 108 792-7 PubMed
- ↑ Cardinale, CJ et al. (2008) Termination factor Rho and its cofactors NusA and NusG silence foreign DNA in E. coli. Science 320 935-8 PubMed
