ftsK:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
ftsK |
|---|---|
| Gene Synonym(s) | |
| Product Desc. |
essential cell division protein FtsK [3][4][5]; Component of Xer site-specific recombination system[5][6] DNA translocase at septal ring sorting daughter chromsomes[7][6] Couples cell division and chromosome segregation. [8] Required at an early step in septation. [3] |
| Product Synonyms(s) |
DNA-binding membrane protein required for chromosome resolution and partitioning[1], B0890[4][1], DinH[4][1], FtsK[4][1] , dinH, ECK0881, JW0873, b0890 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype |
ts mutants filament |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
FtsK is required for resolution of chromosome dimers at dif by XerCD. FtsK helps keep the nucleoids properly localized, recognizing opposing replichores by using FtsK orienting polar sequences (KOPS). The N-terminal domain is membrane-anchored, localizes to the division septum and is required for cell division. The C-terminal domain has the non-essential translocase activity, which becomes essential for replicating the asymmetric replichores produced by chromosome inversion (Lesterlin, 2008). LexA regulon. Homologous to B. subtilis SpoIIIE protein. The ftsK gene is essential. The filamentous growth of mutants is suppressed by dacA deletions. ftsK44(ts) can be suppressed by an ftsA R286W mutation or by an ftsQAZ plasmid. Divisome.[7]
References
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- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ Arnau, J et al. (1997) Cloning, expression, and characterization of the Lactococcus lactis pfl gene, encoding pyruvate formate-lyase. J. Bacteriol. 179 5884-91 PubMed
- ↑ 3.0 3.1 Wang, L & Lutkenhaus, J (1998) FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response. Mol. Microbiol. 29 731-40 PubMed
- ↑ 4.0 4.1 4.2 4.3 4.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 5.0 5.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 6.0 6.1 Capiaux, H et al. (2002) A dual role for the FtsK protein in Escherichia coli chromosome segregation. EMBO Rep. 3 532-6 PubMed
- ↑ 7.0 7.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Robertson, S (1992) Putting pen to paper. Aust Crit Care 5 2 PubMed
